Drug-loaded magnetic microbubble, and preparation method and application thereof

A drug-carrying and magnetic technology, applied in pharmaceutical formulations, drug combinations, and non-active ingredients medical preparations, etc., can solve the problems of insufficient clinical translation prospects, complex and tedious preparation processes, and low targeting ability, and achieve high clinical applications. Prospect, good biosafety, low side effects

Active Publication Date: 2018-12-21
NANJING UNIV OF POSTS & TELECOMM
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

However, the existing technology still has defects: weak protection ability, low targeting ability, low thrombolytic efficiency, complicated and cumbersome preparation process, and insufficient prospects for clinical transformation

Method used

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  • Drug-loaded magnetic microbubble, and preparation method and application thereof
  • Drug-loaded magnetic microbubble, and preparation method and application thereof
  • Drug-loaded magnetic microbubble, and preparation method and application thereof

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Embodiment Construction

[0033] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the examples. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0034] The application principle of the present invention will be described in detail below in conjunction with the accompanying drawings.

[0035] The present invention prepares drug-loaded magnetic microbubbles by utilizing iron ferric oxide nanoparticles and drug-loaded silica nanoparticles to self-assemble at the gas-liquid interface and tightly wrapping the air core wrapped by the surfactant. In the following examples, sodium lauryl sulfate was used as a surfactant, and tissue plasminogen activator was used as a drug to be loaded to prepare a drug for treating venous thrombosis.

[0036] 1. Preparation of drug-loaded mag...

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Abstract

The invention discloses a drug-loaded magnetic microbubble, and a preparation method and application thereof. A drug-loaded nanometer particle packaged magnetic microbubble is formed by loading drug into mesoporous silica particles and self-assembling drug-loaded silicon dioxide nanometer particles and magnetic nanometer particles in a gas-liquid interface formed through a homogenizer in ice-bathenvironment. The drug-loaded magnetic microbubble is applied to drugs for treating phlebothrombosis, not only can protect thrombolytic drug, but also has rapid response, magnetic targeted enrichment and drug ultrasonic release, can increase the thrombolysis speed, and can solve low drug efficiency, toxic and side effect and bleeding complications in clinic thrombus treatment.

Description

technical field [0001] The invention belongs to the technical field of micro-nano drug loading, and in particular relates to a drug-loading magnetic microbubble and its preparation method and application. Background technique [0002] Abnormal blood flow in blood vessels caused by vascular occlusion seriously threatens human health. Unhealthy living patterns, poor eating habits, harsh environmental factors, congenital genetic factors, or other physiological diseases (diabetes, tumors, tissue damage) are all very easy to form blood vessel blockage in different organs or parts of the human body, causing various Diseases such as: coronary artery disease (heart), stroke (brain tissue), renovascular disease (kidneys), and peripheral vascular disease (limbs). According to the latest statistics, the disease caused by vascular obstruction has become the leading cause of death and disease in the world; 1 out of every 3 deaths is due to cardiovascular disease; in China, the death tol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/49A61K47/04A61P7/02
CPCA61K38/49A61K47/02A61P7/02
Inventor 高宇汪联辉王思雨郭西西肖华新陈付斌
Owner NANJING UNIV OF POSTS & TELECOMM
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