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A kind of preparation method and application of analgesic bioactive glass powder

A technology of bioactive glass and powder, which is applied in the direction of powder delivery, inorganic active ingredients, non-central analgesics, etc. It can solve the problems of difficult long-term attachment of active ingredients, slow onset of action, and difficulty in immediate relief of gingivitis pain. Achieve the effect of inhibiting the growth of bacteria, good surface viscosity, and long-term anti-sensitivity of teeth

Active Publication Date: 2021-01-26
DONGGUAN HONGYUAN MEDICINE TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the existing oral preparations, the active ingredient is difficult to attach to the lesion, the onset speed is slow, and the pertinence is poor, which makes it difficult for gingivitis patients to relieve pain immediately; and the medication site is in the oral cavity, and the patient is easy to swallow the preparation together with saliva. The poor taste of the medicine makes the patients feel bad when using the medicine, and they are unwilling to accept long-term use, making it difficult to achieve the required course of treatment and curative effect; at the same time, it is difficult for the active ingredients to adhere to the lesion for a long time, so that the patients need to frequently supplement the medicine , It also makes it difficult for patients to adhere to the use of drugs, making gingivitis repeated and difficult to completely heal

Method used

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  • A kind of preparation method and application of analgesic bioactive glass powder
  • A kind of preparation method and application of analgesic bioactive glass powder
  • A kind of preparation method and application of analgesic bioactive glass powder

Examples

Experimental program
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Embodiment 1

[0045] A preparation method of analgesic bioactive glass powder provided in this embodiment comprises the following steps:

[0046] (1) the concentrated nitric acid of 6ml 69wt.% is dispersed in 250ml deionized water, stirs, obtains dilute nitric acid;

[0047] (2) Get 125g ethyl orthosilicate and dissolve in dilute nitric acid, stir and hydrolyze for 1.5 hours;

[0048] (3) 10g of triethyl phosphate was dissolved in the solution obtained in step (2), stirred and hydrolyzed for 0.8 hours;

[0049] (4) Get 62.5g calcium nitrate tetrahydrate and be dissolved in the solution gained in step (3), stir and hydrolyze for 15 minutes;

[0050] (5) Get 700g sodium nitrate, be dissolved in the solution gained in step (4), stir and hydrolyze for 30 minutes;

[0051] (6) Place the solution obtained in step (5) at room temperature to age for 20 hours, the solution gradually forms a gel, and continue to age the gel at 60-70°C for 20 hours;

[0052] (7) drying the gel obtained in step (6) at...

Embodiment 2

[0059] A preparation method of analgesic bioactive glass powder provided in this embodiment comprises the following steps:

[0060] (1) disperse the concentrated nitric acid of 8ml 69wt.% in 250ml deionized water, stir, obtain dilute nitric acid;

[0061] (2) Get 160g ethyl orthosilicate and dissolve in dilute nitric acid, stir and hydrolyze for 0.5 hour;

[0062] (3) 14g of triethyl phosphate was dissolved in the solution obtained in step (2), stirred and hydrolyzed for 0.6 hour;

[0063] (4) Get 54g calcium nitrate tetrahydrate and be dissolved in the solution gained in step (3), stir and hydrolyze for 5 minutes;

[0064] (5) Get 300g sodium nitrate and 300g potassium nitrate, be dissolved in the solution gained in step (4), stir and hydrolyze for 20 minutes;

[0065] (5.1) Get 15g citric acid and be dissolved in the solution gained in step (5), stir and hydrolyze for 15 minutes;

[0066] (6) Place the solution obtained in step (5) at room temperature to age for 15 hours,...

Embodiment 3

[0074] This embodiment provides a method for preparing analgesic bioactive glass powder, comprising the following steps:

[0075] (1) the concentrated nitric acid of 10ml 69wt.% is dispersed in 250ml deionized water, stirs, obtains dilute nitric acid;

[0076] (2) Get 195g ethyl orthosilicate and dissolve in dilute nitric acid, stir and hydrolyze for 2 hours;

[0077] (3) 18g of triethyl phosphate was dissolved in the solution obtained in step (2), stirred and hydrolyzed for 0.7 hour;

[0078] (4) Get 105.5g calcium nitrate tetrahydrate and be dissolved in the solution gained in step (3), stir and hydrolyze for 12 minutes;

[0079] (5) Get 500g sodium nitrate and 100g potassium nitrate, be dissolved in the solution gained in step (4), stir and hydrolyze for 5 minutes;

[0080] (6) Place the solution obtained in step (5) at room temperature to age for 24 hours, the solution gradually forms a gel, and continue to age the gel at 60-70°C for 24 hours;

[0081] (7) drying the ge...

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Abstract

The invention discloses a preparation method of analgesic bioactive glass powder, which is prepared by reacting raw materials such as concentrated nitric acid, ethyl orthosilicate, triethyl phosphate, calcium nitrate tetrahydrate, sodium nitrate, potassium nitrate, potassium-containing compound aqueous solution and the like. . The invention also discloses the application of an analgesic bioactive glass powder, which is applied to oral preparations. The analgesic bioactive glass powder prepared by the invention has good effects of resisting tooth sensitivity and relieving tooth pain, and is especially suitable for targeted treatment of bleeding gums and tooth pain. Potassium ions are slowly released after the bioactive glass powder degrades the dentinal tubules, blocking the nerve transmission in the dentinal tubules and immediately reducing tooth pain; while the bioactive glass has long-term anti-sensitivity effects on teeth, the two complement each other and can be effective It can effectively relieve tooth sensitivity and pain, and the effect can be seen after 3 months of continuous use, which can effectively prevent repeated attacks of gingivitis.

Description

technical field [0001] The invention relates to the technical field of bioactive glass preparation, in particular to a preparation method and application of analgesic bioactive glass powder. Background technique [0002] Biomaterials are a class of high-tech materials, mainly used in the diagnosis and repair of human tissues or organs. The first generation of biomaterials has no biological activity, such as medical metals, inert ceramics, etc., which are biologically inert materials; the second generation of biomaterials, such as bioactive ceramics, hydroxyapatite, etc., can provide tissue conduction for newborn tissues The ability, that is, tissue-conducting biomaterials, has biological activity; in the 1990s, the concept of third-generation biomaterials was proposed, which stimulated cell responses at the molecular level, and belonged to tissue-inducing biomaterials. This kind of material is bioactive and degradable, and at the same time, it has gene activation function, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/00A61K9/14A61K47/02A61P1/02A61P29/00A61P31/02A61P37/08
CPCA61K9/143A61K33/00
Inventor 李祥永李雨丝
Owner DONGGUAN HONGYUAN MEDICINE TECH
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