Tandem mass spectrometer

Abstract

Under the control of an analysis control unit (5), a mass analysis unit (2) carries out product ion scan measurement for a target component within a sample under measurement within a time range in which the target component is introduced and carries out scan measurement of an m / z range including the m / z of ions originating from a reference component within the same time zone. A mass correction information calculation unit (42) determines mass correction information from a measured m / z value for the ions originating from the reference component observed in the MS spectrum obtained from the scanmeasurement and a theoretical m / z value for the ions. A mass correction unit (43) uses this mass correction information for m / z correction of each ion peak originating from the target component observed in the MS / MS spectrum obtained in product ion scan measurement carried out during the same cycle as the scan measurement. MS measurement and MS / MS measurement carried out in the same cycle can beregarded as having been carried out at roughly the same time, so mass correction roughly equivalent to that of an internal standard method can be carried out.

Description

technical field [0001] The present invention relates to a method of fragmenting ions having a specific mass-to-charge ratio m / z in a collision chamber by collision-induced dissociation (CID=Collision-Induced Dissociation) or the like, and performing mass spectrometry on the resulting product ions (fragment ions) A tandem mass spectrometer for analysis. Background technique [0002] MS / MS analysis (tandem analysis), which is one of the methods of mass spectrometry, is a method useful for identifying compounds with large molecular weights or analyzing their chemical structures, and has been widely used in various fields in recent years. A triple quadrupole mass spectrometer that sandwiches a collision cell for CID and arranges quadrupole mass filters before and after it is known as a mass spectrometer that performs MS / MS analysis. In addition, compared with the triple quadrupole mass spectrometer, the so-called Q-TOF mass spectrometer is obtained by replacing the subsequent q...

AI Technical Summary

Problems solved by technology

In contrast, in a tandem mass spectrometer that fragments ions as they pass through a collision cell, mass spectrometry cannot simultaneously perform mass spectrometry on product ions derived from the sample to be measured and non-fragmented ions derived from the standard sample.

Patent Document 1 also describes that in a Q-TOF mass spectrometer, mass calibration using an internal standard method like the above-mentioned IT-TOFMS cannot be performed.

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