Application of nobiletin in preparation or screening of drugs for treating diabetes and cardiomyopathy

A technology for diabetic cardiomyopathy and tangerine peel, which is applied in the application field of tangerine peel in the preparation or screening of diabetic cardiomyopathy drugs, and achieves the effects of improving diabetic cardiomyopathy, improving cardiac function, and reversing myocardial hypertrophy.

Inactive Publication Date: 2018-08-17
GUANGZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Nobiletin has anti-inflammatory, anti-virus, anti-cancer effects, but ther

Method used

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  • Application of nobiletin in preparation or screening of drugs for treating diabetes and cardiomyopathy
  • Application of nobiletin in preparation or screening of drugs for treating diabetes and cardiomyopathy
  • Application of nobiletin in preparation or screening of drugs for treating diabetes and cardiomyopathy

Examples

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Embodiment 1

[0024] The specific operation method of the animal experiment: C57BL / 6 mice aged 7-8 weeks were intraperitoneally injected with 0.2% STZ45mg / kg / day for 5 consecutive days. Three days after the injection, the blood glucose of the mice was measured, and the mice with a blood glucose concentration higher than 16.7mmol / L were considered to have successfully established diabetes models and were type I diabetic mice. 7-8 weeks old db / db mice were type Ⅱ diabetic mice: they were randomly divided into ① control group (CTL); ② diabetes group (DM); ③ Nobiletin low dose group (DM+Nob L) n=10 (Nobiletin 15 mg / kg intraperitoneal injection) ④ Nobiletin high-dose group (DM+Nob H) n=10 (Nobiletin 30mg / kg intraperitoneal injection); echocardiography was performed every week to check heart function, and before the end of the experiment, the body weight, blood sugar, and weight of mice in each group were measured. heart function. Hearts were collected for detection of myocardial hypertrophy ind...

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Abstract

The invention discloses application of nobiletin in preparation or screening of drugs for treating diabetes and cardiomyopathy. Whole animal level experiments prove that the nobiletin has effect of improving diabetes and cardiomyopathy. The dosage of the nobiletin dependently improves heart functions of patients with the diabetes and cardiomyopathy, and myocardial remodeling such as myocardial hypertrophy and myocardial fibrosis is reversed obviously.

Description

technical field [0001] The invention relates to a new application of nobiletin, in particular to the application of nobiletin in preparing or screening drugs for diabetic cardiomyopathy. Background technique [0002] Nobiletin is derived from Rutaceae Chuanju, which is mainly obtained by alcohol extraction, extraction, chromatography, crystallization and other processes. Nobiletin has the following medicinal effects: anti-cell agglutination, anti-thrombosis, anti-cancer, anti-fungal, anti-inflammatory, anti-allergic, anti-cholinesterase and anti-epilepsy, while nobiletin is also an accelerator of carbohydrate metabolism . [0003] Nobiletin has anti-inflammatory, anti-virus, anti-cancer and other effects, but there is no detailed report on the application of nobiletin in diabetic cardiomyopathy. Contents of the invention [0004] The purpose of the present invention is to overcome the shortcomings of the prior art and provide the application of nobiletin in the preparati...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61K9/08A61P3/10A61P9/00A61P9/08
CPCA61K9/0019A61K9/08A61K31/352A61P3/10A61P9/00A61P9/08
Inventor 吴晓倩梅峥嵘郑德冲刘祖玫朱小艳周友曾莉欢梁振业
Owner GUANGZHOU MEDICAL UNIV
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