Multifunctional coating applicable to medical implantable device

A multi-functional coating and functional technology, applied in coatings, medical science, prostheses, etc., can solve problems such as antibiotic resistance and weakened antibacterial efficiency of coatings, and achieve simple equipment and promote cell adhesion and proliferation and anti-fouling performance, the effect of a wide range of monomer sources

Inactive Publication Date: 2018-11-16
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, use of antibiotics may lead to antibiotic resistance
In addition, the accumulation of dead bacteria and the subsequent formation of bacterial film may lead to the weakening of the antimicrobial efficiency of the coating

Method used

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  • Multifunctional coating applicable to medical implantable device
  • Multifunctional coating applicable to medical implantable device
  • Multifunctional coating applicable to medical implantable device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A multifunctional coating applicable to medical implant devices and a preparation method thereof, the specific steps are as follows:

[0039] Step a) Synthesis of amphiphilic zwitterionic functional polymer: Weigh 2.201g (14mmol) dimethylaminoethyl methacrylate, 1.250g (6mmol) isobornyl acrylate and 0.034g (1%) 2,2- Azobisisobutyronitrile was added to 20 mL of dioxane, deoxygenated by nitrogen gas for 30 min, and reacted at 65°C for 24 h. After the reaction, the precipitation was repeated three times in petroleum ether to obtain a spare polymer. Dissolve 2 g of spare polymer in 10 mL of dioxane, add 0.071 g of propane sultone, and react at room temperature for 12 hours. After the reaction, the reaction solution is concentrated by rotary evaporation, precipitated in ether three times, and dried in vacuo Finally, an amphiphilic zwitterionic functional polymer with a sulfonation rate of 10% is obtained.

[0040] Step b) preparation of the complex colloid solution: dissol...

Embodiment 2

[0043] A multifunctional coating applicable to medical implant devices and a preparation method thereof, the specific steps are as follows:

[0044] Step a) Synthesis of amphiphilic zwitterionic functional polymer: Weigh 1.572g (10mmol) dimethylaminoethyl methacrylate, 2.083g (10mmol) isobornyl acrylate and 0.068g (1.5%) 2,2- Azobisisobutyronitrile was added to 20 mL of dioxane, deoxygenated by nitrogen gas for 30 min, and reacted at 65°C for 24 h. After the reaction, the precipitation was repeated three times in petroleum ether to obtain a spare polymer. Dissolve 2 g of spare polymer in 10 mL of dioxane, add 0.212 g of propane sultone, and react at room temperature for 12 hours. After the reaction, the reaction solution is concentrated by rotary evaporation, precipitated in ether three times, and dried in vacuo Finally, an amphiphilic zwitterionic functional polymer with a sulfonation rate of 30% is obtained.

[0045] Step b) Preparation of the complex colloid solution: Dis...

Embodiment 3

[0048] A multifunctional coating applicable to medical implant devices and a preparation method thereof, the specific steps are as follows:

[0049] Step a) Synthesis of amphiphilic zwitterionic functional polymer: Weigh 0.944g (6mmol) dimethylaminoethyl methacrylate, 2.916g (14mmol) isobornyl acrylate and 0.068g (1.5%) 2,2- Azobisisobutyronitrile was added to 20 mL of dioxane, deoxygenated by nitrogen gas for 30 min, and reacted at 70°C for 24 h. After the reaction, the precipitation was repeated three times in petroleum ether to obtain a spare polymer. Dissolve 2 g of spare polymer in 10 mL of dioxane, add 0.353 g of propane sultone, and react at room temperature for 12 hours. After the reaction, the reaction solution is concentrated by rotary evaporation, precipitated in ether three times, and dried in vacuo Finally, an amphiphilic zwitterionic functional polymer with a sulfonation rate of 50% is obtained.

[0050] Step b) Preparation of the complex colloid solution: Diss...

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Abstract

The invention discloses a multifunctional coating applicable to a medical implantable device and belongs to the technical field of coating materials. A method comprises steps as follows: firstly, an amphiphilic functional zwitterionic copolymer is synthesized, a tannic acid ethanol solution is dropwise added to zwitterionic random copolymer ethanol under the stirring condition, and a compound colloidal solution is formed through co-assembly; finally, the compound colloidal solution is taken as an electrolyte solution, and a nanocoating is prepared on the surface of a medical alloy with an electrophoretic deposition technology. The method is simple and convenient to operate and applicable to a wide substrate range; by means of the coating, cell adhesion and proliferation are improved, meanwhile, the coating has better antifouling capability, has a good adhesion inhibiting function on escherichia coli, staphylococcus aureus, protein and the like, has certain bactericidal activity to killbound bacteria and is expected to be applied to the fields of bone substitute repairing materials, organ and cavity scaffolds and the like.

Description

technical field [0001] The invention relates to a multifunctional coating applicable to medical implantation devices, belonging to the technical field of coating materials. Background technique [0002] Bacterial anchoring and subsequent biofilm formation on the surface of medical materials seriously affects their clinical application, especially for metal implant materials such as titanium alloy, magnesium alloy and 316L stainless steel, etc. Facing the problem of implantation infection, only by meeting the antibacterial requirements at the initial stage of implantation can it be used as a medical implant material in the fields of related tissue repair and official cavity stents in the human body. One of the commonly used methods at present is to prepare coatings containing antibiotics, such as gentamicin, vancomycin and the like. However, antibiotic use can lead to antibiotic resistance. In addition, the accumulation of dead bacteria and the subsequent formation of bacte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/34A61L27/54C08F220/18C08F220/34
CPCA61L27/34A61L27/54A61L2300/216A61L2300/404A61L2300/606C08F220/18C08F220/1811C08L33/08C08F220/34
Inventor 朱叶孟龙刘晓亚李杨魏玮李小杰
Owner JIANGNAN UNIV
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