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A preparation method of nano-silver and nano-zinc oxide dual-phase deposition of zinc-doped nano-hydroxyapatite and the resulting material

A technology of nano-hydroxyapatite and nano-zinc oxide, which is applied in metal material coating technology, pharmaceutical formulations, liquid chemical plating, etc., can solve the problems of fast release speed, inconspicuous antibacterial effect, inconspicuous long-term antibacterial effect, etc. , to achieve the effect of improving biological activity, improving antibacterial performance and accelerating recovery

Active Publication Date: 2021-08-10
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Due to the large specific surface area of ​​nano-silver and nano-zinc oxide, a low deposition amount will have a strong antibacterial effect, but the release rate is too fast, and the long-term antibacterial effect is not obvious, which is not conducive to the long-term application of nano-hydroxyapatite
Nano-hydroxyapatite doped with zinc ions and other ions with antibacterial effect has long-term antibacterial effect, but the antibacterial effect is not obvious when the doping amount is low, and the purity of nano-hydroxyapatite will be reduced when the doping amount is high, so that A small amount of hydroxyapatite is converted to tricalcium phosphate

Method used

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  • A preparation method of nano-silver and nano-zinc oxide dual-phase deposition of zinc-doped nano-hydroxyapatite and the resulting material
  • A preparation method of nano-silver and nano-zinc oxide dual-phase deposition of zinc-doped nano-hydroxyapatite and the resulting material
  • A preparation method of nano-silver and nano-zinc oxide dual-phase deposition of zinc-doped nano-hydroxyapatite and the resulting material

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Embodiment 1

[0024] A method for preparing zinc-doped nano-hydroxyapatite by dual-phase deposition of nano-silver and nano-zinc oxide, comprising the following steps:

[0025] Step 1: Zinc ion doping: Under rapid stirring conditions, add the phosphoric acid solution containing zinc nitrate dropwise to the calcium hydroxide suspension for reaction. After 6 hours of reaction, pass centrifugation, ball milling, aging, washing, Drying for 12 hours and calcining at 750° C. for 2 hours produces zinc-doped nano-hydroxyapatite.

[0026] Wherein, the molar ratio of the sum of the Zn atoms in the zinc nitrate and the Ca atoms in the calcium hydroxide to the P atoms in the phosphoric acid is 1.67:1. The atomic mass of Zn in zinc nitrate accounts for 0.5% of the atomic mass of Zn in zinc nitrate and the atomic mass of Ca in calcium hydroxide.

[0027] Step 2: nano-zinc oxide deposition: add the product of step 1 into the zinc nitrate solution, and drop an appropriate amount of ammonia water to produc...

Embodiment 2

[0036] A method for preparing zinc-doped nano-hydroxyapatite by dual-phase deposition of nano-silver and nano-zinc oxide, comprising the following steps:

[0037] Step 1: Zinc ion doping: Under rapid stirring conditions, add the phosphoric acid solution containing zinc nitrate dropwise to the calcium hydroxide suspension for reaction. After 6 hours of reaction, pass centrifugation, ball milling, aging, washing, Drying for 12 hours and calcining at 450° C. for 2 hours produces zinc-doped nano-hydroxyapatite.

[0038] Wherein, the molar ratio of the sum of the Zn atoms in the zinc nitrate and the Ca atoms in the calcium hydroxide to the P atoms in the phosphoric acid is 1.67:1. The atomic mass of Zn in zinc nitrate accounts for 1% of the atomic mass of Zn in zinc nitrate and the atomic mass of Ca in calcium hydroxide.

[0039] Step 2: nano-zinc oxide deposition: add the product of step 1 into the zinc nitrate solution, and drop an appropriate amount of ammonia water to produce ...

Embodiment 3

[0046] A method for preparing zinc-doped nano-hydroxyapatite by dual-phase deposition of nano-silver and nano-zinc oxide, comprising the following steps:

[0047] Step 1: Zinc ion doping: Under rapid stirring conditions, add the phosphoric acid solution containing zinc nitrate dropwise to the calcium hydroxide suspension for reaction. After 6 hours of reaction, pass centrifugation, ball milling, aging, washing, Drying for 12 hours and calcining at 600° C. for 2 hours produces zinc-doped nano-hydroxyapatite.

[0048] Wherein, the molar ratio of the sum of the Zn atoms in the zinc nitrate and the Ca atoms in the calcium hydroxide to the P atoms in the phosphoric acid is 1.67:1. The atomic mass of Zn in zinc nitrate accounts for 0.5% of the atomic mass of Zn in zinc nitrate and the atomic mass of Ca in calcium hydroxide.

[0049] Step 2: nano-zinc oxide deposition: add the product of step 1 into the zinc nitrate solution, and drop an appropriate amount of ammonia water to produc...

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Abstract

The invention discloses a method for preparing zinc-doped nano-hydroxyapatite by dual-phase deposition of nano-silver and nano-zinc oxide and its product: first, zinc-doped nano-hydroxyapatite is prepared by ion replacement, and then deposited by deposition The process deposits nano-zinc oxide and nano-silver sequentially on the surface to obtain nano-silver and nano-zinc oxide dual-phase deposition of zinc-doped nano-hydroxyapatite. The present invention realizes zinc doping while depositing nano-zinc oxide and nano-silver on the surface of hydroxyapatite. The doping of zinc can improve the biological activity and antibacterial performance of hydroxyapatite, and can also promote the deposition of nano-zinc oxide on the surface of hydroxyapatite, strengthen the efficient antibacterial effect of nano-zinc oxide and nano-silver, and realize Long-acting antibacterial. At the same time, doped zinc and deposited nano-zinc oxide can promote the proliferation of bone cells on nano-hydroxyapatite and accelerate the recovery of fractures.

Description

technical field [0001] The invention relates to a preparation method of nano-silver and nano-zinc oxide dual-phase deposition of zinc-doped nano-hydroxyapatite and the obtained material, belonging to the field of biomedical material preparation. Background technique [0002] Hydroxyapatite is the main inorganic component of vertebrate bones and teeth, accounting for about 65% of the total bone mass. Synthetic nano-hydroxyapatite is very close to the apatite crystal in human natural bone in structure and composition, and can maintain stable thermodynamic properties in physiological environments, and has good biocompatibility, bioactivity and bone Conductivity, is widely used in drug carriers, orthopedics, bone repair materials and dental materials. However, in clinical use, bacterial infection is the main factor restricting the wide application of nano-hydroxyapatite. Therefore, modification of nano-hydroxyapatite to have antibacterial properties can make it more widely used...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12A61L27/04A61L27/02A61L27/50A61L27/54C23C18/44C23C18/12
CPCA61L27/025A61L27/047A61L27/12A61L27/50A61L27/54A61L2300/102A61L2300/104A61L2300/404A61L2400/12A61L2430/02C23C18/1216C23C18/1245C23C18/44
Inventor 郭超库勇昌林萍华董寅生储成林盛晓波黄志海
Owner SOUTHEAST UNIV
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