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Microfluid flow on-line regulating device and detection method

A regulating device and microfluidic technology, applied in the field of microfluidics, can solve the problem that the ideal output flow of a pressure driving device is difficult to accurately calculate, and achieve the effects of online rapid detection, high measurement accuracy, and stable regulation

Inactive Publication Date: 2020-05-05
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as the driving pressure increases, the microfluidic flow has nonlinear characteristics, and the ideal output flow of the pressure-driven device is difficult to calculate accurately

Method used

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  • Microfluid flow on-line regulating device and detection method
  • Microfluid flow on-line regulating device and detection method
  • Microfluid flow on-line regulating device and detection method

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specific Embodiment approach 1

[0025] Specific implementation mode one: the following combination figure 1 and figure 2 Describe this embodiment, the microfluid flow rate online adjustment device and detection method described in this embodiment, it consists of a gas supply source 1, a pressure reducing valve 2, a proportional pressure valve 3, a first liquid container 4, a valve 5, a first pressure A sensor 6, a second pressure sensor 7, a microfluidic channel 8, a microfluidic chip 9, a second liquid container 10, a weighing instrument 11 and a microprocessor 12 are formed. in:

[0026] The gas inlet of the pressure reducing valve 2 is communicated with the compressed air outlet of the gas supply source 1, and the gas outlet of the pressure reducing valve 2 is communicated with the gas inlet of the proportional pressure valve 3;

[0027] The gas outlet of the proportional pressure valve 3 communicates with the gas inlet of the first liquid container 4, and the liquid outlet of the first liquid containe...

specific Embodiment approach 2

[0037] Specific implementation mode two: the following combination figure 2 This embodiment will be described, and this embodiment will further describe the first specific embodiment. In order to ensure that the microfluid flow has a linear relationship with the pressure difference at both ends of the microfluid channel 8 (the microfluid flow Q = scale factor K × differential pressure ΔP ), to realize the online accurate detection of the microfluidic flow rate, the microfluidic channel 8 adopts the PTFE round tube structure, and the length of the round tube is required L with inner diameter d The ratio is greater than 20:1, and the Reynolds number Re <1.0 of the microfluid flow is satisfied inside the circular tube, and the microfluid is in a laminar flow state.

[0038] In this embodiment, the inner diameter of the PTFE round tube d The range of change is 0.1 ~ 1.0 mm, the length of PTFE round tube L The variation range of 10.0 ~ 40.0 mm, according to the microfluidic...

specific Embodiment approach 3

[0039] Specific implementation mode three: the following combination image 3This embodiment will be described, and this embodiment will further describe the first specific embodiment. In order to realize online stable regulation of the microfluidic flow rate, the first pressure sensor 6 and the second pressure sensor 7 respectively measure the inlet and outlet pressures of the microfluidic channel 8 to obtain the pressure difference at both ends of the microfluidic channel 8 and feed it back to the microprocessor 12, The control signal is output by the microprocessor 12 to change the gas control pressure of the proportional pressure valve 3 and adjust the microfluid flow online.

[0040] In this embodiment, the online adjustment time of the microfluid flow is less than 0.5 s, and the online adjustment accuracy of the microfluid flow reaches 0.1%.

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Abstract

The invention discloses a microfluid flow online adjusting device and a detection method. The microfluid flow online adjusting device comprises a gas supply source, a pressure reducing valve, a proportional pressure valve, a first liquid container, a valve, a first pressure sensor, a second pressure sensor, a microfluid channel, a micro-fluidic chip, a second liquid container, a weighing instrument and a microprocessor, wherein the pressure reducing valve communicates with the gas supply source and a gas inlet of the proportional pressure valve, the proportional pressure valve communicates with the first liquid container, the first liquid container communicates with the valve, the valve communicates with the microfluid channel, the microfluid channel communicates with the micro-fluidic chip, the micro-fluidic chip communicates with the second liquid container, the first pressure sensor is arranged at an inlet of the microfluid channel, the second pressure sensor is arranged at an outlet of the microfluid channel, the second liquid container is placed on the weighing instrument, the pressure sensor is connected with the microprocessor, and the microprocessor is connected with the proportional pressure valve. The microfluid flow online adjusting device is capable of realizing on-line stable adjustment and accurate measurement of the microfluid flow, has the advantages that the microfluid flow adjustment is stable, the detection speed is high, and the detection precision is high, and provides technical support for promoting application research of a micro-fluidic system in the cross disciplinary field.

Description

technical field [0001] The invention relates to a microfluid flow online regulating device and a detection method, belonging to the microfluid field. Background technique [0002] Syringe pumps are commonly used flow regulating components in microfluidic systems. The syringe pump is driven by a stepping motor, and the ideal value of the output flow of the syringe pump can be calculated by selecting the diameter of the syringe and setting the speed of the stepping motor. However, the use of syringe pumps to adjust the microfluidic flow of the microfluidic system has many disadvantages, such as: the actual output flow has periodic pulsations, the flow cannot be detected online, the flow adjustment speed is slow, and the accuracy is low. With the wide application of microfluidic systems in the fields of chemistry, biology, and medicine, pressure-driven microfluidic flow regulators can replace syringe pumps to achieve stable flow regulation in microfluidic systems. The pressur...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): F17D3/01
CPCF17D3/01
Inventor 曾文魏欣彤
Owner HARBIN INST OF TECH
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