A porous Prussian blue nanoparticle wrapped by aminated silica and its preparation method and application
A technology of silica and nanoparticles, applied in the field of biomedical materials, can solve the problems of body toxicity and other problems, and achieve the effects of reduced toxicity, high release efficiency, excellent magnetic resonance and fluorescence imaging capabilities
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Embodiment 1
[0039] A method for preparing porous Prussian blue nanoparticles wrapped by aminated silicon dioxide, comprising the following steps in sequence:
[0040] 1) Dissolve 155mg of potassium ferricyanide solid in 30mL of hydrochloric acid with a concentration of 0.2mol / L, mix well to obtain a clear solution, then react at 60°C for 15 hours, centrifuge after the reaction, and wash with water and absolute ethanol in sequence , washed three times, and then centrifuged again, and the centrifuged solid was dried at 35°C to obtain Prussian blue nanoparticles;
[0041] 2) Weigh 10 mg of Prussian blue nanoparticles prepared in step 1) and 80 mg of polyvinylpyrrolidone (PVP-K30) and dissolve them in 10 mL of hydrochloric acid with a concentration of 0.5 mol / L. In the reaction kettle, react at 100°C for 6 hours. After the reaction, centrifuge, wash the obtained solid with water and absolute ethanol in turn, wash three times respectively, and then centrifuge again. The centrifuged solid is dr...
Embodiment 2
[0045] A method for preparing porous Prussian blue nanoparticles wrapped by aminated silicon dioxide, comprising the following steps in sequence:
[0046] 1) Dissolve 140 mg of potassium ferricyanide solid in 50 mL of hydrochloric acid with a concentration of 0.2 mol / L, mix well to obtain a clear solution, and then react at 80 ° C for 18 hours. After the reaction, centrifuge and wash the obtained product with water and ethanol in sequence The solids were washed three times, and then centrifuged again, and the centrifuged solids were dried at 40°C to obtain Prussian blue nanoparticles;
[0047] 2) Weigh 20 mg of Prussian blue nanoparticles prepared in step 1) and 60 mg of polyvinylpyrrolidone (PVP-K30) and dissolve them in 10 mL of hydrochloric acid with a concentration of 0.8 mol / L. In the reaction kettle, react at 140°C for 4 hours. After the reaction, centrifuge, wash the obtained solid with water and absolute ethanol in turn, wash three times respectively, and then centrifu...
Embodiment 3
[0050] A method for preparing porous Prussian blue nanoparticles wrapped by aminated silicon dioxide, comprising the following steps in sequence:
[0051] 1) Dissolve 170 mg of potassium ferricyanide solid in 40 mL of hydrochloric acid with a concentration of 0.1 mol / L, mix well to obtain a clear solution, and then react at 80 ° C for 20 hours. After the reaction, centrifuge and wash the obtained product with water and ethanol in sequence The solids were washed three times, and then centrifuged, and the centrifuged solids were dried at 35°C to obtain Prussian blue nanoparticles;
[0052] 2) Weigh 20 mg of Prussian blue nanoparticles prepared in step 1) and 100 mg of polyvinylpyrrolidone (PVP-K30) and dissolve them in 20 mL of hydrochloric acid with a concentration of 1 mol / L, and transfer them to a polytetrafluoroethylene reactor after mechanical stirring for 2 h reaction at 140°C for 4 hours, after the reaction, centrifuge, wash the obtained solid with water and ethanol three...
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