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Conductive polymer microneedle electrode used for biomolecular detection and preparation method thereof

A technology of conductive polymers and biomolecules, applied in the direction of measuring devices, analytical materials, and electrochemical variables of materials, can solve the problem of poor biocompatibility of metal electrodes, low structural design and application flexibility, and influence of bioelectrical signals Collection and other problems, to achieve good biocompatibility, solve the effect of poor biocompatibility and low price

Inactive Publication Date: 2018-11-20
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The penetrating microneedle electrode effectively solves the problem of high skin impedance and realizes the collection of bioelectrical signals, such as patents CN103263727, CN102727992A, US20100130940 and CN1415385A, which mainly use metal microneedle electrodes, which have good mechanical properties and are easy to pierce the skin The dense stratum corneum, but the biocompatibility of the metal material electrode is not good. Long-term penetration into the skin will cause skin allergies and inflammation, and the rejection of the body will promote a large number of white blood cells to accumulate on the surface of the microneedle, which will affect the collection of bioelectrical signals. , and the preparation process is complicated, the cost is high, and the flexibility of structure design and application is low

Method used

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  • Conductive polymer microneedle electrode used for biomolecular detection and preparation method thereof
  • Conductive polymer microneedle electrode used for biomolecular detection and preparation method thereof
  • Conductive polymer microneedle electrode used for biomolecular detection and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0030] (1) Mix the liquid polydimethylsiloxane prepolymer and the curing agent in a mass ratio of 10:1, stir evenly, and then vacuumize to remove the air bubbles, then pour it into a horizontally placed container. Put the container in an oven at 60°C and heat it for 5-10 hours to obtain a polydimethylsiloxane sheet with uniform thickness; then take the sheet out of the container and put it into the working chamber of the laser engraving machine. The laser parameters are adjusted according to the needle geometry, and the polydimethylsiloxane sheet is micro-nano-processed to prepare a micro-needle template;

[0031] (2) Place an appropriate amount of polylactic acid solid particles on the microneedle template, then put the template into an oven at 200°C and heat it for a period of time. After the polylactic acid is fully melted, take out the template, mold it while the polylactic acid is melting, and cool to After demoulding at room temperature, a solid polymer microneedle with ...

Embodiment 2

[0036] (1) Mix the liquid polydimethylsiloxane prepolymer and the curing agent in a mass ratio of 10:1, stir evenly, and then vacuumize to remove the air bubbles, then pour it into a horizontally placed container. Put the container in an oven at 60°C and heat it for 5-10 hours to obtain a polydimethylsiloxane sheet with uniform thickness; then take the sheet out of the container and put it into the working chamber of the laser engraving machine. The laser parameters are adjusted according to the needle geometry, and the polydimethylsiloxane sheet is micro-nano-processed to prepare a micro-needle template;

[0037](2) Place an appropriate amount of polylactic acid solid particles on the microneedle template, and then put the template into an oven at 200°C and heat it for a period of time. After the polylactic acid is fully melted, take out the template and mold it while the polylactic acid is melting. After cooling to room temperature, the solid polymer microneedle with the bas...

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Abstract

The invention relates to a conductive polymer microneedle electrode used for biomolecular detection and a preparation method thereof. The conductive polymer microneedle electrode is an electrode- microneedle integrated electrode product, and consists of a polymer solid microneedle, an inert metal layer and a conductive polymer film fixing bioactive molecules. The conductive polymer film can be deposited on the polymer microneedle in an electrochemistry manner, and the collection of bioelectrical signals can be realized by using the microneedle to pierce the skin, so that the conductive polymermicroneedle electrode can have characteristics of efficient and painless. Bioactive components can be fixed in the conductive polymer film, so that specific recognition can be performed on to-be-detected biomolecules, and electrical signal sensitivity can be greatly enhanced. The conductive polymer microneedle electrode is simple in preparation technology and low in price; and conductive polymershave good biocompatibility and are insoluble in body after being pierced in the skin, and real-time detection and longtime continuous monitoring of the biomolecules can be realized.

Description

technical field [0001] The invention belongs to the technical field of bioelectrical signal detection, and specifically relates to a conductive polymer microneedle electrode for biomolecular detection and a preparation method thereof. The electrode is composed of a polymer solid microneedle, an inert metal layer, a fixed Conductive polymer film layer composed of biologically active molecules. Background technique [0002] In recent years, with the continuous development and maturity of Micro-Electro-Mechanical Systems (MEMS: Micro-Electro-Mechanical Systems) technology, the application range of micro-sensors has been continuously expanded, and they are widely used in fields such as medicine and environmental detection. The research on microelectrodes has also developed rapidly. [0003] At present, the difficulties encountered in the signal acquisition of electrodes used for biomolecular detection are (1) weak bioelectrical signals; (2) high impedance of signal sources, com...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/327G01N27/30
CPCG01N27/307G01N27/327
Inventor 郭新东金旋杨圆
Owner BEIJING UNIV OF CHEM TECH
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