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Technology for preparing low molecular sodium hyaluronate

A sodium hyaluronate and preparation technology, which is applied in the field of preparation of low-molecular-weight sodium hyaluronate, can solve the problems of poor product quality, high molecular weight of small-molecular hyaluronic acid, and high corrosion of equipment, so as to meet the requirements of moisture retention, The effect of superior permeability

Active Publication Date: 2018-09-04
SHANDONG FOCUSFREDA BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In order to solve the above problems and overcome the deficiencies of the prior art, the present invention provides a preparation process of low-molecular-weight sodium hyaluronate with low molecular weight, high biological activity and easy extraction and purification, which can effectively solve the problem of small-molecular hyaluronic acid. Large molecular weight, poor product quality, difficult extraction and purification, and high corrosion to equipment

Method used

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  • Technology for preparing low molecular sodium hyaluronate
  • Technology for preparing low molecular sodium hyaluronate
  • Technology for preparing low molecular sodium hyaluronate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] This embodiment utilizes the method of adding hydrogen peroxide into the alcohol solution to provide an oxidative environment, then adding sodium hyaluronate, degrading it under heating conditions, and purifying the material to obtain low-molecular-weight sodium hyaluronate. The production steps are as follows :

[0027] (1) Preparation of high-concentration organic solvents

[0028] Prepare 1000L 75% alcohol solution in a dissolving tank.

[0029] (2) Add oxidizing agent

[0030] Add 0.5 kg of hydrogen peroxide to the above 75% alcohol solution, start stirring to ensure that the liquid is evenly mixed.

[0031] (3) Control of reaction temperature

[0032] Open the steam valve to ensure that the reaction temperature of the tank is 50°C.

[0033] (4) Add sodium hyaluronate powder

[0034] Dispersively add 10 kg of sodium hyaluronate powder to the above-mentioned heated alcohol solution containing hydrogen peroxide, the molecular weight of the sodium hyaluronate is 1...

Embodiment 2

[0040] This embodiment utilizes the method of adding hydrogen peroxide into the alcohol solution to provide an oxidative environment, then adding sodium hyaluronate, degrading it under heating conditions, and purifying the material to obtain low-molecular-weight sodium hyaluronate. The production steps are as follows :

[0041] (1) Prepare high-concentration organic solvents

[0042] Prepare 1000L 85% alcohol solution in a dissolving tank.

[0043] (2) Add oxidizing agent

[0044] Add 1 kg of hydrogen peroxide to the above 85% alcohol solution, start stirring to ensure that the liquid is evenly mixed.

[0045] (3) Control of reaction temperature

[0046] Open the steam valve to ensure that the reaction temperature of the tank is 60°C.

[0047] (4) Add sodium hyaluronate powder

[0048] Dispersively add 50kg of sodium hyaluronate powder to the above-mentioned heated alcohol solution containing hydrogen peroxide, the molecular weight of the sodium hyaluronate is 1.5MDa, and...

Embodiment 3

[0052] This embodiment utilizes the method of adding hydrogen peroxide into the alcohol solution to provide an oxidative environment, then adding sodium hyaluronate, degrading it under heating conditions, and purifying the material to obtain low-molecular-weight sodium hyaluronate. The production steps are as follows :

[0053] (1) Prepare high-concentration organic solvents

[0054] Prepare 1000L 95% alcohol solution in a dissolving tank.

[0055] (2) Add oxidizing agent

[0056] Add 2 kg of hydrogen peroxide to the above 95% alcohol solution, start stirring to ensure that the liquid is evenly mixed.

[0057] (3) Control of reaction temperature

[0058] Open the steam valve to ensure that the reaction temperature of the tank is 70°C.

[0059] (4) Add sodium hyaluronate powder

[0060] Dispersively add 100kg of sodium hyaluronate powder to the above-mentioned heated alcohol solution containing hydrogen peroxide, the molecular weight of the sodium hyaluronate is 1.5MDa, an...

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Abstract

The invention discloses a technology for preparing low molecular sodium hyaluronate. High molecular hyaluronic acid is degraded by hydrogen peroxide in an organic solvent medium to obtain the low molecular hyaluronic acid having a molecular weight of 5-20 kDa. The technology effectively solves the problems of many extraction impurities, large extraction difficulty and low product purity, and the obtained low molecular hyaluronic acid meets the moisturizing property of hyaluronic acid, has superior permeability, can penetrate into skin stratum corneum, and can be used to directly nutritionallyrepair the skin stratum corneum.

Description

technical field [0001] The invention belongs to the technical field of biochemical industry, and more specifically relates to a preparation process of low-molecular-weight sodium hyaluronate. Background technique [0002] Sodium hyaluronate (Hyaluronic acid, HA), also known as hyaluronic acid, is composed of (1-3)-2-N-acetylamino-2-deoxy-D-glucose-(1-4)-O-β-D- It is an acidic straight-chain polymucopolysaccharide formed by repeated arrangement of disaccharides of glucuronic acid, which has strong hydrophilicity and very good moisturizing performance. It is the substance with the best moisturizing performance found in nature at present. Cosmetics industry recognized as the most ideal natural moisturizing factor, widely used in cosmetics industry. [0003] Low molecular weight sodium hyaluronate is the use of physical, chemical or biological methods to degrade macromolecular hyaluronic acid into sodium hyaluronate with relatively low molecular weight. Low-molecular-weight hy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/08
CPCC08B37/0072
Inventor 李取泉王永贞康传利尤进茂李庆李焕成李娟张梦益刘磊
Owner SHANDONG FOCUSFREDA BIOTECH CO LTD