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Application of fresh ginger heart fire-removing decoction in curing diarrhoea caused by clostridium difficile infection

A technology of ginger Xiexin decoction and Clostridium difficile, applied in the field of medicine, can solve the problems of decreased sensitivity to vancomycin and metronidazole, destruction of beneficial intestinal flora, high symptom recurrence rate, and achieves the phenomenon of not easy recurrence, Long onset time, reducing dryness and heat

Active Publication Date: 2018-09-04
INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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  • Application Information

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Problems solved by technology

[0003] The following problems exist in the treatment of vancomycin and metronidazole: ① Destruction of beneficial intestinal flora; ② The sensitivity of some clinical isolates of Clostridium difficile to vancomycin and metronidazole decreases and the drug resistance rate increases; ③ Symptom recurrence rate as high as 15%-35% etc.

Method used

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  • Application of fresh ginger heart fire-removing decoction in curing diarrhoea caused by clostridium difficile infection
  • Application of fresh ginger heart fire-removing decoction in curing diarrhoea caused by clostridium difficile infection
  • Application of fresh ginger heart fire-removing decoction in curing diarrhoea caused by clostridium difficile infection

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experiment example

[0050] 1. Materials

[0051] 1.1 Drugs

[0052] Dosage of vancomycin: 50mg / kg; medium dose of Jiangxiexin Decoction: 16.4g / kg, low dose of Jiangxiexin Decoction: 8.2g / kg, very low dose of Jiangxiexin Decoction: 4.1g / kg.

[0053] (Explanation: The dosage of Shengjiang Xiexin Decoction is based on the quality of the raw medicinal materials, and the low dosage group is equivalent to the equivalent dosage of the human dosage, and the administration method is intragastric administration).

[0054] 1.2 Animals

[0055] 4-5 weeks old C57BL / 6 mice, weighing 18±2g.

[0056] 2. Methods and results

[0057] The prescription of Shengjiang Xiexin Decoction is: Pinellia 9g, dried ginger 3g, coptis 3g, scutellaria baicalensis 9g, ginseng 9g, jujube 9g (broken), roasted licorice 9g, ginger 12g, the preparation method is to wash Pinellia with boiling water several times Afterwards, it is combined with other 7 herbs for decoction, and the medicinal solution is filtered and concentrated to a...

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to application of fresh ginger heart fire-removing decoction in curing diarrhoea caused by clostridium difficile infection. According to the application of the fresh ginger heart fire-removing decoction in curing diarrhoea caused by clostridium difficile infection, based on the existing pharmacological activity ofthe fresh ginger heart fire-removing decoction, through a large number of experiments and in-depth studies, new clinical efficacy of the fresh ginger heart fire-removing decoction is screened, and experimental results show that the fresh ginger heart fire-removing decoction has the application in curing diarrhoea caused by clostridium difficile infection.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of ginger Xiexin Decoction in treating diarrhea caused by Clostridium difficile infection. Background technique [0002] Clostridium difficile (CD) is a Gram-positive anaerobic bacillus that is transmitted among humans through the fecal-oral route. With the widespread use or even abuse of broad-spectrum antimicrobials, the intestinal flora of patients is imbalanced, which is likely to induce Clostridium difficile infection (CDI), and then a series of diseases such as diarrhea and enteritis. Clostridium difficile infection has become a global epidemiological problem (Clincal InfectionDiseases.2007,45(3):302-307.). It is estimated that Clostridium difficile can be found in the stool of about 35% of hospitalized patients, the prevalence of Clostridium difficile infection in long-term hospitalized patients may be as high as 50%, and about 3% of healthy a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K38/14A61P1/00A61P1/04A61P1/12A61P37/02
CPCA61K36/8888A61K36/9068A61K38/14A61P1/00A61P1/04A61P1/12A61P37/02A61K36/258A61K36/484A61K36/539A61K36/718A61K36/725A61K2300/00
Inventor 黄璐琦苏建荣李慧杨洪军马致洁吕治林龙飞
Owner INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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