Application of rifamycin-nitroimidazole coupling molecule

Abstract

The invention provides application of a rifamycin-nitroimidazole coupling molecule, or a stereoisomer, an aquo-complex, a deuterated material, an ester, a solvate, a crystal form, a metabolite, pharmaceutically acceptable salt or prodrug thereof in resisting non-mycobacterium tuberculosis, the rifamycin-nitroimidazole coupling molecule has a structure shown in Formula I. The rifamycin nitroimidazole coupling molecule, or the stereoisomer, the aquo-complex, the deuterated material, the ester, the solvate, the crystal form, the metabolite, the pharmaceutically acceptable salt or the prodrug thereof can effectively resist non-mycobacterium tuberculosis and can be used for treating infections caused by non-mycobacterium tuberculosis.

Description

technical field [0001] The invention relates to the application of a rifamycin-nitroimidazole coupling molecule, which belongs to the technical field of medicine. Background technique [0002] Non-tuberculous mycobacteria (NTM), also known as atypical mycobacteria, refers to bacteria other than mycobacterium tuberculosis complex (MTC) and Mycobacterium leprae (Mycobacterium leprae). of mycobacteria. There are many ways to classify mycobacteria. From the perspective of clinical guidance, NTM can be simply divided into rapidly growing mycobacteria (RGM) and slowly growing mycobacteria (SGM). Medication choices provide useful information. Given the popularity of solid cultures, this sorting method can be implemented without special techniques and additional manipulations, making it practical. RGM can obtain macroscopic colonies within 3-7 days on solid medium, while SGM needs several weeks. The most common clinically valuable RGMs include Mycobacterium abscessus, Mycobacter...

AI Technical Summary

Problems solved by technology

Due to the variety of mycobacteria causing NTM infection, with different growth rates and characteristics, and different sensitivities to antimicrobial agents, long-term antimicrob

Images