A kind of artificial skin and preparation method thereof

A technology of artificial skin and dense film, which is applied in the field of medical assistance, can solve the problems of hindering the growth of body skin, disorderly degradation, skin graft failure, etc., and achieve good layer-by-layer degradation, good drug slow and controlled release, and promote wound healing.

Active Publication Date: 2019-06-14
HARBIN INST OF TECH AT WEIHAI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After the completion of skin grafting, the existing artificial skin often has poor antibacterial function, which leads to wound infection and ulceration, or disorderly degradation, which hinders the growth of its own skin and eventually leads to skin grafting failure. The phenomenon of the above-mentioned problems in transplantation is particularly obvious

Method used

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  • A kind of artificial skin and preparation method thereof
  • A kind of artificial skin and preparation method thereof
  • A kind of artificial skin and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Depend on Figure 1-Figure 5 As shown, the present invention provides an artificial skin, which consists of a double-layer structure consisting of a protective film layer 1, a dense film layer 2, and a filling compound 3. The protective film layer 1 is coated and connected to the upper surface of the dense film layer 2.

[0046] Depend on Figure 1-Figure 10 As shown, the protective film layer 1 is made of wormwood extract. The dense membrane layer 2 has a porous membrane structure, and the dense membrane layer 2 is formed by mixed fusion deposition molding of polycarboxylic anhydride and polyethylene succinate. The dense film layer 2 is provided with a first printing layer 5 and a second printing layer 6, and the printing lines of the first printing layer 5 and the second printing layer 6 are formed by bow-shaped folding, and the bow-shaped folding of the printing wire of the first printing layer 5 Form the first arcuate recessed part 7, the first arcuate recessed pa...

preparation Embodiment 1

[0051] The method for preparing the artificial skin described in embodiment 1, it may further comprise the steps:

[0052](1), according to the parts by weight, respectively weigh the production raw materials of the protective film layer 1: 1 part of wormwood extract, an appropriate amount of deionized water;

[0053] Weigh the raw materials for making dense film layer 2: 20 parts of polycarboxylic anhydride, 20 parts of polyethylene succinate; 20 parts of collagen; 10 parts of polylysine; 10 parts of glycine; 5 parts of gum arabic; 5 parts of citric acid 15 parts of traditional Chinese medicine extracts with antibacterial and antiviral effects, including 10 parts of wormwood extracts, 5 parts of other traditional Chinese medicine extracts with antibacterial and antiviral effects, which are peppermint extracts; appropriate amount of deionized water.

[0054] (2), mix the raw materials polycarboxylate and polyethylene succinate of the dense film layer 2 weighed in step (1), and...

Embodiment 3

[0062] The method for preparing the artificial skin described in embodiment 1, it may further comprise the steps:

[0063] (1), according to parts by weight, weigh the raw materials for making protective film layer 1 respectively: 5 parts of wormwood extract, appropriate amount of deionized water;

[0064] Take by weighing the raw materials for making dense film layer 2: 50 parts of polycarboxylic anhydride, 50 parts of polyethylene succinate; 50 parts of collagen; 30 parts of polylysine; 20 parts of glycine; 10 parts of gum arabic; 10 parts of citric acid 25 parts of traditional Chinese medicine extracts with antibacterial and antiviral effects, including 20 parts of wormwood extracts, 5 parts of other traditional Chinese medicine extracts with antibacterial and antiviral effects, including 4 parts of peppermint extracts and 1 part of Daqingye extract; Appropriate amount of deionized water.

[0065] (2), mix the raw materials polycarboxylate and polyethylene succinate of the...

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Abstract

The invention provides an artificial skin and a preparation method thereof, which solves the technical problem that the existing artificial skin often has poor antibacterial function after skin grafting, or the artificial skin has poor antibacterial function or disorderly degradation, which leads to the failure of skin grafting. A double-layer structure composed of a dense film layer and a filling compound. The protective film layer is coated and connected to the upper surface of the dense film layer. The dense film layer is a porous film structure. The dense film layer is provided with mesh pores along the three-dimensional direction. The connections in the pores are filled with filling compounds; the protective film layer is wormwood extract, the dense film layer is made of polycarboxylic anhydride and polyethylene succinate mixed fusion deposition molding, and the filling compound is made of collagen, polylysine acid, glycine, gum arabic, citric acid, and traditional Chinese medicine extracts with antibacterial and antiviral effects. The invention also provides a preparation method for artificial skin, which can be widely used in the field of medical auxiliary technology.

Description

technical field [0001] The invention relates to the technical field of medical assistance, in particular to an artificial skin and a preparation method thereof. Background technique [0002] The skin is the largest organ of the human body. It not only has the function of resisting external environmental infections, but also undertakes the task of preventing the loss of water, electrolytes and other substances in the body. Under normal circumstances, if the skin is slightly damaged, it can recover by itself. When a large area of ​​skin is severely burned or damaged, the doctor must immediately infuse fluids and protect the wound. If only the superficial layer of the skin is damaged, the new skin will regeneration. If a patient has suffered a severe burn and the skin cannot repair itself, superficial skin from another part of the body is usually grafted over the wound, but this method can cause new scars. Moreover, if it is a large area of ​​burns, there will be very little ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/60A61L27/54A61L27/40
CPCA61L27/18A61L27/20A61L27/24A61L27/3637A61L27/54A61L27/60A61L2300/30A61L2300/404C08L77/04C08L67/04C08L5/00
Inventor 张鹏刘康王传杰孙金平陈刚
Owner HARBIN INST OF TECH AT WEIHAI
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