Application of extract of radix astragali in treating cadmium-induced diabetic nephropathy

A technology of astragalus extract and diabetic nephropathy, applied in the field of pharmacology, can solve the problems of lack of treatment methods, late discovery, difficult reversal of lesions, etc., and achieve a significant protective effect.

Inactive Publication Date: 2018-09-07
SHAANXI UNIV OF SCI & TECH
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  • Abstract
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Problems solved by technology

The early clinical symptoms of DN are hidden, and the disease is found late and the disease is difficult to reverse. At present, there is no e...

Method used

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  • Application of extract of radix astragali in treating cadmium-induced diabetic nephropathy
  • Application of extract of radix astragali in treating cadmium-induced diabetic nephropathy
  • Application of extract of radix astragali in treating cadmium-induced diabetic nephropathy

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Embodiment Construction

[0018] The present invention will be further described below in conjunction with the accompanying drawings and embodiments.

[0019] 1. Animal preparation

[0020] 70 male Kunming mice.

[0021] 2. Animal model construction and group processing

[0022] 1. Grouping

[0023] The mice were randomly divided into 7 groups with 10 mice in each group. They were normal control group (group K), cadmium-induced model group (group M), astragalus protection group I (group H), positive drug control group I (group Y), STZ control group (group S), and astragalus protection group II (H2 group), positive drug control group II (Y2 group), see Table 1.

[0024] 2. Protective drugs

[0025] 1) Preparation of Astragalus extract

[0026] The Radix Astragali is crushed, passed through a 40-mesh sieve, 10g of the medicinal material is taken, pre-soaked in water for 8 hours, and extracted twice with water as a solvent under reflux (about 100°C), and 10 times the amount of the medicinal material...

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Abstract

The invention provides application of an extract of radix astragali in treating cadmium-induced diabetic nephropathy. High-fat and high-sugar feeding is adopted, and by combing with intraperitoneal injection of cadmium chloride for induction, a mouse model of cadmium-induced diabetic nephropathy is constructed. Experimental studies are carried out on the pathogenesis and characteristics of cadmium-induced diabetic nephropathy and the protective effect of radix astragali from the aspects of oxidative stress level, related protein expression level and the like, and a new approach for treatment of diabetic nephropathy caused by long-term cadmium exposure and high-fat and high-sugar diet is provided.

Description

technical field [0001] The invention belongs to the field of pharmacology, and relates to the activity of astragalus and its extracts in treating diabetic nephropathy, in particular to the treatment of diabetic nephropathy caused by long-term cadmium exposure and high-fat and high-sugar diet. Background technique [0002] Diabetes mellitus (DM) is a serious global public health problem, and the prevalence of diabetes is increasing dramatically. The harmfulness of diabetes is mainly manifested in various chronic complications, which is not only the main cause of death and disability of diabetic patients, but also causes a heavy economic burden. [0003] Diabetic nephropathy (diabetic nephropathy, DN) is a systemic microvascular complication of diabetes and one of the main causes of chronic renal failure. Accumulatively, 20% of T2DM patients with a disease course of more than 10 years develop DN. In western countries, DN has become the main cause of end-stage renal disease (E...

Claims

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Application Information

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IPC IPC(8): A61K36/481A61P3/10A61P13/12
CPCA61K36/481A61P3/10A61P13/12
Inventor 龚频石富兄王兰陈福欣田东杜超
Owner SHAANXI UNIV OF SCI & TECH
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