Insulin skin medication paste for diabetes and preparation method

A technology of transdermal drug delivery and insulin, which is applied in the medical field, can solve the problems of skin that is difficult to penetrate oil, can not effectively exert the drug effect, and restricts the development and application, so as to increase the transdermal property, increase the transdermal efficacy, and have a good application prospect Effect

Inactive Publication Date: 2018-11-20
CHENDU NEW KELI CHEM SCI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] It can be seen that the insulin in the prior art has brought great pain to the patient due to long-term injection, and even adverse reactions such as allergy, induration, inflammation, etc., and when administere

Method used

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  • Insulin skin medication paste for diabetes and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] a. Dissolve insulin in triethanolamine-hydrochloric acid buffer solution, then add polylactic acid hollow fiber, through vacuum treatment, make insulin enter the hollow hole of polylactic acid hollow fiber, and make polylactic acid fiber containing insulin; polylactic acid hollow fiber The pore size is 30~50nm.

[0033] B, mixing the insulin-containing polylactic acid fiber prepared in step a with sodium salicylate, sitosterol, lecithin, ceramide, ethyl cellulose, glycerin, and mixing it into a gel compound paste;

[0034] c. Apply the gel compound paste prepared in step b on the surface of the base material under air-isolated conditions, then paste the diaphragm, cut it and package it in a plastic package to obtain an insulin transdermal drug delivery patch.

[0035] In step c, the substrate is a PU film; in step c, the diaphragm is a polylactic acid film;

[0036] In step a, in triethanolamine-hydrochloric acid buffer, 22 parts by weight of triethanolamine, 14 parts ...

Embodiment 2

[0039] a. Dissolve insulin in triethanolamine-hydrochloric acid buffer solution, then add polylactic acid hollow fiber, through vacuum treatment, make insulin enter the hollow hole of polylactic acid hollow fiber, and make polylactic acid fiber containing insulin; polylactic acid hollow fiber The pore size is 30~50nm.

[0040] B, mixing the insulin-containing polylactic acid fiber prepared in step a with sodium salicylate, sitosterol, lecithin, ceramide, ethyl cellulose, glycerin, and being formulated into a gel compound paste;

[0041] c. Apply the gel compound paste prepared in step b on the surface of the base material under air-isolated conditions, then paste the diaphragm, cut it and package it in a plastic package to obtain an insulin transdermal drug delivery patch.

[0042] In step c, the substrate is a PU film; in step c, the separator is a starch-modified polyvinyl alcohol film;

[0043] In step a, in triethanolamine-hydrochloric acid buffer, 20 parts by weight of tri...

Embodiment 3

[0046] a. Dissolve insulin in triethanolamine-hydrochloric acid buffer solution, then add polylactic acid hollow fiber, through vacuum treatment, make insulin enter the hollow hole of polylactic acid hollow fiber, and make polylactic acid fiber containing insulin; polylactic acid hollow fiber The pore size is 30~50nm.

[0047] B, mixing the insulin-containing polylactic acid fiber prepared in step a with sodium salicylate, sitosterol, lecithin, ceramide, ethyl cellulose, glycerin, and mixing it into a gel compound paste;

[0048] c. Apply the gel compound paste prepared in step b on the surface of the base material under air-isolated conditions, then paste the diaphragm, cut it and package it in a plastic package to obtain an insulin transdermal drug delivery patch.

[0049] In step c, the substrate is a PU film; in step c, the diaphragm is a polylactic acid film;

[0050] In step a, in triethanolamine-hydrochloric acid buffer, 25 parts by weight of triethanolamine, 15 parts ...

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Abstract

The invention discloses an insulin skin medication paste for diabetes and a preparation method. The insulin skin medication paste is prepared by the following steps: a, dissolving insulin into a triethanolamine-hydrochloric acid buffer liquid, adding a polylactic acid hollow fiber, and carrying out vacuum treatment so as to obtain a polylactic acid fiber with insulin; b, mixing the polylactic acidfiber with sodium salicylate, sitosterol, lecithin, ceramide, ethyecellulose and glycerinum so as to obtain a composite gel ointment; c, under an air isolated condition, coating the surface of a substrate by the composite gel ointment, adhering to a diaphragm, cutting, and packaging, thereby obtaining the insulin skin medication paste. The preparation method has the beneficial effects that the insulin skin medication paste disclosed by the invention has a slow release effect, through micro acupuncturing of the polylactic acid fiber and a skin expansion function of salicylic acid, the skin medication effect of the paste can be effectively improved, and the paste is applicable to an abdomen part, has long-lasting medicinal effects, is very convenient to use and has good application prospects.

Description

technical field [0001] The invention relates to the medical field, in particular to the preparation of diabetes drugs, in particular to an insulin transdermal drug delivery patch for diabetes and a preparation method thereof. Background technique [0002] Topical transdermal administration is a drug delivery method in which drugs are absorbed through the skin. After the drug is applied to the skin, it passes through the stratum corneum, diffuses through the skin, and activates the effect of treating diseases locally or systemically. Compared with traditional oral or injection administration, transdermal administration has many advantages, such as maintaining effective drug concentration through continuous transdermal action, reducing toxic and side effects, avoiding drug degradation and absorption in the gastrointestinal tract, and improving drug delivery. Utilization rate, patients can self-administer medication or withdraw medication at any time. [0003] However, due to ...

Claims

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Application Information

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IPC IPC(8): A61K38/28A61K9/70A61K47/34A61K47/12A61P3/10
CPCA61K38/28A61K9/0021A61K9/0092A61K9/70A61K47/12A61K47/34A61P3/10
Inventor 陈庆曾军堂
Owner CHENDU NEW KELI CHEM SCI CO LTD
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