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Pharmaceutical composition for treating Alzheimer's disease as well as preparation method and application of pharmaceutical composition

A technology of Alzheimer's disease and composition, which is applied in the direction of drug combination, medical preparation containing active ingredients, pharmaceutical formula, etc.

Inactive Publication Date: 2018-06-12
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many literatures and patents on improving Alzheimer's disease, but there are few on the combination of therapeutic drugs for improving Alzheimer's disease and their synergy to improve the bioavailability of ginkgolic acid, curcumin, and dihydroquercetin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A pharmaceutical composition for treating Alzheimer's disease of the present invention is composed of the following raw materials in weight ratio:

[0036] Ginkgolic acid solid dispersion: curcumin solid dispersion: dihydroquercetin solid dispersion = 1:2:5,

[0037] Ginkgolic acid: PVP=1:4, curcumin:PVP=1:4, dihydroquercetin:PVP=1:4.

[0038] According to the above ratio, take ginkgolic acid and PVP, curcumin and PVP, dihydroquercetin and PVP, dissolve them in appropriate amount of ethanol, spray dry them at 80°C respectively, pass through a 40-mesh sieve according to the above ratio, and mix to obtain the finished product.

Embodiment 2

[0040] A pharmaceutical composition for treating Alzheimer's disease of the present invention is composed of the following raw materials in weight ratio:

[0041] Ginkgolic acid solid dispersion: curcumin solid dispersion: dihydroquercetin solid dispersion = 2:2:8,

[0042] Ginkgolic acid: PEG6000=1:5, curcumin: PEG6000=1:5, dihydroquercetin:

[0043] PEG6000=1:5. Take ginkgolic acid and PEG6000, curcumin and PEG6000 according to the above ratio, two

[0044] Hydrogen quercetin and PEG6000 were melted in a water bath at 75°C, and poured into a stainless steel plate while hot.

[0045] Solidified at -70°C, crushed, dried in vacuum, and mixed according to the above ratio to obtain the finished product.

Embodiment 3

[0047] A pharmaceutical composition for treating Alzheimer's disease of the present invention is composed of the following raw materials in weight ratio:

[0048] Ginkgolic acid solid dispersion: curcumin solid dispersion: dihydroquercetin solid dispersion = 1:3:3,

[0049] Ginkgolic acid: PEG6000=1:6, curcumin: PEG6000=1:6, dihydroquercetin: PEG6000=1:6.

[0050] Take ginkgolic acid and PEG6000, curcumin and PEG6000, dihydroquercetin and PEG6000 according to the above proportions, melt them in a water bath at 80°C respectively, pour them into a stainless steel plate while they are hot and solidify at -70°C, grind them and dry them in vacuum, and press The above proportions are sieved and mixed to obtain the finished product.

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PUM

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Abstract

The invention discloses a pharmaceutical composition for treating Alzheimer's disease as well as a preparation method and an application of the pharmaceutical composition. The pharmaceutical composition consists of the following active ingredients: a ginkgolic acid solid dispersion, a curcumin solid dispersion and a dihydroquercetin solid dispersion at the ratio of (1-2) to (1-10) to (1-10). The composition provided by the invention has the advantages and effects that by combining the ginkgolic acid solid dispersion with the dihydroquercetin solid dispersion and the curcumin solid dispersion,an inhibitory effect can be achieved on metabolic enzymes of glucuronidation and sulfonation of intestinal tracts, so that metabolism of combination drugs is inhibited and bioavailability of the drugsis improved.

Description

technical field [0001] The invention relates to a drug composition for treating Alzheimer's disease and its preparation and application, belonging to the fields of medicine and health products. Background technique [0002] Alzheimer's disease (Alzheimer's Disease, AD) is the most common progressive degenerative neuropathy, and it is a degenerative disease of the central nervous system mainly characterized by progressive cognitive impairment and memory impairment. The main pathological features are intracellular neurofibrillary tangles, extracellular amyloid plaque deposition, and selective neuronal loss in specific brain regions. Its main clinical manifestations are memory loss, cognitive impairment and personality changes. With the increasing proportion of the world's elderly population, the incidence of the disease is on the rise. Every 70 seconds around the world, an elderly person is diagnosed with Alzheimer's disease. According to surveys in the United States and No...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/60A61K9/14A61P25/28A61K31/12A61K31/352
Inventor 孙广炜吕国军刘洋张英赵姗
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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