Composite skin antiseptic solution composition and preparation method thereof

A skin disinfection and composition technology, which is applied in the directions of iodine compound active ingredients, artificially synthesized polymeric material active ingredients, drug delivery, etc., can solve the problems of low content, poor sterilization and disinfection performance, etc., and achieves broad antibacterial spectrum and good bactericidal effect. , the effect of a broad spectrum of sterilization

Pending Publication Date: 2018-11-30
郑州吉尔康消毒制品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The content of polyhexamethylene guanidine and polyvinylpyrrolidone-iodine in the above-mentioned disinfectants is relatively low, and the sterilization and disinfection performance is relatively poor

Method used

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  • Composite skin antiseptic solution composition and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The composite skin disinfectant composition of the present embodiment is made up of each component of following mass percentage:

[0031] Povidone-iodine 2%, guanidine disinfectant 0.8%, ethanol 62.4%, wetting agent 0.1%, pH regulator 0.8%, and the balance is water.

[0032] The guanidine disinfectant is chlorhexidine gluconate.

[0033] Ethanol is edible ethanol with a volume fraction of 95%.

[0034] The wetting agent is a mixture of polyethylene glycol and fatty alcohol polyoxyethylene ether. The mass ratio of polyethylene glycol to fatty alcohol polyoxyethylene ether is 1:3. The average molecular weight of polyethylene glycol is 400.

[0035] The pH regulator is citric acid. Citric acid is food-grade citric acid with a purity of 99%.

[0036] The preparation method of the composite skin disinfectant composition of the present embodiment may further comprise the steps:

[0037] 1) dissolving the povidone-iodine of formula quantity in the water of formula quanti...

Embodiment 2

[0042] The composite skin disinfectant composition of the present embodiment is made up of each component of following mass percentage:

[0043] Povidone-iodine 3%, guanidine disinfectant 0.8%, ethanol 52.1%, wetting agent 1%, pH regulator 1.5%, and the balance is water.

[0044] The guanidine disinfectant is chlorhexidine acetate.

[0045] Ethanol is edible ethanol with a volume fraction of 95%.

[0046] The wetting agent is a mixture of polyethylene glycol and polyvinylpyrrolidone. The mass ratio of polyethylene glycol to polyvinylpyrrolidone is 4:1. The average molecular weight of polyethylene glycol is 400.

[0047] The pH regulator is citric acid. Citric acid is food-grade citric acid with a purity of 99%.

[0048] The preparation method of the composite skin disinfectant composition of the present embodiment may further comprise the steps:

[0049] 1) dissolving the povidone-iodine of formula quantity in the water of formula quantity, obtains the aqueous solution o...

Embodiment 3

[0054] The composite skin disinfectant composition of the present embodiment is made up of each component of following mass percentage:

[0055] Povidone-iodine 5%, guanidine disinfectant 0.1%, ethanol 42.4%, wetting agent 1.5%, pH regulator 0.01%, and the balance is water.

[0056] The guanidine disinfectant is chlorhexidine gluconate.

[0057] Ethanol is edible ethanol with a volume fraction of 95%.

[0058] The wetting agent is a mixture of polyethylene glycol and fatty alcohol polyoxyethylene ether. The mass ratio of polyethylene glycol to fatty alcohol polyoxyethylene ether is 1:2.5. The average molecular weight of polyethylene glycol is 400.

[0059] The pH regulator is hydrochloric acid. The mass concentration of hydrochloric acid is 36%.

[0060] The preparation method of the composite skin disinfectant composition of the present embodiment may further comprise the steps:

[0061] 1) dissolving the povidone-iodine of formula quantity in the water of formula quant...

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Abstract

The invention relates to a composite skin antiseptic solution composition and a preparation method thereof, which belong to the technical field of the skin antiseptic solution. The composite skin antiseptic solution composition comprises the following components by mass percentage: 2-5% of povidone-iodine, 0.1-0.8% of a guanidine disinfectant, 42.4-73.5% of ethanol, 0.1-2.0% of a wetting agent, 0.01-1.5% of a pH conditioning agent, and the balance of water. The composite skin antiseptic solution composition has the characteristics of low toxicity, less irritation, wide antimicrobial spectrum,stable physical and chemical performance, moderate viscosity, easy dissolution in water, no yellow staining, and low cost.

Description

technical field [0001] The invention belongs to the technical field of disinfectants, and in particular relates to a composite skin disinfectant composition and a preparation method thereof. Background technique [0002] Skin disinfectants refer to disinfection products used on skin, mucous membranes, wounds, burn wounds and other parts for the purpose of preventing and controlling bacterial infection. Skin disinfectants can destroy the physiological functions of pathogens and cause them to die by changing the enzyme system, protein and physiological activities of pathogens. Skin disinfectants mainly include iodine, alcohols, phenols, peroxides, guanidines, quaternary ammonium salts, and acidic oxidation potential water. [0003] Iodine-based disinfectants mainly include iodine tincture, iodophor, and povidone-iodine. Povidone-iodine is an amorphous complex of elemental iodine and polyvinylpyrrolidone. Povidone-iodine can change the wettability of the solution to the skin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/18A61K31/79A61K31/155A61K9/08A61K47/10A61P31/02
CPCA61K47/10A61P31/02A61K9/0014A61K9/08A61K31/155A61K31/79A61K33/18A61K2300/00
Inventor 邝金瑞王秋艳张果
Owner 郑州吉尔康消毒制品有限公司
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