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Application of inhibitor to preparation of medicine and disinfection product for resisting hand-foot-mouth disease

A hand, foot and mouth disease and inhibitor technology, applied in the field of medicine, can solve the problems of no disinfection products for hand, foot and mouth disease, and achieve the effects of preventing virus invasion, overcoming difficulty in water solubility, and high efficiency

Inactive Publication Date: 2018-07-20
TIANJIN INT JOINT ACADEMY OF BIOTECH & MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many disinfectant and antibacterial topical hand sanitizers on the market today, but there are no disinfection products specifically for hand, foot and mouth disease.

Method used

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  • Application of inhibitor to preparation of medicine and disinfection product for resisting hand-foot-mouth disease
  • Application of inhibitor to preparation of medicine and disinfection product for resisting hand-foot-mouth disease
  • Application of inhibitor to preparation of medicine and disinfection product for resisting hand-foot-mouth disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The detection method that compound of the present invention inhibits virus activity:

[0038] Observation of cytopathic changes and fluorescence assays after virus-infected cells were employed. That is, first add different concentrations of inhibitors to a certain titer of virus, and incubate in a 37°C carbon dioxide incubator for 1-1.5 hours, and then use the mixture of inhibitors and viruses to infect cells, and set up without inhibitors at the same time. And the control group without virus, cultured in a carbon dioxide incubator at 37°C for 5 days, observed the cell lesion with the naked eye, and counted the lesioned cells and the non-lesioned cells to directly calculate the inhibitory effect of the inhibitor on the virus infection .

[0039] Fluorescence assay is to construct a virus with eGFP: construct the eGFP gene at the front end of the virus genome, obtain the RNA of the virus by transcription, and transfect the RNA into RD cells to produce a virus with eGFP,...

Embodiment 2

[0073] Embodiment 2: A kind of leave-on gel for preventing and treating hand, foot and mouth disease

[0074] Preparation:

[0075] Add 100μg of sorbitan monolaurate (Span 20) into 100mL of ethanol and mix well, then add 4.25mg of TJAB-1099, stir to make it completely dissolved to make solution A; dissolve sodium hydroxide in 30mL of deionized water to make solution B; Dissolve 1mL of glycerin, 0.1mL of essence and 1mL of A solution in 3535mL of ethanol and mix to make solution C; Take 0.3g of carbomer and add 30mL of deionized water to fully swell; then add 3mL of B solution and stir to fully swell; Then add 30mL of ethanol, fully stir and swell; finally add all the C solution, fully stir and swell; after the swelling is complete, ultrasonically degas to form a clear and transparent no-clean gel product.

[0076] From the preparation method of the leave-in gel in this example, it can be seen that the composition of the leave-in gel in this example is as follows: TJAB-1099: 0...

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Abstract

The invention provides application of an inhibitor prepared from a pyridine imidazolone derivative, salt of the pyridine imidazolone derivative or a composition of the pyridine imidazolone derivativeand the salt to the preparation of a medicine and a disinfection product which are used for resisting hand-foot-mouth disease, and moreover, also provides the medicine and the disinfection product which are prepared from the inhibitor. According to the application, the medicine prepared by using the inhibitor for resisting an EV71 (Enterovirus 71) and a CAV16 (Coxsackievirus 16) as an effective component can be used for effectively preventing the invasion of virus causing the hand-foot-mouth disease; in addition, different types of the disinfection products are also prepared by using the inhibitor as the effective component, and the disinfection products can be used for directly acting on hands, can be used for specifically killing the virus, has the characteristics of being high in efficiency and good in safety, and the like, can be used for effectively preventing and controlling the transmission of the hand-foot-mouth disease, and is also used for overcoming the problem that the inhibitor is low in water solubility.

Description

technical field [0001] The invention relates to the field of medicine, specifically, the application of an inhibitor in the preparation of anti-hand, foot and mouth disease medicine and disinfection products, and the medicine and disinfection products including the inhibitor. Background technique [0002] Hand-foot-mouth disease (HFMD) is a common global infectious disease. my country has always been a high-incidence area of ​​human hand-foot-mouth disease. It has ranked first in my country's legal infectious diseases for three years, and has a clear upward trend. At present, there is no specific antiviral drug for HFMD on the market. [0003] Human enterovirus 71 (EV71 virus) and Coxsackie virus A16 (CAV16 virus) are the main pathogens causing HFMD in my country in recent years. Clinically, the symptoms caused by CAV16 are usually mild, while in the cases of HFMD caused by EV71, there are a few cases of severe central nervous system disease, resulting in a higher mortality...

Claims

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Application Information

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IPC IPC(8): A61K31/4439A61P31/14A61K45/06C07D401/04
CPCA61K31/4439A61K45/06C07D401/04
Inventor 饶子和杨诚马海秋蔡岩汪颖毛永红郭宇王淑艳贺万丽
Owner TIANJIN INT JOINT ACADEMY OF BIOTECH & MEDICINE