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Oral medicament with anti-depression active component

An active ingredient, antidepressant technology, applied in the field of antidepressant drugs, can solve the problems of difficult to determine active ingredients and mechanism of action, complex natural drug ingredients, narrow antidepressant spectrum, etc. Effect

Inactive Publication Date: 2018-04-24
SUZHOU SCI&TECH TOWN HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, synthetic drugs have defects such as narrow antidepressant spectrum, large side effects, high drug price, and easy relapse; natural drugs have problems such as complex ingredients, slow efficacy, and difficulty in determining the active ingredients and mechanism of action.

Method used

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  • Oral medicament with anti-depression active component
  • Oral medicament with anti-depression active component
  • Oral medicament with anti-depression active component

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Preparation of Chinese medicine extract: (1) wash and dry 8 parts by weight of Bupleurum bupleurum, 5 parts by weight of licorice, 5 parts by weight of peony, and 3 parts by weight of jujube for future use; (2) coarsely pulverize the spare Chinese medicine and pass through Sieve, mix evenly in the water extraction tank, add water 8 times the weight of the medicinal materials and decoct for 2 hours, and collect the filtrate; (3) Repeat the decoction 3 times, filter to remove the filter residue, and combine the filtrate after each decoction; (4) ) The combined filtrate was concentrated under reduced pressure to 1 / 15 of the original volume, and stored for later use.

[0019] Preparation of antidepressant active ingredients: 0.1mol of 3,7-dimethyl-2,6-octadienal, 0.22mol of decanol, 2mL of acetic acid and 250mL of ethanol were added to the reaction vessel in sequence, under nitrogen protection Heating under reflux for 4 to 5 hours, obvious stratification appeared in the rea...

Embodiment 2

[0022] In the preparation process of the Chinese medicine extract of Example 1, the dosage of the four kinds of Chinese medicines was adjusted to: 6 parts by weight of Bupleuri, 4 parts by weight of Radix Glycyrrhizae, 4 parts by weight of Peony, and 2 parts by weight of Jujube, and the rest of the preparation process was the same as in Example 1. .

Embodiment 3

[0024] In the preparation process of the antidepressant active ingredient of Example 1, decyl alcohol was replaced with myristyl alcohol, and the rest of the preparation process was the same as in Example 1.

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PUM

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Abstract

The invention relates to an oral medicament with an anti-depression active component. The oral medicament comprises traditional Chinese medicine composition extract liquid and the anti-depression active component. Radix bupleuri, radix glycyrrhizae, paeonia lactiflora and fructus jujubae are matched with one another according to specific weights and then are decocted, and concentration is carriedout to obtain the traditional Chinese medicine composition extract liquid; the anti-depression active component is 3, 7-dimethyl-2, 6-octadiene aldehyde di-alkoxy acetal, and condensation is carried out on 3, 7-dimethyl-2, 6-octadiene aldehyde and fatty alcohol to obtain the 3, 7-dimethyl-2, 6-octadiene aldehyde di-alkoxy acetal. The oral medicament has the advantages that the oral medicament is mild and is few in side effect and little in irritation just like traditional Chinese medicines; the oral medicament can become effective fast just like western medicines, and targeted treatment can becarried out by the aid of the oral medicament just like the western medicines; raw materials for the oral medicament are low in cost, and accordingly the oral medicament is competitive in terms of price.

Description

technical field [0001] The invention relates to the field of antidepressant drugs, in particular to an oral medicament containing novel antidepressant active ingredients. Background technique [0002] Depression is a kind of mood (emotional) disorder. It is mainly manifested as a significant and persistent low mood. Mild cases are characterized by poor mood and lack of interest. Depression is a common mental disease that seriously endangers human physical and mental health. The World Health Organization has listed it as one of the top ten serious diseases. With the rapid development of social economy and the accelerated pace of life, people's pressure increases, various emotional impacts increase, and the incidence of depression increases year by year. Depression has been called "the epidemic of the twenty-first century." [0003] Drugs for the treatment of depression are divided into two categories: synthetic drugs and natural drugs. Synthetic drugs include tricyclic and ...

Claims

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Application Information

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IPC IPC(8): A61K36/725A61K9/08A61K47/46A61P25/24A61K31/08
CPCA61K9/0095A61K31/08A61K36/233A61K36/484A61K36/65A61K36/71A61K36/725A61K47/46A61K2300/00
Inventor 徐燕
Owner SUZHOU SCI&TECH TOWN HOSPITAL