A class of dyes with strong absorption and photothermal effect in near-infrared region and its preparation method and application
A near-infrared region, photothermal effect technology, applied to medical preparations containing active ingredients, organic dyes, chemical instruments and methods, etc., can solve problems such as poor photostability, poor biocompatibility, and low photothermal conversion efficiency. Achieve the effect of significant application prospects
Inactive Publication Date: 2019-12-06
DALIAN UNIV OF TECH
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AI Technical Summary
Problems solved by technology
Commonly used near-infrared photothermal sensitizers include indocyanine green (ICG), carbon nanotubes and gold nanorods, etc., but ICG has the disadvantages of poor photostability and low photothermal conversion efficiency. There is a disadvantage of poor biocompatibility, therefore, it is necessary to develop a class of dye molecules with strong absorption and photothermal effect in the first and second near-infrared regions to avoid the above disadvantages
Method used
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Embodiment 1
[0032]
[0033] Oxonium salt W1 (0.2mmol), condensing agent S1 (0.09mmol), and sodium acetate (0.2mmol) were mixed evenly, then 5mL of acetic anhydride was added, reacted at 140°C for 120min, and the progress was checked by spotting. The product was purified by column separation, HRMS (M + ): 521.3160.
Embodiment 2
[0035]
[0036] Onium salt W2 (0.2mmol), condensing agent S1 (0.09mmol), and sodium acetate (0.2mmol) were mixed evenly, then 5mL of acetic anhydride was added, reacted at 140°C for 120min, and the progress was checked by spotting. The product was purified by column separation, HRMS (M + ): 493.2850.
Embodiment 3
[0038]
[0039] Onium salt W3 (0.2mmol), condensing agent S1 (0.09mmol), and sodium acetate (0.2mmol) were mixed evenly, then 5mL of acetic anhydride was added, reacted at 140°C for 120min, and the progress was checked by spotting. The product was purified by column separation, HRMS (M + ): 549.3476.
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The invention discloses dye with strong absorption and photothermal effects in near infrared regions as well as a preparation method and an application of the dye and belongs to the technical field offine chemistry. Compared with conventional cyanine dye, the dye has longer wavelength, has absorption in first and second near infrared regions, can overcome various defects in a visible region during imaging and can be used for performing various optical imaging of the first and second near infrared regions; the dye can also be used for optical therapy of the first and second near infrared regions due to strong absorption in the near infrared regions.
Description
technical field [0001] The invention relates to a class of long-wavelength dyes with strong absorption and photothermal effects in the first and second near-infrared regions and a preparation method and application thereof, belonging to the technical field of fine chemicals. Background technique [0002] The development of fluorescence microscopy and fluorescent dyes has shortened the distance between people and the microscopic cellular world. With the advantage of fluorescence visualization, a large number of excellent fluorescent dyes and probes have been developed, many of which have been commercialized. The absorption and emission wavelengths of traditional fluorescent dyes are in the visible region, and there are relatively few commercial dyes and kits that reach the near-infrared region. Although the commercially available fluorescent dyes can meet some basic needs, they also have some problems. For example, cells have a strong ability to absorb and scatter fluorescenc...
Claims
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IPC IPC(8): C09B23/04C09B23/06C09B23/10A61K41/00A61P35/00
CPCA61K41/0052A61P35/00C09B23/04C09B23/06C09B23/105
Inventor 肖义边辉陈令成张新富
Owner DALIAN UNIV OF TECH