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Preparation method and medicinal use of thiazide compound in Siberian Cocklour Fruit

The technology of Fructus Xanthium and its composition is applied in the preparation of thiazide compounds in Fructus Xanthium, the pharmaceutical composition of rheumatoid arthritis and its preparation, and the field of prevention and/or treatment of rheumatism, which can solve the problem of rheumatism, rheumatoid arthritis Unsatisfactory treatment effect for rheumatoid arthritis, complex chemical composition of cocklebur, etc.

Inactive Publication Date: 2018-09-11
HEILONGJIANG UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Traditional Chinese medicine believes that rheumatism and rheumatoid arthritis are mainly caused by cold, heat, stasis, dampness, and deficiency. For the treatment of inflammation, such as Yu Jianping reported that the external use of Xanthium can be used for the treatment of rheumatoid arthritis, but the chemical components contained in Xanthium are very complex, including volatile oils, fatty acids, glycosides, phenolic acids, thiazide bis Ketones, sesquiterpenes, anthraquinones, flavonoids, alkaloids, etc., the therapeutic effects of different types of ingredients are different, so that the therapeutic effect of cocklebur and its crude extract on rheumatism and rheumatoid arthritis is not ideal, and The effective parts of Xanthium Fructus anti-rheumatism and rheumatoid arthritis have not been reported yet

Method used

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  • Preparation method and medicinal use of thiazide compound in Siberian Cocklour Fruit
  • Preparation method and medicinal use of thiazide compound in Siberian Cocklour Fruit
  • Preparation method and medicinal use of thiazide compound in Siberian Cocklour Fruit

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] Embodiment 1: A kind of tablet that prevents and / or treats rheumatism, rheumatoid arthritis

[0077] Prepare as follows:

[0078] (1) material preparation: take Xanthium Xanthium, pulverize, cross 20 mesh sieves, get Xanthium Xanthium powder;

[0079] (2) Preparation of Xanthium ethanol extract: add 8 times the amount of 70% ethanol to the Xanthium powder obtained in step (1), use the heat reflux method to extract for 2 hours, after filtration, the filtrate recovers ethanol and concentrates to obtain a dry paste;

[0080] (3) Extraction: extract the dry paste obtained in step (2) using petroleum ether, ethyl acetate, and n-butanol in sequence, and obtain different polar parts, namely petroleum ether components (petroleum ether, PE), ethyl acetate Ester component (ethylacetate, EA), n-butanol component (n-Butyl alcohol, BA) and water layer component (water), select n-butanol component, add pharmaceutically acceptable excipients and tablet preparation cost Invention of ...

Embodiment 2

[0081] Embodiment 2: A kind of capsule for preventing and / or treating rheumatism, rheumatoid arthritis

[0082] Prepare as follows:

[0083] (1) material preparation: take Xanthium Xanthium, pulverize, cross 20 mesh sieves, get Xanthium Xanthium powder;

[0084] (2) Preparation of Xanthium ethanol extract: add 8 times the amount of 70% ethanol to the Xanthium powder obtained in step (1), use the heat reflux method to extract for 2 hours, after filtration, the filtrate recovers ethanol and concentrates to obtain a dry paste;

[0085](3) Extraction: extract the dry paste obtained in step (2) using petroleum ether, ethyl acetate, and n-butanol in sequence, and obtain different polar parts, namely petroleum ether components (petroleum ether, PE), ethyl acetate Ethyl acetate component (ethylacetate, EA), n-butanol component (n-Butyl alcohol, BA) and water layer component (water), select ethyl acetate component and n-butanol component, add pharmaceutically acceptable The capsules ...

Embodiment 3

[0086] Embodiment 3: A kind of granule for preventing and / or treating rheumatism, rheumatoid arthritis

[0087] Prepare as follows:

[0088] (1) material preparation: take Xanthium Xanthium, pulverize, cross 20 mesh sieves, get Xanthium Xanthium powder;

[0089] (2) Preparation of Xanthium ethanol extract: add 8 times the amount of 70% ethanol to the Xanthium powder obtained in step (1), use the heat reflux method to extract for 2 hours, after filtration, the filtrate recovers ethanol and concentrates to obtain a dry paste;

[0090] (3) Extraction: extract the dry paste obtained in step (2) using petroleum ether, ethyl acetate, and n-butanol in sequence, and obtain different polar parts, namely petroleum ether components (petroleum ether, PE), ethyl acetate Ethyl acetate component (ethylacetate, EA), n-butanol component (n-Butyl alcohol, BA) and water layer component (water), select the ethyl acetate component, add pharmaceutically acceptable auxiliary materials and prepare t...

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Abstract

The invention relates to a preparation method and a medicinal use of a thiazide compound in Siberian Cocklour Fruit. Effective parts for preventing and / or treating rheumatism and rheumatoid arthritisin ethanol extract of Siberian Cocklour Fruit are screened, ethyl acetate components and n-butanol components in the 50-90% ethanol extract of the Siberian Cocklour Fruit have significant treatment effects on the rheumatism and rheumatoid arthritis, and the n-butanol components in the 50-90% ethanol extract of the Siberian Cocklour Fruit are separated and purified to obtain eleven concrete compounds, the compounds have an obvious inhibition effect on TNF-alpha induced RAFLS cell proliferation, and especially xanthiside has the most obvious effect, and is suitable for preventing and treating the rheumatism and rheumatoid arthritis.

Description

technical field [0001] The present invention belongs to the field of medicine, and in particular relates to a pharmaceutical composition for preventing and / or treating rheumatism and rheumatoid arthritis and its preparation method and application, that is, the preparation method of thiazide compounds in Fructus Xanthii and its medical application . Background technique [0002] Rheumatism and rheumatoid arthritis (Rheumatoid arthritis, RA) are chronic autoimmune diseases mainly characterized by synovitis and progressive joint destruction. Dysfunction, in the late stage, can cause different degrees of stiffness and deformation of the joints, with a high disability rate, and the specific pathogenesis is still unclear. In addition to physical exercise and functional nursing, the current treatment for rheumatism and rheumatoid arthritis generally uses non-steroidal anti-inflammatory drugs, glucocorticoids, immunosuppressants, etc. to control symptoms and relieve patients' pain,...

Claims

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Application Information

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IPC IPC(8): A61K36/28A61P19/02A61P29/00A61K131/00
CPCA61K36/28A61K2236/333A61K2236/35A61K2236/39A61P19/02A61P29/00
Inventor 姜海杨柳
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE
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