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Application of integrating ginkgo biloba leaf extract and donepezil to preparation of drug for controlling Alzheimer's disease

A technology of ginkgo ketone ester and donepezil, applied in the field of application in the preparation of drugs for preventing and treating Alzheimer's disease

Inactive Publication Date: 2018-12-18
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinically, there is no report on the optimal dose-effect relationship and compatibility ratio of ginkgosterone ester and donepezil combination

Method used

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  • Application of integrating ginkgo biloba leaf extract and donepezil to preparation of drug for controlling Alzheimer's disease
  • Application of integrating ginkgo biloba leaf extract and donepezil to preparation of drug for controlling Alzheimer's disease
  • Application of integrating ginkgo biloba leaf extract and donepezil to preparation of drug for controlling Alzheimer's disease

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] 1 Experimental materials

[0023] 1.1 Experimental drugs

[0024] Ginkgo Ketone Ester Dispersible Tablets (Guoyao Zhunzi Z20050670) were purchased from Jiangsu Shenlong Pharmaceutical Co., Ltd.; donepezil hydrochloride (approval number: Guoyao Zhunzi H20070181) was purchased from Eisai (China) Pharmaceutical Co., Ltd.

[0025] 1.2 Experimental animals

[0026] SPF grade male ICR mice, weighing 18-22 g, were purchased from Qinglongshan Animal Breeding Farm, Jiangning District, Nanjing, certificate number: SCXK (Su) 2017-0001. All the mice were randomly divided into cages, and the indoor temperature was 22 ± 2 ° C, the relative humidity was 50 ± 5%, and 12 hours of light were provided with alternating light and dark. The mice in each cage were allowed to eat and drink freely. The experimental protocol was approved by the Animal Experiment Ethics Committee of Nanjing University of Traditional Chinese Medicine, and all procedures were performed in strict accordance with ...

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Abstract

The invention discloses application of integrating ginkgo biloba leaf extract and donepezil to preparation of a drug for controlling Alzheimer's disease. Through a great number of experiments for screening, a comprehensive multi-index comprehensive index method and PCA are adopted for comparing ginkgo biloba leaf extract and donepezil single-use value with a ginkgo biloba extract-donepezil total effect value, so that the two medicines have a dose-effect relationship when the integrated dose is 0.5-1 time of that of clinical dose, and the treatment effect is optimal when the dose of the two medicines is one time of the clinical dose; when the dose is 2-6 times of that of the clinical dose, the treatment effect is weaker than that of the clinical dose, and is obviously superior to that of single-use dose of the two medicines; when the dose is further increased to be 8-10 times of the dose, the treatment effect is inferior to that of single-use treatment effect of the two medicines. On the basis of the optional best dose, the total effect of ginkgo biloba leaf extract and donepezil in different weight proportions is further evaluated, and the weight of the two medicines is found to begreater in proportion of ginkgo biloba leaf extract or donepezil, so that the total effect is in downtrend. According to the research results, the Alzheimer's disease prevention effect is optimal when the weight proportion of the inkgo biloba extract to donepezil is (1 to 1)-(1 to 3), so that very good synergistic interaction is achieved.

Description

technical field [0001] The invention belongs to a pharmaceutical composition, specifically relates to the application of ginkgo ketone ester and donepezil in combination in the preparation of drugs for preventing and treating Alzheimer's disease, and belongs to the technical field of drugs. Background technique [0002] Alzheimer's disease (AD), i.e. senile dementia, is the most common disease among the elderly. With the aging of the global population, the prevalence of Alzheimer's disease is increasing year by year. The clinical symptoms are generally characterized by progressive memory loss and loss of acquired knowledge, until the loss of daily activity ability, which brings a heavy burden to the society and family and becomes a serious social and medical health problem. The etiology of AD is not clear, and it is generally believed that it is related to factors such as heredity, biochemistry, neuroendocrine, immunity and environment on the basis of aging. In addition, o...

Claims

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Application Information

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IPC IPC(8): A61K31/445A61K31/365A61P25/28
CPCA61K31/365A61K31/445A61P25/28A61K2300/00
Inventor 周桂生张静唐于平段金廒
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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