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Method for studying mechanism of gynura divaricata influencing inflammatory factors in type-II diabetic mice

A technology of inflammatory factors and Baizicai, which is applied in the field of diabetes research and can solve problems that have not been studied in depth

Inactive Publication Date: 2019-09-27
GUANGXI UNIV OF CHINESE MEDICINE
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Problems solved by technology

Baizicai has the function of protecting the liver, but the mechanism of fresh Baizicai on inflammatory factors in liver tissue has not been studied in depth

Method used

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  • Method for studying mechanism of gynura divaricata influencing inflammatory factors in type-II diabetic mice
  • Method for studying mechanism of gynura divaricata influencing inflammatory factors in type-II diabetic mice
  • Method for studying mechanism of gynura divaricata influencing inflammatory factors in type-II diabetic mice

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Embodiment Construction

[0047] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0048] This specific embodiment adopts following technical scheme: its operating steps are as follows:

[0049] 1. Prepare experimental materials

[0050] 1.1. Experimental drug preparation:

[0051] The experimental drug was collected in Guigang, Guangxi. It is the whole plant of the genus Panax notoginseng in the Compositae family. It was identified by Associate Professor Guo Min from the Department of Medicinal Plants, Guangxi University of Traditional Chi...

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Abstract

The invention discloses a method for studying the mechanism of gynura divaricata influencing inflammatory factors in type-II diabetic mice, and relates to diabetes research. The method comprises the following steps: adaptively feeding 50 mice for one week, then randomly dividing into a blank control group and a model group, and feeding with normal feed and high-fat and high-sugar feed; after feeding for 4 weeks, fasting and but feeding with water for 12h overnight, weighing and marking; and injecting STZ for three days, fasting and but feeding with water for 12h overnight, firstly experimenting in advance by using a glucometer and test paper, then monitoring the tail blood glucose of the mice by using a microglucometer, and determinating, wherein the fasting blood glucose being greater than or equal to 11.1mmol / L is used as a model standard for the type-II diabetes. Type-II diabetes mouse models are replicated through coordination of a high-fat diet and intraperitoneal injection of streptozotocin, and influence on the inflammatory factors in the mice after intervention of the fresh gynura divaricate is evaluated, so that a clearer theory is provided for the treatment of the type-II diabetes by the gynura divaricate and further development of a Guangxi-characteristic Chinese herbal medicine.

Description

technical field [0001] The invention relates to the technical field of diabetes research, in particular to a research method for the mechanism of the influence of Chinese cabbage on inflammatory factors in type II diabetic mice. Background technique [0002] With the improvement of people's living standards and changes in lifestyle, the number of diabetic patients is also increasing rapidly, especially young people who eat too much, lack of exercise, and the trend of diabetes rejuvenation is obvious. According to the press release of Beijing Diabetes Prevention Association in 2015, by 2013 The number of patients in my country accounts for about 1 / 3 of the world's total. Diabetes has become one of the diseases with the highest morbidity and mortality in the world, and its high mortality, disability rate and high cost of treating diabetes and its complications, It has caused a serious social and economic burden to the country and the people. China is a country with a large popu...

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Application Information

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IPC IPC(8): A61K49/00A61K36/28A61P3/10
CPCA61K36/28A61K49/0008A61P3/10
Inventor 韦乃球
Owner GUANGXI UNIV OF CHINESE MEDICINE
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