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A kind of gastric floating tablet of total alkaloids of Corydalis

A technology of total alkaloids and gastric floating tablets, which is used in drug combination, drug delivery, plant raw materials, etc., can solve the problems of short residence time and frequent dosing, and achieve short floating time, avoid local irritation, and good slowness. release effect

Active Publication Date: 2020-11-03
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned patent uses Corydalis Corydalis to treat stomach pain, and adopts the constant-release preparation technology, which has a short residence time in the stomach and requires frequent administration to maintain the drug effect

Method used

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  • A kind of gastric floating tablet of total alkaloids of Corydalis
  • A kind of gastric floating tablet of total alkaloids of Corydalis

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preparation example Construction

[0057] A preparation method for extracting total alkaloids of Corydalis Corydalis, comprising the following steps:

[0058] (1) The extraction method is as follows: take 8-12 times the mass of Corydalis decoction pieces and ethanol with a concentration of 55-65 wt%, and reflux extraction for 1-3 times, each time for 1.5-2.5 hours. Take the extract.

[0059] (2) Concentrate the extract under reduced pressure (50-60°C, 50RPM) until there is no alcohol smell, centrifuge (5000-10000rpm at 3-5°C for 25-35min), and take the supernatant to make a concentration of 0.3-0.6g Crude drug / mL of sample solution.

[0060] (3) Wet-pack the pretreated macroporous resin into a column with a diameter-to-height ratio of 1:5 to 1:9, and add the sample solution (the sample volume is 1.5 to 2.3BV, and the sample speed is 1.5 to 2.5BV / h), standing still for 1-2 hours, removing impurities with an impurity removal solvent, and discarding the impurity removal solution.

[0061] The impurity removal ...

Embodiment 1

[0066] A gastric floating tablet of total alkaloids of Corydalis, prepared by the following steps:

[0067] (1) Preparation of total alkaloid extract of Corydalis Corydalis: take 8 times the mass of Corydalis Corydalis decoction pieces and ethanol with a concentration of 60 wt%, and reflux extraction for 3 times, 2 hours each time. Take the extract. Concentrate the extract under reduced pressure (60°C, 50RPM) until there is no alcohol smell, centrifuge (7000rpm at 4°C for 30min), and take the supernatant to make a sample solution with a concentration of 0.6g crude drug / mL. The macroporous resin was wet-packed with a diameter-to-height ratio of 1:6, and the sample solution was added (the sample volume was 2BV, and the sample speed was 2BV / h), and it was left to stand for 2 hours, and the impurity removal solvent was used to remove impurities, discarded and removed. Miscellaneous fluid. Among them, the pretreatment method of the macroporous adsorption resin is: soak the macrop...

Embodiment 2

[0071] (1) Preparation of total alkaloid extract of Yanhusuo: Weigh 50 g of Yanhusuo decoction pieces, add 10 times the amount of 55% ethanol, and reflux extraction once, 2.5 hours each time. Combine the obtained extracts, concentrate under reduced pressure at 50°C until there is no alcohol smell, centrifuge (5000rpm at 3°C ​​for 35min), and take the supernatant to make a concentration of 0.3g crude drug / mL sample solution. Weigh the processed D141 resin (diameter-to-height ratio 1:5) and put it on the column by wet method, load 1.5BV Corydalis Corydalis extract at 1.5BV / h, let it stand for 1h, and use 1.5BV 10% ethanol solution as the impurity removal solvent, The speed of impurity removal is 2BV / h, with 5.5BV 88% ethanol as the eluting solvent, and the speed of 2BV / h is used for elution. Concentrate under reduced pressure at ℃ to a thick extract, then dry under normal pressure at 55 ℃, and finally dry in vacuum at 55 ℃ to obtain that.

[0072] (2) Preparation of gastric flo...

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Abstract

The invention relates to the field of traditional Chinese medicine preparations, and discloses rhizoma corydalis total alksloid gastric floating tablets. The rhizoma corydalis total alksloid gastric floating tablets are prepared from an active component and pharmaceutic adjuvants, wherein the active component is a rhizoma corydalis total alksloid extract, and the pharmaceutic adjuvants are prepared from a sustained-release framework material, a retarding agent, a floating promoter and a flow promoter; the weight ratio of the active component to the pharmaceutic adjuvants is equal to (1 to 1.1)-(1 to 2.1). The rhizoma corydalis total alksloid gastric floating tablets are short in time consumed by floating up and long in floating duration time, and has a slow-release effect; after being taken, the gastric floating tablets are not affected by gastric emptying in virtue of the floating property and the adhesion of forming gel in water, and can stay in the stomach for a long time; the rhizoma corydalis total alksloid gastric floating tablets are high in bioavailability, strong in drug action and low in local irritation, so that the compliance of a patient is greatly improved.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to a gastric floating tablet of total alkaloids of Corydalis Corydalis. Background technique [0002] Corydalis yanhusuo (Corydalis yanhusuo W.T.Wang), a traditional Chinese medicine, is the dried tuber of Corydalis yanhusuo W.T.Wang. famous analgesic. Li Shizhen described Corydalis Corydalis in "Compendium of Materia Medica": "It is specially used to treat all kinds of pains in the whole body, and it is wonderful when used. It is the first medicine for promoting blood circulation and transforming Qi." It can be seen that Corydalis analgesia has a long history and good application prospects. [0003] Due to the good analgesic effect of Corydalis Corydalis, there are many Corydalis Corydalis preparations on the market, such as Yuanhu Zhitong Tablets, Yuanhu Zhitong Capsules, Yuanhu Zhitong Granules, Yuanhu Zhitong Dispersible Tablets, Yuanhu Zhitong Dropping...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/22A61K36/66A61K47/38A61K47/36A61P29/00A61P1/00A61K125/00
CPCA61K9/0065A61K9/205A61K9/2054A61K36/66
Inventor 吴瑾瑾石森林王群星胡锦祥吴素香赵永钦
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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