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Compositions and methods for treating paranasal mucosa diseases with nicotinic acetylcholine receptor agonists

一种组合物、激动剂的技术，应用在治疗、光疗法、放射疗法等方向，能够解决没有提供解决方案来缓解或治疗鼻塞、肾上腺皮质激素不良副作用妨碍广泛使用等问题

Pending Publication Date: 2018-12-21
A 索利斯 赫雷拉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, adverse side effects of corticosteroids may prevent their widespread use
[0014] None of these prior art methods, medicaments, treatments and / or therapies provide a fully satisfactory solution to relieve or treat symptoms or underlying causes of nasal congestion, nasal allergies, allergic rhinitis, and other conditions of the nose and paranasal mucosa

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0079] Example 1: Treatment of Patients Suffering from Chronic Nasal Congestion

[0080] A 31-year-old female patient had chronic nasal congestion for the past 10 years. Previous treatment by multiple physicians had had poor results, including previous treatment with topical and systemic vasoconstrictors and antibiotics. Initial examination of the patient revealed that her nasal mucosa exhibited moderate edema. The right inferior turbinate was slightly enlarged and inflamed. The patient also complained of frequent headaches in the frontal area.

[0081] Treatment of the patient was initiated with an aqueous solution containing (S)-(1-methyl-2-pyrrolidinyl)-pyridine at a concentration of 1.00 mg / ml and salicylic acid at a concentration of 0.5 mg / ml, instilled into each nostril Two drops (about 50 μL each), and inhaled. This dosage is repeated three or four times daily. At a follow-up one month later, the patient reported a 90% improvement in her symptoms, 100% of which was...

Embodiment 2

[0082] Example 2: Treatment of a patient with a history of epistaxis and dryness

[0083] A 68-year-old woman presented with a history of minor epistaxis and dryness of the nose and eyes. The patient also reported a long history of joint pain without other significant antecedents. The patient presented with nasal mucosal atrophy on examination, which was determined not to be recent.

[0084] Initiate treatment of the patient with an aqueous solution containing (S)-(1-methyl-2-pyrrolidinyl)-pyridine at a concentration of 2.0 mg / ml and salicylic acid at a concentration of 0.5 mg / ml in a dose of one to two drops (about 50 μL per drop), and then forcibly inhaled. This dose is repeated three to four times daily. At a follow-up visit one month later, the patient reported that the epistaxis had stopped and that the dryness of the nose and eyes had significantly decreased since the first week of treatment. Clinicians recommend continued treatment with (S)-(1-methyl-2-pyrrolidinyl)...

Embodiment approach 1

[0087] Embodiment 1 is a method of treating or preventing a nasal or paranasal mucosal disorder in a subject, the method comprising administering to the subject's nose or paranasal mucosa a therapeutically effective amount of a pharmaceutical composition, the pharmaceutical composition A nicotinic acetylcholine receptor (nAChR) agonist and at least one pharmaceutically acceptable diluent, excipient or carrier are included.

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PUM

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Abstract

Methods of treating and preventing conditions of a nasal or paranasal mucous membrane are described. The methods include administering a pharmaceutical composition including a nicotinic acetylcholinereceptor (nAChR) agonist, such as (S)-(l-methyl-2- pyrrolidinyl)-pyridine, or a pharmaceutically acceptable salt, analog, precursor or derivative thereof. The methods can be used to treat a wide variety of conditions of the nasal or paranasal mucous membrane, such as nasal congestion and nose bleeds.

Description

[0001] Cross References to Related Applications [0002] Pursuant to 35 U.S.C. §119(d), this application claims priority to Australian Provisional Patent Application No. 2016901359, filed April 12, 2016, the disclosure of which is incorporated herein by reference in its entirety. field of invention [0003] The present invention relates to methods and compositions for the treatment and prevention of nasal and paranasal mucosal disorders. Background technique [0004] The nose is a complex organ related to the respiratory tract and central nervous system. The nose has a single nasal cavity that opens to the face at the anterior nostrils (nostrils) and extends back into the pharynx. The inner surface area of ​​the nose is increased due to the presence of multiple turbinates, structures on the medial nasal wall whose cross-section shows a thin tear-like shape hanging within the nasal cavity. The turbinates include the superior, middle, and inferior turbinates. The nasal cavi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06C07D453/02A61K31/439
CPCA61K45/06A61K9/0043A61K9/08A61K47/38A61P11/02A61K31/465A61K2300/00A61K31/4439A61K31/60A61K9/12A61K47/12A61N5/0603A61N2005/0607
Inventor A·索利斯·赫雷拉
Owner A 索利斯 赫雷拉
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