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Detection kit for detecting related genetic group of CML

A detection kit and the technology of the kit, which are applied in the field of molecular biology, can solve the problems such as the limitation of the diagnosis method of chronic myeloid leukemia and the lack of diagnosis of chronic myeloid leukemia, and achieve the effect of high detection rate and high detection efficiency.

Inactive Publication Date: 2018-05-18
天津见康华美医学诊断技术有限公司
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Problems solved by technology

[0004] The present invention aims at the technical defects of the prior art, and provides a detection kit for detecting CML-related gene groups, so as to solve the limitations of the diagnostic methods of chronic myeloid leukemia in the prior art, and the lack of diagnosis of chronic myelogenous leukemia from the perspective of molecular biology. Myeloid Leukemia Evidence
[0005] Another technical problem to be solved by the present invention is that the diagnostic methods for chronic myelogenous leukemia in the prior art are relatively limited.

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  • Detection kit for detecting related genetic group of CML
  • Detection kit for detecting related genetic group of CML
  • Detection kit for detecting related genetic group of CML

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[0031] Specific embodiments of the present invention will be described in detail below. In order to avoid too many unnecessary details, well-known structures or functions will not be described in detail in the following embodiments. Unless defined otherwise, technical and scientific terms used in the following examples have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.

[0032] Materials and methods:

[0033] Among the patients diagnosed from August 2015 to April 2017 at the Hematology Hospital of Chinese Academy of Medical Sciences and Union Medical Diagnostic Center, according to the following criteria, we conducted continuous enrollment (40 patients).

[0034] The inclusion criteria were: patients diagnosed with chronic myelogenous leukemia (CML) by cytomorphology and flow cytometry.

[0035] The diagnostic results of the 40 patients are shown in Table 3:

[0036] Table 3 List of patient diagnosis results

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Abstract

The invention discloses a sequencing kit for screening mutation of related genes of CML and a following medical explanation database. A related genetic group of CML comprises nine genes such as ASXL1and ABL1. The sequencing kit comprises multiple PCR primers which amplify all exons of the nine related genes of CML. The kit for screening mutation of the genes of CML has the advantages of being high in detection efficiency, wide in coverage of mutant genes, high in detection rate and the like; a given medical explanation report has the advantages of being accurate and authoritative.

Description

technical field [0001] The invention relates to the technical field of molecular biology, and further relates to a detection kit for screening chronic myeloid leukemia-related gene mutations and a medical interpretation database thereof, in particular to a detection kit for detecting CML-related gene groups. Background technique [0002] CML (chronic myeloid leukemia) is a malignant tumor formed by the clonal proliferation of bone marrow hematopoietic stem cells, accounting for 15% of adult leukemia, with a global annual incidence of 1.6-2 / 100,000. It is characterized clinically by anemia, extreme neutrophilia with immature granulocytes, and basophilia, often accompanied by thrombocytosis and splenomegaly. More than 95% of patients will have a reciprocal translocation of chromosome 9 and chromosome 22, resulting in a shortened chromosome 22, known as the Philadelphia chromosome. [0003] The current detection methods of CML mainly involve cell morphology, flow cytometry, cy...

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Application Information

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IPC IPC(8): C12Q1/6886
CPCC12Q1/6886C12Q2600/156
Inventor 汝昆蔺亚妮贾玉娇
Owner 天津见康华美医学诊断技术有限公司
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