170 results about "Corneum stratum" patented technology

A device useful for measuring an analyte in the interstitial fluid of an animal comprising an array chamber having an array of one or more microprojections and a detection compartment comprising a sensor in selective fluid communication with the array chamber. Also included are two extraction electrodes for inducing electrotransport of the interstitial fluid from the animal into the array chamber. A method includes the steps of forming a plurality of microchannels through a stratum corneum layer of an epidermis of the animal, inducing electrotransport of interstitial fluid containing the analyte through the microchannels and mixing one or more materials with the interstitial fluid to form a mixture, contacting the mixture with detection electrodes and analyzing the mixture with the detection electrodes.

An applicator for applying a microprojection member to the stratum corneum of a patient having a housing, a piston moveable within the housing and a cap adapted to activate the applicator. The applicator is self-setting and auto-triggering, which allows the applicator to be used by patient's having neither the strength, nor the manual dexterity to pre-set and activate other types of applicator devices.

A retainer (34) is provided for holding a microprotrusion member (44) for application of the microprotrusion member (44) to the stratum corneum with an impact applicator (10). The microprotrusion member (44) includes a plurality of microprotrusions (90) which penetrate the stratum corneum to improve transport of an agent across the stratum corneum.

An apparatus and method for transdermally delivering a vaccine comprising a delivery system having (i) a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers and (ii) an ultrasonic device. In one embodiment, the vaccine is contained in a biocompatible coating that is applied to the microprojection member. In a further embodiment, the delivery system includes a gel pack having a vaccine-containing hydrogel formulation that is disposed on the microprojection member after application to the skin of a patient. In an alternative embodiment, the vaccine is contained in both the coating and the hydrogel formulation.

The invention provides devices for the disruption of one or more layers of skin and methods of their use to administer therapeutic agents, e.g., antigens or drugs. The devices are designed to disrupt a defined area of skin. The defined area can approximate the area that a patch or other suitable vehicle for therapeutic agent, e.g., drug or vaccine, delivery is designed to contact. Exemplary devices employ a mask to define the area to be disrupted. Other devices disrupt a defined area by rotating in place. For devices that employ a mask that is secured to the skin, the invention provides methods of disrupting the stratum corneum by first securing the mask to the skin and then disrupting the skin. For rotating devices, the disrupting member is simply placed against the skin and actuated to effect disruption.

An apparatus for transdermally delivering a biologically active agent comprising (i) a gel pack containing a hydrogel formulation and (ii) a microprojection member having top and bottom surfaces, a plurality of openings that extend through the microprojection member and a plurality of stratum corneum-piercing microprotrusions that project from said bottom surface of the microprojection member, the microprojection member being adapted to receive the gel pack whereby the hydrogel formulation flows through the microprojection member openings. Preferably, the hydrogel formulation comprises a water-based hydrogel.

A topical cosmetic composition including: at least one water-soluble cosmetic agent; at least one oil-soluble cosmetic agent; and a dermal penetration enhancer, wherein topical application of the composition results in the delivery of the water-soluble and oil-soluble cosmetic agents into the stratum corneum as well as delivery of the oil-soluble cosmetic agent into the epidermis and dermis.

A system and method for transdermally delivering a vaccine to a patient including an iontophoresis delivery device having a donor electrode, a counter electrode, and electric circuitry for supplying iontophoresis energy to the electrodes, and a non-electroactive microprojection member having a plurality of stratum corneum-piercing microprojections extending therefrom. The vaccine can be contained in a hydrogel formulation in an agent reservoir disposed proximate the donor electrode, in a biocompatible coating that is disposed on the microprojections or in both.

The skin preparation device and sensor of the present invention include an array of rigid tines. The tines serve to “self-prepare” the skin at each electrode site. These tines, when pressed against the skin, penetrate the stratum corneum, thereby reducing skin impedance and improving signal quality. A self-prepping device of the present invention is an optimized array of short non-conductive rigid tines in which the individual tines are created in a geometry that allows for a sharp point at the tip when molding, machining or etching is used as a method of fabrication. This non-conductive array with rigid penetrating structures may, therefore, be used in combination with a conductive medium, preferably an ionic conductive gel. In penetrating the stratum corneum, micro-conduits are created in the layers of the skin enabling the conductive medium to reach the low impedance layers and to transmit bioelectrical signals from the skin to the electrode surface. Such a self-prepping device can be readily mass produced using molding methods or possibly other manufacturing methods, thereby providing for a low cost means of achieving improved performance of the biopotential sensor. Additionally this invention includes the integration of this self-prepping device into a biopotential sensor comprising an array of one or more electrodes.

In the present invention, the impedance between patient's body and the jet injection drug delivery device is measured through the liquid jet during the drug delivery process. The liquid jet completes the electrical circuit formed by impedance monitor, drug delivery device, and the patient's body. When the jet pierces stratum corneum, the impedance in the circuit immediately decreases, thus an indicating the successful drug delivery. The impedance monitor then provides a signal, visible, audible, or electronic, indicating that the process of the drug delivery through skin was successful.

Apparatus (20) for application to skin of a subject is provided. The apparatus includes a board (30) having a first surface and a second surface, the first surface including a plurality of ablation electrodes (41), which are adapted to be applied to the skin, and the second surface including one or more contact pads (32), each one of the contact pads electrically coupled to at least one of the ablation electrodes. The apparatus further includes one or more driving electrodes (28). An energy applicator (e.g., motor 22), coupled to the driving electrodes, is adapted to pass the driving electrodes over the contact pads. A power source (e.g., power unit 102) is adapted to drive a current from the driving electrodes, to the contact pads, and to the ablation electrodes. The current is capable of ablating at least a portion of stratum corneum of the skin in a vicinity of the ablation electrodes, so as to facilitate transdermal transport of a substance.

Improving fingerprint image measurement despite damage to the stratum corneum. Determining whether a fingerprint image is adequate for matching with a database. If not, re-measure those image portions that are inadequate (overexposed or underexposed), such re-measuring a minimal selection of image portions. An amount of time or power to re-measure is minimized. Improving fingerprint image data collection despite fixed pattern noise like saturated bars in blocks of picture elements. Determining a histogram of grayscale values, removing fixed pattern noise, and expanding real histogram values to obtain more bits of precision.

The present invention teaches apparatus (511) and methods for screening the effect of test formulations on the barrier properties of a membrane (212), that are especially beneficial when skin is used as the test membrane (212). The apparatus (511) and methods enable more efficient measurements of skin permeabilization, of the permeation of molecular or particulate entities through skin, and of the absorption and adsorption by skin of ingredients in fluid formulations, together with screening of exfoliation of material from the exterior of the stratum corneum. The apparatus (511) provide for fluid contact to the skin from both donor and receptor sides, for measurements of skin electrical response in the presence of test formulations, of permeation and permeation enhancement, for the depth profiling of test formulation constituents through the skin, of stratum corneum component disruption, and of loss of material from the stratum corneum.

A draping product (1-4) for surgical interventions, which on its underside is coated with adhesive along at least one edge thereof (5, 6, 7 and 8, respectively), the coating (12) extending fully or partly along the edge. According to the invention, the adherence force against skin of the adhesive is greater than 0.5 N/25 mm and the damage to Stratum Corneum of the part of the skin covered by the adhesive is, after removal of a draping product (1-4) attached to the skin, less than 30 % measured with SCT (Spectroscopic Colour Test).

A low-profile applicator, and a method of manufacturing and use thereof, for impacting microneedles against the stratum corneum of a person having a housing, a diaphragm member having the microneedles, a folding member having interlinking members that hinge-ably rotate with a force member, operatively attached thereto, between a resting position and an extended position. The folding member translates energy stored within the force member when release while retaining the force member in an energized state when in the resting position.

The invention discloses an antibacterial and anti-felting wool fabric finishing method, and belongs to the technical field of spinning. The method includes the steps of firstly, adding hydrogen peroxide and sodium hydroxide to preprocess wool fabric so that scale cells and cortex cells of surfaces of wool fibers can be broken; secondly, conducting enzyme treatment, wherein keratinase and alkaline protease are added for concerted reaction enzymolysis, and after keratin enzymolysis is conducted on the outer layers of scales through keratinase, enzymolysis is conducted on cystine of keratin protein of parts such as inner stratum corneum and cortical layers of wool through alkaline protease; thirdly, conducting chemical finishing, wherein twice soaking and twice rolling are conducted on the wool fabric through a glycerol citric acid ester solution. By means of the method, the effect of increasing wool anti-felting and antibacterial capacity is remarkable, reaction time is short, subsequent processing is simple, the influences on breaking force and whiteness of the processed wool fabric are small, dyeing performance is greatly improved, the directional friction effect is greatly reduced, high economic benefits are achieved, and industrial popularization is facilitated.

The invention relates to a graphene-PDMS flexible substrate electrocardiogram dry electrode based on a tip array structure and a preparation method thereof. a graphene-PDMS flexible substrate is designed on a top surface thereof, a paraxylene film is deposited on tip array structure, metal seed layer is sputtered on paraxylene film, a metal lalyer is sputtered on the metal seed layer. The bottom surface of the graphene-PDMS flexible conductive substrate is coated with a conductive silver paste layer. The process of the invention is simple, the cost is low, and the production of the mould is favorable for batch production. The materials such as conductive silver colloid, PDMS, graphene, paraxylene film and sputtered titanium and gold have good biological compatibility, and can effectively inhibit bacteria and reduce skin irritation. The tip array structure designed by the invention has a larger contact area, and can pass through the stratum corneum by directly contacting with the skin,so that contact impedance of the skin-electrode can be effectively reduced, thus obtaining a stable ECG signal.

The invention discloses a skincare base with effects of preserving moisture, improving wrinkles and resisting oxidation as well as a preparation method and an application of the skincare base. The skincare base comprises components in parts by mass as follows: 2-12 parts of water soluble fullerene, 1-6 parts of Ectoin, 1-20 parts of myrothamnus flabellifolia extract, 0.1-20 parts of soluble proteoglycan, 0.1-20 parts of hydrolyzed elastin, 0.01-1 part of bitter orange flower oil, 0.1-10 parts of PEG-40 hydrogenated castor oil and 10-35 parts of water. By means of interaction of the components,active components of the skincare base can be completely absorbed by skin, moisture content of stratum corneum epidermidis is increased by about 30% after 4-week application and is increased by 35% or more when the skincare base is applied to cosmetics, capacity of resisting oxidation free radicals is increased by 30% and is increased by 40% or more when the skincare base is applied to the cosmetics, and wrinkle reduction rate of the skincare base can reach 20% and is 32% when the skincare base is applied to the cosmetics.

An array of differing microneedles can be accurately achieved including a film having first and second, outwardly facing major surfaces. The first, outwardly facing major surface has a plurality of stratum corneum piercing microneedles extending therefrom, and the plurality of microneedles includes a plurality of first microneedles having a first benefit agent and a plurality of second microneedles having a second benefit agent.