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Solid-phase polypeptide synthesis device

A solid-phase peptide synthesis and peptide synthesis technology, applied in the fields of peptides, peptide preparation methods, organic chemistry, etc., can solve the problems of inconvenient use, expensive peptide synthesizers, inability to customize research requirements, etc. Product quality, the effect of avoiding damage

Pending Publication Date: 2018-10-19
南京肽业生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Commercial peptide synthesizers are expensive and cannot be customized according to research needs, making them inconvenient to use in scientific research

Method used

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  • Solid-phase polypeptide synthesis device
  • Solid-phase polypeptide synthesis device
  • Solid-phase polypeptide synthesis device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] see Figure 1-5 , a solid-phase peptide synthesis device, including a peptide synthesis tube 1, a synthesis tube holder 2, a nitrogen tank 3 and a waste liquid collection bottle 4;

[0026] The polypeptide synthesis tube 1 is provided with a sand core plate 13, the sand core plate 13 separates the polypeptide synthesis tube 1 into a reaction zone 11 and a buffer zone 12, the upper end of the polypeptide synthesis tube 1 is open, and the reaction zone 11 A rotating motor 15 is arranged directly above, and a rotating shaft 16 connected to the rotating motor 15 extends vertically into the reaction zone 11. A plurality of sets of inclined fixed rods 17 are evenly arranged at the bottom of the rotating shaft 16, and the upper ends of the fixed rods 17 are fixed on the rotating shaft. On the shaft 16, the lower end is fixed on the inner wall of the polypeptide synthesis tube 1 in the reaction zone 11;

[0027] The outer shape of the buffer zone 12 is a downwardly convex hemi...

Embodiment 2

[0033] see Figure 1-5 , as an improvement of the present invention, the solid-phase polypeptide synthesis device further includes a rotating motor fixing frame 5, and the casing of the rotating motor 15 is fixed on the rotating motor fixing frame 5. Enhance the stability of device operation.

Embodiment 3

[0035] see Figure 1-5 , as an improvement of the present invention, the gas pipelines 322 of the nitrogen heating device 32 are arranged in a "back shape" in the casing 321 . Maximize the use of space and improve the efficiency of nitrogen heating.

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Abstract

The invention belongs to the technical field of polypeptide synthesis equipment, and particularly relates to a solid-phase polypeptide synthesis device. The solid-phase polypeptide synthesis device comprises a polypeptide synthesis tube, a synthesis tube fixed base, a nitrogen tank and a waste liquid collection bottle, wherein a buffering area of the polypeptide synthesis tube is mounted in a base; a vaseline layer is arranged between the outer wall of the buffering area and the inner wall of the base; the outer wall of the buffering area and the inner wall of the base can be movably connectedtogether through the vaseline layer; the outer wall of the buffering area can be rotated relative to the base and simultaneously has airtightness; through arrangement of a rotary motor connected withthe polypeptide synthesis tube, solid-liquid separation can be carried out through rotating centrifugation, waste liquid is removed, washing is convenient to carry out, and the conditions that the use of a vacuum pump is easily damaged and the vacuum pump is higher in cost are avoided; through arrangement of a nitrogen heating device, reaction liquid is stirred by using hot nitrogen, and an appropriate temperature is provided for polypeptide synthesis, so that the quality of a product is improved, and the reaction efficiency is improved.

Description

technical field [0001] The invention belongs to the technical field of polypeptide synthesis equipment, and in particular relates to a solid-phase polypeptide synthesis device. Background technique [0002] Polypeptide solid-phase synthesis method - English explanation: solid phase peptide synthesis is abbreviated as SPPS. This synthesis method has a milestone significance in peptide chemistry. It started a revolution in the organic synthesis of peptides and became an independent discipline - solid-phase organic synthesis (SPOS). [0003] The advantage of solid-phase synthesis is that the initial reactants and products are connected to the solid-phase carrier, so all reactions can be carried out in one reaction vessel, which is convenient for automatic operation, and high-yield products can be obtained by adding excess reactants , and the products are easily separated. Chemically synthesized peptides can now be performed on program-controlled automated peptide synthesizers...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K1/04
CPCC07K1/04
Inventor 徐红岩马连芹徐大为杨明
Owner 南京肽业生物科技有限公司