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Artificial skin as well as preparation method thereof

An artificial skin and dense film technology, applied in the field of medical assistance, can solve the problems of hindering the growth of the body skin, degrading disorder, skin grafting failure, etc., and achieves the effect of promoting wound healing, good slow-controlled drug release, and good layer-by-layer degradation.

Active Publication Date: 2018-11-23
HARBIN INST OF TECH AT WEIHAI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After the completion of skin grafting, the existing artificial skin often has poor antibacterial function, which leads to wound infection and ulceration, or disorderly degradation, which hinders the growth of its own skin and eventually leads to skin grafting failure. The phenomenon of the above-mentioned problems in transplantation is particularly obvious

Method used

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  • Artificial skin as well as preparation method thereof
  • Artificial skin as well as preparation method thereof
  • Artificial skin as well as preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Depend on Figure 1-Figure 5 As shown, the present invention provides an artificial skin, which consists of a double-layer structure consisting of a protective film layer 1, a dense film layer 2, and a filling compound 3. The protective film layer 1 is coated and connected to the upper surface of the dense film layer 2.

[0046] Depend on Figure 1-Figure 10 As shown, the protective film layer 1 is made of wormwood extract. The dense membrane layer 2 has a porous membrane structure, and the dense membrane layer 2 is formed by mixed fusion deposition molding of polycarboxylic anhydride and polyethylene succinate. The dense film layer 2 is provided with a first printing layer 5 and a second printing layer 6, and the printing lines of the first printing layer 5 and the second printing layer 6 are formed by bow-shaped folding, and the bow-shaped folding of the printing wire of the first printing layer 5 Form the first arcuate recessed part 7, the first arcuate recessed pa...

preparation Embodiment 1

[0051] The method for preparing the artificial skin described in embodiment 1, it may further comprise the steps:

[0052](1), according to the parts by weight, respectively weigh the production raw materials of the protective film layer 1: 1 part of wormwood extract, an appropriate amount of deionized water;

[0053] Weigh the raw materials for making dense film layer 2: 20 parts of polycarboxylic anhydride, 20 parts of polyethylene succinate; 20 parts of collagen; 10 parts of polylysine; 10 parts of glycine; 5 parts of gum arabic; 5 parts of citric acid 15 parts of traditional Chinese medicine extracts with antibacterial and antiviral effects, including 10 parts of wormwood extracts, 5 parts of other traditional Chinese medicine extracts with antibacterial and antiviral effects, which are peppermint extracts; appropriate amount of deionized water.

[0054] (2), mix the raw materials polycarboxylate and polyethylene succinate of the dense film layer 2 weighed in step (1), and...

Embodiment 3

[0062] The method for preparing the artificial skin described in embodiment 1, it may further comprise the steps:

[0063] (1), according to parts by weight, weigh the raw materials for making protective film layer 1 respectively: 5 parts of wormwood extract, appropriate amount of deionized water;

[0064] Take by weighing the raw materials for making dense film layer 2: 50 parts of polycarboxylic anhydride, 50 parts of polyethylene succinate; 50 parts of collagen; 30 parts of polylysine; 20 parts of glycine; 10 parts of gum arabic; 10 parts of citric acid 25 parts of traditional Chinese medicine extracts with antibacterial and antiviral effects, including 20 parts of wormwood extracts, 5 parts of other traditional Chinese medicine extracts with antibacterial and antiviral effects, including 4 parts of peppermint extracts and 1 part of Daqingye extract; Appropriate amount of deionized water.

[0065] (2), mix the raw materials polycarboxylate and polyethylene succinate of the...

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Abstract

The invention provides an artificial skin as well as a preparation mthod thereof, which solves the technical problems of the existing artificial skin after the skin grafting that the artificial skin antibacterial function is poor in lasting effectiveness or the artificial skin is orderlessly degraded in chaos, resulting in failure of the skin grafting. The artificial skin is a double-layer structure consisting of a protective film layer, a compact film layer and filling compounds, wherein the protective film layer is connected to the upper surface of the compact film layer in a smearing manner, the compact film layer is a porous film structure, netted pores are arranged in the compact film layer along a three-dimensional direction, and the pores are respectively fully filled with the filling compounds; the protective film layer is artemisia argyi extract, the compact film layer is prepared by mixing, melting, depositing and molding polycarboxylic anhydride and polyethylene glycol succinate, and the filling compounds consist of collagen, polylysine, glycine, Arabic gum, citric acid, and Chinese herb extract with an antibacterial and antivirus effect. The invention also provides a preparation method of the artificial skin, which can be widely applied to the technical field of medical aid.

Description

technical field [0001] The invention relates to the technical field of medical assistance, in particular to an artificial skin and a preparation method thereof. Background technique [0002] The skin is the largest organ of the human body. It not only has the function of resisting external environmental infections, but also undertakes the task of preventing the loss of water, electrolytes and other substances in the body. Under normal circumstances, if the skin is slightly damaged, it can recover by itself. When a large area of ​​skin is severely burned or damaged, the doctor must immediately infuse fluids and protect the wound. If only the superficial layer of the skin is damaged, the new skin will regeneration. If a patient has suffered a severe burn and the skin cannot repair itself, superficial skin from another part of the body is usually grafted over the wound, but this method can cause new scars. Moreover, if it is a large area of ​​burns, there will be very little ...

Claims

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Application Information

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IPC IPC(8): A61L27/60A61L27/54A61L27/40
CPCA61L27/18A61L27/20A61L27/24A61L27/3637A61L27/54A61L27/60A61L2300/30A61L2300/404C08L77/04C08L67/04C08L5/00
Inventor 张鹏刘康王传杰孙金平陈刚
Owner HARBIN INST OF TECH AT WEIHAI
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