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Preparation method and application of 3D printing artificial blood vessel

An artificial blood vessel and 3D printing technology, applied in the field of artificial organs, can solve the problems of inconsistent mechanical properties of natural blood vessels and artificial blood vessels, and low patency rate of artificial blood vessel transplantation.

Inactive Publication Date: 2018-08-28
SUN YAT SEN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the inconsistency of mechanical properties between natural blood vessels and artificial blood vessels, the patency rate of artificial blood vessel grafts is often low

Method used

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  • Preparation method and application of 3D printing artificial blood vessel
  • Preparation method and application of 3D printing artificial blood vessel
  • Preparation method and application of 3D printing artificial blood vessel

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Embodiment Construction

[0023] In order to enable those skilled in the art to better understand the solution of the present invention, the present invention will be further described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0024] Such as Figure 1 to Figure 7 , figure 1 Schematic diagram of the structure of the artificial blood vessel provided by the present invention; figure 2 It is a schematic diagram of the artificial blood vessel printing device of the present invention; Figure 3-7 It is the fiber structure and mechanical performance test curve of the 3D artificial blood vessel provided by the present invention.

[0025] The preparation of artificial blood vessels is mainly completed by a set of printing equipment. figure 2 Print a device schematic for it.

[0026] A printing device for 3D printing artificial blood vessels, comprising a material supply nozzle 2 and a slider 3, the material supply nozzle 2 is driven by the slider 3 to move l...

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Abstract

The invention discloses a preparation method and application of a 3D printing artificial blood vessel. The 3D printing artificial blood vessel is prepared from the following three layers including aninner layer blood contact layer, a middle layer separation layer and an outer layer loose nanometer fiber layer, wherein the blood contact layer is made of degradable water gel; the middle separationlayer is made of high-elasticity nanometer fiber; the loose nanometer fiber layer is made of straight elastic fiber and wave-shaped toughness fiber. The 3D printing artificial blood vessel provided bythe invention has the advantages that the artificial blood vessel can reach the mechanical intensity and biomechanical features (elasticity and toughness) of the natural blood vessels, and can be used as blood vessel transplanting articles to be applied to the treatment on arteriovenous fistulization, atherosclerosis blood vessel diseases and peripheral vessel diseases.

Description

technical field [0001] The invention relates to the technical field of artificial organs, in particular to the preparation of a 3D printed artificial blood vessel and its application in the medical field. Background technique [0002] The core advantage of 3D medical printing technology is that it can use precious and limited autologous stem cells or seed cells mixed with biocompatible biomaterials to achieve accurate, efficient, high-precision "replication" or small batch production of high bionics for patient transplantation sites Tissue or organ is the direction and trend of the development of transplantation medicine and regenerative medicine. [0003] Atherosclerosis is the most common cardiovascular disease, and the surgical treatment for severe patients is mainly surgical angioplasty, artificial blood vessel or natural blood vessel graft. However, these restorative or alternative treatments suffer from various problems. For example, six months after stent implantati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/50A61L27/40A61L27/58A61F2/06B29C64/20B33Y10/00B33Y30/00B33Y80/00
CPCA61F2/06A61F2240/002A61L27/50A61L27/507A61L27/58B33Y10/00B33Y30/00B33Y80/00
Inventor 文学军王冠蕾
Owner SUN YAT SEN UNIV
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