A kind of lung cancer marker anti-mmp12 autoantibody and its application

One-MMP12, MMP12 technology, applied in the field of lung cancer marker anti-MMP12 autoantibody, can solve the problem of unsatisfactory tumor markers, and achieve the effect of low cost, high accuracy and simple operation

Active Publication Date: 2021-06-04
THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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Problems solved by technology

[0006] The purpose of the present invention is to overcome the problem of unsatisfactory existing tumor markers of lung cancer, aiming at improving the sensitivity, specificity and accuracy of early diagnosis of lung cancer

Method used

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  • A kind of lung cancer marker anti-mmp12 autoantibody and its application
  • A kind of lung cancer marker anti-mmp12 autoantibody and its application
  • A kind of lung cancer marker anti-mmp12 autoantibody and its application

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Embodiment Construction

[0020] Such as figure 1 As shown, the present invention uses the Oncomine database to screen lung cancer-related tumor antigens, and uses the ELISA method to detect the level of anti-MMP12 antibody in the serum of lung cancer patients, and finally uses the ELISA method to verify the detection value of anti-MMP12 for lung cancer.

[0021] 1) Use the Oncomine database to mine abnormally expressed genes in lung cancer tissues, and screen out genes whose mRNA expression in non-small cell lung cancer tissues is significantly higher than that in normal lung tissues, suggesting that they may be candidate biomarkers for lung cancer detection.

[0022] 2) In order to further verify whether anti-MMP12 autoantibody can be used as a diagnostic marker for lung cancer, ELISA detection method was used to detect the level of anti-MMP12 autoantibody in the serum of 184 cases of lung cancer patients and 184 cases of normal people. The steps include: using Antigen Diluent Dilute the purified MMP...

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Abstract

The invention belongs to the technical field of biomedical detection, and specifically relates to a lung cancer marker anti-MMP12 autoantibody and its application. The invention discloses a lung cancer marker, and the lung cancer marker is an anti-MMP12 autoantibody. The present invention also provides the application of the above-mentioned lung cancer markers in the preparation of a lung cancer detection kit. The present invention aims to provide a clinically applicable lung cancer marker with simple operation, low cost, high accuracy and non-invasiveness and a reagent kit for preparing the marker for lung cancer evaluation. The present invention finds that the application of ELISA method to detect serum anti-MMP12 autoantibodies can more accurately distinguish lung cancer patients from normal people, as well as patients with benign lung disease groups (COPD and chronic bronchitis), and can be used for the diagnosis of lung cancer. early detection. In this context, the convenient, fast and effective marker for detecting lung cancer patients and the reagent kit for preparing the marker for lung cancer detection are provided, which can be used for clinical early diagnosis of lung cancer.

Description

technical field [0001] The invention belongs to the technical field of biomedical detection, and specifically relates to a lung cancer marker anti-MMP12 autoantibody and application thereof. Background technique [0002] Lung cancer is a malignant tumor with the highest morbidity and mortality in China and the world. In the past 40 years, the 5-year survival rate of lung cancer has only increased from 12% to 16%. The main reason is that it is diagnosed at an advanced stage. On the contrary, the survival rate of lung cancer diagnosed at an early stage can be increased to 80% after surgery. It can be seen that early detection and early diagnosis have important clinical significance for the treatment and prognosis of lung cancer. Currently widely used detection methods include non-invasive examinations (such as X-ray, CT, mammography, etc.) possibility of widespread use. Finding new lung cancer molecular markers, especially serum molecular markers, so that lung cancer patien...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/574
CPCG01N33/57484
Inventor 刘蔚代丽萍陈奎生王进
Owner THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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