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Brush for preparing rat oral submucous fibrosis experimental model

A technology of oral mucosa and experimental models, applied in the field of biomedicine, can solve the problems of labor and time cost, inconvenient operation, etc.

Active Publication Date: 2018-07-03
THE FIRST HOSPITAL OF HUNAN UNIV OF CHINESE MEDICINE (CLINICAL RES INST OF TRADITIONAL CHINESE MEDICINE)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The main purpose of the present invention is to provide a brush for preparing an experimental model of rat oral submucosal fibrosis, which aims to solve the problem of inconvenient operation and excessive labor and time cost in preparing the experimental model of rat oral submucosal fibrosis. technical problem

Method used

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  • Brush for preparing rat oral submucous fibrosis experimental model
  • Brush for preparing rat oral submucous fibrosis experimental model
  • Brush for preparing rat oral submucous fibrosis experimental model

Examples

Experimental program
Comparison scheme
Effect test

no. 1 example

[0036]Please refer to Figure 1-2 , in the first embodiment of the present invention, the brush 100 that prepares rat oral submucosal fibrosis experimental model comprises:

[0037] A brush handle 1, a liquid storage cavity 2 is formed in the brush handle 1, and betel nut extract is stored in the liquid storage cavity 2;

[0038] A guide rail 3, the guide rail 3 is arranged at one end of the brush handle 1;

[0039] The brush head 4 is slidably connected with the guide rail 3;

[0040] A plurality of first bristles 5, the first bristles 5 are arranged on the brush head 4;

[0041] An infusion tube 6 , one end of the infusion tube 6 communicates with the liquid storage cavity 2 , and the other end of the infusion tube 6 communicates with the first bristles 5 .

[0042] The partition 7, the partition 7 is fixed in the brush handle 1;

[0043] An elastic member 8 elastically connects the brush head 4 and the partition 7;

[0044] A driving rod 9, one end of the driving rod 9...

no. 2 example

[0055] Please refer to Figure 3-4 , based on the brush 100 for preparing the experimental model of rat oral submucosal fibrosis in the first embodiment of the present invention, in the second embodiment, the brush 200 for preparing the experimental model of rat oral submucosal fibrosis also includes a first roller 9c , the first gear 9d, the first connecting shaft 9e, the first rack 9f and the liquid guide plate 9g, the first roller 9c is arranged on the brush handle 1, the first gear 9d is arranged in the liquid storage cavity 2, the first connecting shaft 9e runs through the brush handle 1, and the first gear 9d is rotationally connected to the first roller 9c through the first connecting shaft 9e, the first rack 9f is meshed with the first gear 9d, and the first rack 9f is set toward one end of the pipe assembly 9b. There is liquid guide plate 9g.

[0056] The principle of use of the brush 200 for preparing the rat oral submucosal fibrosis experimental model of the presen...

no. 3 example

[0059] Please refer to Figure 5-7 Based on the brush 200 for preparing the experimental model of rat oral submucosal fibrosis in the second embodiment of the present invention, in the third embodiment, the brush 300 for preparing the experimental model of rat oral submucosal fibrosis also includes a second roller 9h, The second gear 9i, the second connecting shaft 9j and the second rack 9k, the second roller 9h is arranged in the brush handle 1, the second gear 9i is arranged in the infusion tube 6, the second connecting shaft 9j runs through the brush handle 1, and the second The second roller 9h is rotationally connected to the second gear 9i through the second connecting shaft 9j, one end of the second rack 9k abuts against the acceleration lever 9a, and there is a preset distance between the other end of the second rack 9k and the brush handle 1 .

[0060] As a preferred manner of this embodiment, the accelerator lever 9a further includes a push head 91a, and one end of ...

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Abstract

The invention discloses a brush for preparing a rat oral submucous fibrosis experimental model. The brush for preparing a rat oral submucous fibrosis experimental model comprises a brush handle, a guide rail, a brush head, multiple first bristles, a transfusion tube, a clapboard, an elastic member, a driving rod and an accelerating rod, wherein a liquid storage chamber is formed in the brush handle, an areca nut extraction solution is stored in the liquid storage chamber, one end of the transfusion tube is communicated with the liquid storage chamber, the other end of the transfusion tube is communicated with the first bristles, the elastic member elastically connecting the brush head with the clapboard, one end of the driving rod props against the brush head, the other end of the drivingrod extends into the liquid storage chamber, and the accelerating rod is formed by bending and extending from the other end of the driving rod and stretches into the transfusion tube. The brush for preparing a rat oral submucous fibrosis experimental model, provided by the invention, is convenient to operate, and good in simulation effect, and greatly saves the manpower and time cost of experimenters.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a brush for preparing an experimental model of rat oral submucosal fibrosis. Background technique [0002] Studies have shown that the proliferation of oral mucosal fibroblasts and the deposition of a large amount of extracellular matrix such as collagen caused by chewing a lot of betel nuts are one of the important causes of oral submucosal fibrosis (Oral Submucous Fibrosis, OSF). OSF has been defined as a precancerous state by the World Health Organization. Type I collagen (collagen type I) is a kind of collagen (collagen), which is a structural protein and the main component of the extracellular matrix, and its main function is to support and connect tissue cells. Studies have found that the high expression of type I collagen is closely related to the occurrence of many fibrotic diseases, and it has also been found that type I collagen is also highly expressed in various ...

Claims

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Application Information

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IPC IPC(8): A46B11/00
CPCA46B11/001A46B2200/00
Inventor 谭劲陈安吴丹刘寻岳金宝陈明胡淳李志强谢赛飞
Owner THE FIRST HOSPITAL OF HUNAN UNIV OF CHINESE MEDICINE (CLINICAL RES INST OF TRADITIONAL CHINESE MEDICINE)
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