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Application of rifamycin-nitroimidazole coupling molecule

A technology of nitroimidazolium and rifamycin, applied in the field of medicine, can solve the problems of low efficacy, side effects, serious drug resistance and the like

Active Publication Date: 2018-05-18
TENNOR THERAPEUTICS (SUZHOU) LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the variety of mycobacteria causing NTM infection, with different growth rates and characteristics, and different sensitivities to antimicrobial agents, long-term antimicrobial treatment is often required, with low success rate and significant side effects
To make matters worse, NTMs are becoming more resistant and less effective to existing treatments

Method used

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  • Application of rifamycin-nitroimidazole coupling molecule
  • Application of rifamycin-nitroimidazole coupling molecule
  • Application of rifamycin-nitroimidazole coupling molecule

Examples

Experimental program
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Embodiment 1

[0018] This example provides the application of a rifamycin-nitroimidazole conjugate molecule in anti-NTM, the rifamycin-nitroimidazole conjugate molecule has the structure shown in formula I:

[0019]

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PUM

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Abstract

The invention provides application of a rifamycin-nitroimidazole coupling molecule, or a stereoisomer, an aquo-complex, a deuterated material, an ester, a solvate, a crystal form, a metabolite, pharmaceutically acceptable salt or prodrug thereof in resisting non-mycobacterium tuberculosis, the rifamycin-nitroimidazole coupling molecule has a structure shown in Formula I. The rifamycin nitroimidazole coupling molecule, or the stereoisomer, the aquo-complex, the deuterated material, the ester, the solvate, the crystal form, the metabolite, the pharmaceutically acceptable salt or the prodrug thereof can effectively resist non-mycobacterium tuberculosis and can be used for treating infections caused by non-mycobacterium tuberculosis.

Description

technical field [0001] The invention relates to the application of a rifamycin-nitroimidazole coupling molecule, which belongs to the technical field of medicine. Background technique [0002] Non-tuberculous mycobacteria (NTM), also known as atypical mycobacteria, refers to bacteria other than mycobacterium tuberculosis complex (MTC) and Mycobacterium leprae (Mycobacterium leprae). of mycobacteria. There are many ways to classify mycobacteria. From the perspective of clinical guidance, NTM can be simply divided into rapidly growing mycobacteria (RGM) and slowly growing mycobacteria (SGM). Medication choices provide useful information. Given the popularity of solid cultures, this sorting method can be implemented without special techniques and additional manipulations, making it practical. RGM can obtain macroscopic colonies within 3-7 days on solid medium, while SGM needs several weeks. The most common clinically valuable RGMs include Mycobacterium abscessus, Mycobacter...

Claims

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Application Information

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IPC IPC(8): C07D498/22A61K31/438A61K47/54A61P31/04
CPCC07D498/22
Inventor 马振坤袁鹰刘宇王晓梅
Owner TENNOR THERAPEUTICS (SUZHOU) LTD
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