Implant material for promoting bone wound healing and preparation method thereof

Abstract

The invention discloses an implant material for promoting bone wound healing and a preparation method thereof, and relates to the technical field of medical materials. The orthopedic implant material consists of a polylactic acid matrix and a medical magnesium alloy skeleton suspended in the polylactic acid matrix. The medical magnesium alloy The skeleton is composed of multi-layered wavy network structures made of medical magnesium alloy wires. The surface of the polylactic acid matrix is ​​decorated with a porous hydroxyapatite layer, and the micropores of the hydroxyapatite layer are filled with Dan Phenolic acid B microcapsules and vancomycin microcapsules. The orthopedic implant material of the present invention has good biocompatibility, large specific surface area and high porosity, is suitable for the growth of new bone cells, promotes the bridging and healing of broken ends of fractures, and has the stability of fixation force during the bridging and healing of broken ends of fractures Strong, can prevent secondary fractures; in addition, it can maintain the effective concentration of salvianolic acid B and vancomycin in the drug receiving system for a long time, play a role in continuous anti-inflammatory and promote the bridging and healing of fracture ends.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to an implant material for promoting bone wound healing and a preparation method thereof. Background technique [0002] Internal bone fixation is a routine method in orthopedic trauma surgery, bone defect repair surgery, and plastic surgery. Currently, internal fixation plates and screws are most commonly made of pure titanium or titanium alloy, which have stable fixation effects and superior biocompatibility. It provides a good internal environment for bone tissue healing, but it also has the following problems: (1) The elastic modulus of titanium metal is 8 times that of cortical bone, and it has a stress shielding effect on normal bone tissue, which is easy to cause osteoporosis and relapse Fracture; (2) It cannot be degraded and absorbed. If it is used for a long time, it will block X-rays and affect imaging examinations and chemotherapy for tumor patients. Therefore,...

AI Technical Summary

Problems solved by technology

[0002] Internal bone fixation is a routine method in orthopedic trauma surgery, bone defect repair surgery, and plastic surgery. Currently, internal fixation plates and screws are most commonly made of pure titanium or titanium alloy, which have stable fixation effects and superior biocompatibility. It provides a good internal environment for bone tissue healing, but it also has the following problems: (1) The elastic modulus of titanium metal is 8 times that of cortical bone, and it has a stress shielding effect on normal bone tissue, which is easy to cause osteoporosis and relapse Fracture; (2) It cannot be degraded and absorbed. If it is used for a long time, it will block X-rays and affect imaging examinations and chemotherapy for cancer patients.

However, the mechanical strength of the absorbable internal fixation polymer material is insufficient. If the absorbable polymer plate is fixed on the broken end of the fracture under a large force, as the absorbable plate degrades, the fixation force will weaken, which may lead to secondary fractures.