A kind of preparation method of sodium aescinate

A technology of sodium aescinate and aescin, which is applied in the field of preparation of sodium aescinate, can solve the problems of long time consumption, restriction of production efficiency of sodium aescinate, low total yield, etc., and achieve the effect of improving production efficiency
CN108218948BActive Publication Date: 2021-01-15GANSU CHANGEE BIO PHARMA
9 Cites 1 Cited by

Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Patents(China)
Current Assignee / Owner
GANSU CHANGEE BIO PHARMA
Publication Date
2021-01-15

Smart Images

  • Figure 1
    Figure 1
Patent Text Reader

Abstract

Disclosed is a method for preparing sodium aescinate, relating to the technical field of plant extraction. The method comprises: semen aesculi is taken and subjected to alcohol extraction, the resulting extracting solution is subjected to extraction with chloroform, dichloromethane or ethyl acetate under acidic conditions, and the resulting aescine crude product is successively subjected to salifying, decoloring and acetone precipitation to obtain a sodium aescinate crude product: the sodium aescinate crude product is purified by high-performance liquid chromatography, aescine A, B, C and D are collected and combined to obtain an aescine mixture, wherein same is then further desalinized by high-performance liquid chromatography, and the aescine pure product is collected and salified to obtain the sodium aescinate pure product. The semen aesculi is subjected to extraction and primary purification by an organic solvent, the use of the existing long-lasting processes, such as using macroporous adsorption resins, is avoided, and HPLC deep purification and desalinization steps are carried out on this basis, thereby generally achieving the purpose of significantly shortening the purification cycle and improving the total yield of sodium aescinate, and thus improving the production efficiency of sodium aescinate.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to the technical field of plant extraction, in particular to a preparation method of sodium aescinate. Background technique

[0002] Sodium aescinate is a saponin sodium salt extracted from the dried mature seeds of Aesculus aesculus. Modern pharmacological studies have shown that it has good pharmacological activity: it has strong anti-inflammatory and anti-exudation effects; And eliminate the formation of edema or hematoma; antioxidant free radicals and neuroprotective effect. Clinically, it is mainly used to treat swelling caused by trauma or surgery, cerebral edema, and venous reflux disorders. At the same time, it has been found to be effective in many diseases such as pulmonary heart disease, Hunt's syndrome, tumors, anal canal edema, facial neuritis, and type I nephrotic syndrome. Also has very good curative effect.

[0003] Sodium aescinate mainly has 4 components, which are named sodium aescinin A, sodium aescinin B, so...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More