Kit for detecting susceptibility risk sites of ankylosing spondylitis

Abstract

The invention discloses a kit for detecting susceptibility risk sites of ankylosing spondylitis, belonging to the fields of molecular biology and medical science. The kit is used for detecting the following locus genotypes: rs6600247, rs10865331, rs10510607, rs12504282, rs11742270, rs30187, rs10045403, rs10050860, rs639575, rs8006884, rs2297518, rs9901869, rs8070463 and/or rs2836883. The kit has the beneficial effect that the kit is used for detecting the combination of a plurality of specific susceptibility sites of the Chinese Han population, so that the treatment is assisted.

Description

Technical field [0001] The invention relates to a kit for detecting susceptible risk sites of ankylosing spondylitis, belonging to the fields of molecular biology and medicine. Background technique [0002] Ankylosing spondylitis (AS) is the prototype of spondyloarthropathies (SpA). Its main clinical manifestations are inflammatory low back pain and morning stiffness with insidious onset, which can lead to restricted spinal movement in the later period. Peripheral arthritis, tendon end, ligament attachment point inflammation and other manifestations, spinal rigidity or deformity appear in the late stage of the disease, and the quality of life is seriously reduced. The current prevalence of ankylosing spondylitis in Asian population is 0.23%, and the number of patients exceeds 5 million. It is currently believed that genetic factors, intestinal flora, and immune disorders are all involved in the pathogenesis of AS. Among them, one-third of AS patients have a family history, and A...

AI Technical Summary

Problems solved by technology

[0005] However, in the study of AS susceptibility regions in the Chinese Han population, there are the following limitations and problems to be solved: 1) most studies are candidate loci studies with small sample sizes, and the test efficiency is insufficient; 2) most studies do not consider the genes between the northern and southern populations It is also difficult to correct the confounding factors due to the difference in the MAF frequency of the locus; 3) The results of the genome-wide microarray study of the Chinese population in the early stage suggest that the gene distribution frequency of some loci reported in the European population has a large difference in the Chinese population It was found to be associated with AS, suggesting that there may be population heterogeneity in AS susceptibility regions

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