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Digital microfluidic chip control platform

A technology of digital microfluidics and manipulation platform, applied in fluid controllers, laboratory utensils, laboratory containers, etc., can solve the problems of heavy work tasks, difficult processing, and high costs, achieve complex biochemical reactions, reduce Replacement cost, the effect of precise control

Pending Publication Date: 2018-09-04
DONGGUAN HEC MEDICAL INTELLIGENT DEVICE R&D CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When the number of micro-droplets is large, the task of connecting the micro-electrode and the power supply is extremely heavy; and the traditional micro-electrode and chip processing are integrated, and the material of the chip can only be selected from materials compatible with the micro-electrode processing technology, and the cost is high , difficult to process
[0004] Therefore, there is an urgent need for a digital microfluidic chip control platform to solve the problem of dependence of digital microfluidic chips on microelectrodes in the prior art

Method used

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  • Digital microfluidic chip control platform

Examples

Experimental program
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Embodiment 1

[0042] This embodiment provides a digital microfluidic chip control platform, such as figure 1 As shown, it includes a chip and a magnetic control module, the chip and the magnetic control module are arranged facing each other, the chip is provided with a microchannel for the flow of the micro-droplet 5, the micro-droplet 5 has magnetism, and the magnetic field strength of the magnetic control module is adjustable, so that The movement of the microdroplet 5 can be magnetically controlled.

[0043] According to specific application requirements, magnetic control modules can be installed on the upper and lower sides of the chip to apply a magnetic field to the micro-droplet 5 on both sides of the chip to achieve more precise and complex control of the trajectory and biochemical reactions of the micro-droplet 5 . Preferably, the magnetic control module in this embodiment is arranged directly under the chip.

[0044] By setting the magnetic control module to control the movement...

Embodiment 2

[0065] This embodiment provides a digital microfluidic chip control platform. This embodiment is basically the same as the first embodiment. For the sake of simplicity, only the differences between this embodiment and the first embodiment will be described.

[0066] In this embodiment, the magnet unit 31 of the magnet group 3 is an electromagnetic coil, and the drive unit 41 of the driver 4 is an electrical component. By controlling whether the electrical component is energized or not, the electromagnetic coil is controlled to have magnetism or not, and it can be controlled by controlling the current. The strength realizes the adjustment of the magnetic field strength, thereby changing the magnetic field strength applied to the micro-droplet 5 and controlling the movement of the micro-droplet 5 .

[0067] The manipulation method of this embodiment will be further described below in conjunction with specific examples.

[0068] Figure 9 and Figure 10 It shows a working princ...

Embodiment 3

[0072] This embodiment provides a method for fusion of micro-droplets 5 using Embodiment 1 and Embodiment 2.

[0073] In biochemical reactions, it is often necessary to fuse two reactants and react after applying certain conditions. The digital microfluidic chip control platform provided by the present invention can well realize this function. Fusion, to achieve the purpose of the reaction.

[0074] Specifically, as Figure 14 and Figure 15 as shown, Figure 14 A single magnet unit 31 controls two micro-droplets 5 to move to a specific position. When the two micro-droplets 5 reach this position, they collide and merge, and after merging into a larger micro-droplet 5, as Figure 15 As shown, it is finally located at the center of the magnet unit 31 . As described in Embodiment 1 and Embodiment 2, the micro-droplet 5 can be controlled by a permanent magnet or an electromagnetic coil, or the movement and position of the micro-droplet 5 can be controlled by the magnetic field...

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Abstract

The invention relates to the technical field of microfluidic chips, and discloses a digital microfluidic chip control platform. The digital microfluidic chip control platform comprises a chip and a magnetic control module, wherein the chip rightly faces the magnetic control module; a microchannel for microdroplets to flow is formed in the chip; the microdroplets are magnetic; the magnetic field strength of the magnetic control module is adjustable; the magnetic control module can magnetically control movement of the microdroplets. According to the digital microfluidic chip control platform provided by the invention, the movement of the microdroplets in the microchannel in the chip is controlled through arrangement of the magnetic control module, the magnetic control module is used for replacing a microelectrode, and a magnetic driving way is used for replacing an electric driving way, so that dependence of the digital microfluidic chip on the microelectrode is eliminated and precise control of the movement of the microdroplets is achieved; in addition, through a split design of the chip and the magnetic control module, the replacement cost is reduced.

Description

technical field [0001] The invention relates to the technical field of microfluidic chips, in particular to a digital microfluidic chip control platform. Background technique [0002] Existing digital microfluidic chips generally adopt micro-electrode drive mode. The micro-electrode processing process involves sputtering, photolithography, corrosion and super-thin coating and other processes, which are expensive and complicated to operate; and all micro-electrodes are disposable. , once the chip is damaged or malfunctions, the chip is scrapped and the cost is high. [0003] The main application field of digital microfluidic chips is the formation and manipulation of micro-droplets (5-200 μm in diameter). In order to match the size of micro-droplets and control the movement of a large number of micro-droplets, it is necessary to process a large number of micro-electrodes. And each microelectrode needs to be connected with a power supply through wires. When the number of mic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00
CPCB01L3/50273B01L2400/043
Inventor 顾志鹏焦政刘仁源程四兴李建霖
Owner DONGGUAN HEC MEDICAL INTELLIGENT DEVICE R&D CO LTD
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