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Marker for estimating prognosis of H7N9 infected patient and preparation method thereof

A marker, patient technology, applied in measurement devices, instruments, scientific instruments, etc., can solve the problem that the accuracy of cytokines/chemokines is not too high

Active Publication Date: 2018-07-03
THE THIRD PEOPLES HOSPITAL OF SHENZHEN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the accuracy of these cytokines / chemokines is not too high

Method used

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  • Marker for estimating prognosis of H7N9 infected patient and preparation method thereof
  • Marker for estimating prognosis of H7N9 infected patient and preparation method thereof
  • Marker for estimating prognosis of H7N9 infected patient and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] This example provides predictions for patients with mild H7N9 infection.

[0060] The specific values ​​of cytokines and chemokines in CXM patients are as follows:

[0061] BLC: 43.29982891;

[0062] IL-8: 374.8406758;

[0063] IGFBP-1: 3668.174722

[0064] MIF: 2590.348589;

[0065] GDNF: 117.5887511;

[0066] HGF: 197.820787

[0067] IGFBP-2: 767.0861848;

[0068] Leptin: 85.75064157;

[0069] ENA78: 622.3289136

[0070] IP-10: 735.2480753;

[0071] TIMP2: 2346.680924;

[0072] THPO: 46.69589393

[0073] IL10: 219.0461933

[0074] Substituting into the formula to calculate Index Fatality=-36.31342606, Index Mild Disease=-26.55984268. Both calculated values ​​are negative, indicating that it is in the third quadrant, indicating that the patient is a mild patient.

Embodiment 2

[0076] This example provides predictions for patients with severe H7N9 infection.

[0077] The specific values ​​of cytokines / chemokines in JAQ patients are as follows:

[0078] BLC:109.3566895;

[0079] IL-8: 517.5662511;

[0080] IGFBP-1: 6363.313142

[0081] MIF: 1805.586734;

[0082] GDNF: 186.0572423;

[0083] HGF: 200.8144183

[0084] IGFBP-2: 858.8813976;

[0085] Leptin: 218.0770413;

[0086] ENA78: 2748.442632

[0087] IP-10: 4201.190097;

[0088] TIMP2: 2800.141778;

[0089] THPO: 124.8308597

[0090] IL10: 344.3113249

[0091] Substituting into the formula to calculate Index Fatality = -78.87999582, Index Mild Disease = 24.95773602. The calculated ordinate is a negative value, and the abscissa is a positive value, indicating that it is in the fourth quadrant, indicating that the patient is a critically ill patient.

Embodiment 3

[0093] This example provides predictions for H7N9 fatal patients.

[0094] The specific values ​​of cytokines / chemokines in ZWZ patients are as follows:

[0095] BLC:179.1424294;

[0096] IL-8: 393.9435415;

[0097] IGFBP-1: 7693.785287

[0098] MIF: 1026.036142;

[0099] GDNF: 89.99572284;

[0100] HGF: 4120.700385

[0101] IGFBP-2: 1063.392857;

[0102] Leptin: 896.1366553;

[0103] ENA78: 132.4465355

[0104] IP-10: 317.9565868;

[0105] TIMP2: 4870.381737;

[0106] THPO: 85.75064157

[0107] IL10: 317.9565868

[0108] Substituting the formula to calculate Index Fatality = 24.28630174, Index Mild Disease = 24.32447997. The calculated abscissa and ordinate are both positive values, indicating that the patient is in the first quadrant, indicating that the patient is a dead patient.

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Abstract

The invention relates to a marker for estimating prognosis of a H7N9 infected patient. The marker comprises at least one of BLC, IL-8, HGF, MIF, IGFBP-1, GDNF, IGFBP2, Leptin, ENA78, IP10, TIMP2 and THPO. The preparation method comprises the following steps: 1) preparing a plasma sample of the H7N9 infected patient; 2) detecting the cell factor and chemotactic factor of plasma on the plasma sampleto obtain cell factor and chemotactic factor data; and 3) comparing the cell factors and the chemotactic factors in the plasma samples of a healthy control group, a mild case group, a severe case group and a dead group, and obtaining the marker by analyzing a testee working characteristic curve. The single factor for prediction is not reported before and is a newly discovered marker, and the marker can predict the prognosis of the H7N9 patient accurately. According to a multi-factor model for prediction, the accuracy of predicting a dead model reaches 100%.

Description

technical field [0001] The invention belongs to the technical field of biological detection, and is particularly a marker for evaluating the prognosis of H7N9 infected patients, and can evaluate the severity of the disease of the H7N9 infected patients. Background technique [0002] Avian influenza virus belongs to Orthomyxoviridae Influenza A virus genus. Avian influenza virus particles are pleomorphic, with a spherical diameter of 80-120nm and a capsule. The genome is segmented single-stranded negative-sense RNA. According to the antigenicity of the outer membrane hemagglutinin (H) and neuraminidase (N) proteins, it can be divided into 17 H subtypes (H1-H17) and 10 N subtypes (N1-N10). [0003] Human infection with H7 subtype avian influenza virus has been reported before, but infection with N9 subtype avian influenza virus has not been reported. In general, infection with H7 subtype avian influenza virus will only cause mild clinical symptoms, such as mild respiratory ...

Claims

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Application Information

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IPC IPC(8): G01N33/569
CPCG01N33/56983
Inventor 刘映霞王珲李力强麻锦敏王新发
Owner THE THIRD PEOPLES HOSPITAL OF SHENZHEN
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