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Method for preparing hydrogel based on chitosan and negatively charged polyelectrolyte and cellular porous material obtained from the hydrogel

A porous material, hydrogel technology, used in gel preparation, prosthesis, bandages, etc., can solve problems such as instability

Active Publication Date: 2021-07-09
UNIV DE LILLE +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, incorporation of large amounts of mineral fillers into crosslinked hydrogels destabilizes them and promotes their decomposition

Method used

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  • Method for preparing hydrogel based on chitosan and negatively charged polyelectrolyte and cellular porous material obtained from the hydrogel
  • Method for preparing hydrogel based on chitosan and negatively charged polyelectrolyte and cellular porous material obtained from the hydrogel
  • Method for preparing hydrogel based on chitosan and negatively charged polyelectrolyte and cellular porous material obtained from the hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0212] Example 1 : 0.04g chitosan (CHT1) (2% w / w ) and 0.05g (2.5% w / w ) cyclodextrin polymer (CDs1) was co-ground in a mortar and mortar for 1 minute. The obtained powder was put into 1.89 g of ultrapure water for suspension, and then vortexed for 15 seconds (the instantaneous pH of the solution was 3.5 and rose to 4.1). A solution of 0.02 g of glacial acetic acid was then added to the suspension (pH dropped to 3.2 during acid addition and then rose again above 5) and vortexed for 20 seconds. A dense gel was obtained after stirring. The resulting hydrogel contained 89% water.

Embodiment 2

[0213] Example 2 : 0.04g (2% w / w ) chitosan (CHT1) and 0.06g (3% w / w ) cyclodextrin polymer (CDs1) was co-ground in a mortar and mortar for 1 minute. The resulting powder was thrown into 1.88 g of ultrapure water, followed by vortex mixing for 15 seconds. Then 0.02 g of glacial acetic acid solution was added to the suspension which was vortex mixed for 20 sec. A dense gel was obtained after stirring. The resulting hydrogel contained 72% water.

Embodiment 3

[0214] Example 3 : 0.04g (2% w / w ) chitosan (CHT1) and 0.20g (10% w / w ) cyclodextrin polymer (CDs1) was co-ground in a mortar and mortar for 1 minute. The resulting powder was suspended in 1.74 g of ultrapure water, followed by vortex mixing for 15 seconds. Then 0.02 g of glacial acetic acid solution was added to the suspension which was vortex mixed for 20 sec. A dense gel was obtained after stirring. The resulting hydrogel contained 60% water.

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Abstract

The present invention relates to a kind of method for preparing hydrogel, and this method comprises the following steps in sequence: step one (i), provide at least one kind of anionic polymer powder (A) and at least one kind containing amine functional group (-NH 2 ) chitosan powder (B); step two (ii), at least dry mixing the powders (A) and (B) in step one to form a powder mixture; step three (iii), the powder obtained in step two The mixture is suspended in an aqueous medium, and the aqueous medium has a pH capable of dissolving the anionic polymer (A) but the insoluble chitosan (B); step four (iv), adding an acid to the suspension obtained in step three, to A hydrogel is formed. Alternatively, step 3 (iii) and step 4 (iv) are replaced with mixing step 5 (v), and the mixing step 5 (v) includes at least powder (A) and (B) obtained from step 2 (ii). Said mixture of is mixed with acidified aqueous medium containing at least one compound (C), and / or at least one phosphate ester of said compound (C), said compound (C) containing at least one hexose unit or hexose Derivative unit.

Description

technical field [0001] The present invention relates to the technical field of methods for preparing hydrogels, in particular implantable hydrogels, and methods for preparing porous materials from said hydrogels, in particular, methods for preparing physical hydrogels technology field. [0002] The invention also relates to the technical field of hydrogels, porous materials obtained from said hydrogels, in particular sponges, and medical devices comprising such hydrogels or porous materials. Background technique [0003] Hydrogels or macrogels, which generally mainly contain water, are polymer matrices that are swelled by a large amount of water. The macromolecules are interconnected to form a network that can constitute a scaffold, making the gel a material with viscoelastic properties. [0004] Bonds between polymer chains can take two forms: permanent or reversible. When it is permanent, the presence of covalent bonds can be observed; these are called chemical hydrogel...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/05C08J3/075
CPCC08J3/05C08J3/075C08J2305/08C08J2305/16C08J2405/08C08J2405/16A61L26/008A61L27/52A61M3/005B01J13/0056B01J13/0069C08J9/0066C08J9/28C08J2205/022
Inventor N·布拉奇曼B·马特C·弗洛雷斯F·卡佐F·柴N·塔巴里M·洛佩·埃雷迪亚
Owner UNIV DE LILLE