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Application of inosine in prevention and treatment of depression

A depression and inosine technology, applied in the field of medicine, can solve problems such as inosine prevention or treatment of depression.

Inactive Publication Date: 2018-11-30
SICHUAN CREDIT PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on the prevention or treatment of depression by inosine

Method used

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  • Application of inosine in prevention and treatment of depression
  • Application of inosine in prevention and treatment of depression
  • Application of inosine in prevention and treatment of depression

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1 The experiment that inosine of the present invention prevents depression

[0023] 1. Preparation of experimental animals

[0024] 35-40g healthy male Crl:CD1 mice (provided by Experimental Animal Center of Chongqing Medical University) were selected. The temperature of the feeding environment is 23±1°C, the humidity is 50±5%, and the light / dark cycle is 12 hours / 12 hours (lighting time is 08:00-20:00). During the sugar water test period, only food and water are available. Before the formal experiment, a period of 2 weeks of environmental adaptation was carried out.

[0025] 2. Preparation of experimental reagents and experimental materials

[0026] Experimental reagents:

[0027] ① Lipopolysaccharide (Lipopolysaccharide, LPS, Escherichia coli serotype 0127:B8, from Sigma, USA). Dissolved in sterile normal saline, 30 minutes after inosine injection, intraperitoneal injection, the injection dose is 0.83mg / kg.

[0028] ② Inosine (Inosine, from Sigma, USA)...

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PUM

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Abstract

The invention discloses application of inosine in preparation of drugs for treatment and / or prevention of depression. Animal experiments prove that inosine has the significant effect of reversing depression-like behaviors, therefore inosine can be used for prevention and treatment of depression, and provides a new method and means for clinical treatment of depression.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to the application of inosine in preventing depression. Background technique [0002] Depression is a heterogeneous major mental illness caused by multiple factors, with significant and persistent low mood as the main clinical feature. Its morbidity and mortality are high. According to the World Health Organization, the global annual incidence of depressive disorder is about 6%, and the lifetime prevalence is about 16%. There are about 350 million depressed patients in the world. The prevalence of depression in my country is about 6.87%, that is, about 90 million people are affected. Long-term persistent depressive symptoms can lead to severe cognitive impairment, which brings a heavy burden of disease to patients, families and society. 50% to 60% of patients with depression are accompanied by suicidal tendencies, and 15% to 20% of patients eventually commit suicide. According ...

Claims

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Application Information

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IPC IPC(8): A61K31/7076A61P25/24
CPCA61K9/0019A61K31/7076A61P25/24
Inventor 谢鹏刘兰香李雯雯周婵娟王海洋
Owner SICHUAN CREDIT PHARMA
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