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Composite injection for treating or preventing anesthesia hypotension and preparation method of composite injection

A technology for compound injections and injections, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas. It can solve problems such as the use of methoxamine alone, and achieve low adverse reaction rates and high stability. Good, the effect of maintaining heart rate

Inactive Publication Date: 2018-08-03
AFFILIATED RENHE HOSPITAL OF CHINA THREE GORGES UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the problem of using methoxamine alone in the prior art, the present invention provides a safer and more stable compound injection for treating hypotension under anesthesia

Method used

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  • Composite injection for treating or preventing anesthesia hypotension and preparation method of composite injection
  • Composite injection for treating or preventing anesthesia hypotension and preparation method of composite injection

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preparation example Construction

[0036] The present invention also provides a method for preparing the compound injection described in the above technical solution, comprising the following steps:

[0037] (1) dissolving atropine sulfate and methoxamine hydrochloride with part of water to obtain an active solution;

[0038] (2) mixing the active solution with pharmaceutical excipients to obtain a mixed solution;

[0039] (3) The mixed solution is mixed with the remaining water, followed by filter sterilization and high-temperature sterilization in sequence to obtain a compound injection.

[0040]In the present invention, part of water is firstly used to dissolve atropine sulfate and methoxamine hydrochloride to obtain liquid A, wherein said part of water accounts for 1 / 2 to 2 / 3 of the total volume of water. In the present invention, the temperature of the water for dissolving atropine sulfate and methoxamine hydrochloride is 35-40°C, more preferably 37-39°C. The invention adopts warm water (35-40 DEG C) to ...

Embodiment 1

[0046] Mix 0.2 g of atropine sulfate and 2 g of methoxamine hydrochloride with 35° C. and 666 mL of water for injection, stir and dissolve sufficiently to obtain liquid A. Mix 6 g of citric acid, 3 g of sodium citrate, and 3.5 g of sodium chloride with liquid A, stir and dissolve thoroughly to obtain liquid B. Dilute liquid B to 1000mL with water for injection to obtain a mixed liquid, filter it with a 0.22μM sterilizing filter, pack the filtered solution into ampoules and seal it, and sterilize it by circulating steam at 100°C for 30 minutes to obtain treatment or Compound injection for preventing anesthesia hypotension.

Embodiment 2

[0048] Mix 0.5 g of atropine sulfate and 3 g of methoxamine hydrochloride with 35° C. and 666 mL of water for injection, stir and dissolve sufficiently to obtain liquid A. Mix 6 g of citric acid, 3 g of sodium citrate, and 3.5 g of sodium chloride with liquid A, stir and dissolve thoroughly to obtain liquid B. Dilute liquid B to 1000mL with water for injection to obtain a mixed liquid, filter it with a 0.22μM sterilizing filter, pack the filtered solution into ampoules and seal it, and sterilize it by circulating steam at 100°C for 30 minutes to obtain treatment or Compound injection for preventing anesthesia hypotension.

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Abstract

The invention relates to the field of medicines and provides a composite injection for treating or preventing anesthesia hypotension. 1000 mL of the composite injection comprises 0.1-2g of atropine sulfate, 2-5g of methoxamine hydrochloride, 10-15g of medicinal auxiliary materials and the balance of injection water, and the pH value of the composite injection is adjusted to 4.5+ / -0.3. According tothe composite injection provided by the invention, the atropine sulfate and the methoxamine hydrochloride are adopted as active components, the methoxamine hydrochloride and the atropine sulfate arecompounded, and by virtue of the property that an alpha1-adrenergic receptor stimulant can be antagonized by atropine, reflective decreased heart rates caused by methoxamine hydrochloride can be antagonized. After the two components are compounded, a blood pressure boosting effect which is not inferior to that of independently used methoxamine hydrochloride can be achieved, the probability of reflective decreased heart rates can be reduced, and thus the composite injection provided by the invention is relatively safe and effective when being used for treating or preventing anesthesia hypotension.

Description

technical field [0001] The invention relates to the field of medicines, in particular to a compound injection for treating or preventing anesthesia hypotension and a preparation method thereof. Background technique [0002] Anesthesia hypotension refers to the systolic blood pressure of the anesthetized patient is less than 80mmHg or the blood pressure drops more than 30% of the pre-anesthesia blood pressure during anesthesia. In clinical practice, general anesthesia is often used, especially spinal-epidural anesthesia, which is widely used clinically because of its rapid onset and definite effect. However, it is easy to cause hypotension in patients after general anesthesia, which will pose a certain threat to the life safety of patients. Methoxamine, as a powerful α1-receptor agonist, has an effective preventive effect on hypotensive symptoms caused by general anesthesia. [0003] Methoxamine hydrochloride is an adrenergic receptor agonist, which can contract small arter...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/137A61K31/46A61P9/02
CPCA61K9/0019A61K9/08A61K31/137A61K31/46A61K47/12A61P9/02A61K2300/00
Inventor 廖勇汤枝鹏游艳万静枝杨刚邹学军李璐朱春华
Owner AFFILIATED RENHE HOSPITAL OF CHINA THREE GORGES UNIV
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