Preparation method of 3-substituted dimethyl glutarate and dimethyl glutaconate

A technology of glutaric acid diester and glutaric acid diester is applied in the field of preparation of 3-substituted glutaric acid diester and glutaric acid diester, and can solve the problem of high equipment requirements, inconvenient use, use of hydrogen, etc. problems, to achieve the effect of low requirements for preparation conditions, wide market sources and mild reaction
CN108358783AActive Publication Date: 2018-08-03HAISO TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HAISO TECH
Publication Date
2018-08-03

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Abstract

The invention relates to the field of fine chemical engineering, and particularly relates to a preparation method of 3-substituted dimethyl pentodiate and pentene diester. According to the preparationmethod of 3-substituted dimethyl pentodiate and pentene diester, malonic ester and halomethane are used as raw materials, substitution reaction is performed under an alkaline action, then decarboxylation and esterification reaction are performed so as to prepare 3-substituted dimethyl pentodiate or pentene diester, a structural formula of 3-substituted dimethyl pentodiate is as shown in a compound (V), and a structural formula of pentene diester is as shown in a compound (IX). The preparation method of 3-substituted dimethyl pentodiate and pentene diester is mild in reaction conditions, is easy to operate and is safe. The formula is shown in the description.
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Description

technical field

[0001] The invention relates to the field of fine chemical industry, in particular to a preparation method of 3-substituted glutaric acid diester and glutaconic acid diester. Background technique

[0002] 3-substituted glutaric acid diesters and glutaconic acid diesters are important pharmaceutical and chemical intermediates for the preparation of various five-membered ring compounds. German patent (DE1200279) reported the reaction of dichloromethyl methyl ether and vinyl ketone under the catalysis of zinc isobutyrate to prepare 3-methoxyglutaric acid. However, the gaseous material vinyl ketone used in this method is unsafe and the post-treatment is difficult. Yamamoto et al. (Agric.Biol.Chem.1990, 54 (12), 3269-3274) reported that 3-hydroxyglutaric acid methyl ester was used as raw material to prepare 3-methoxyglutaric acid methyl with iodomethane methylation reaction Esters, raw materials and methyl iodide are expensive, and the preparation cost is high. ...

Claims

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