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Anti-blood stasis syndrome application of scirpusin component C in common burreed rhizome

A technology of blood stasis syndrome and trilens, which is applied in the field of medicine, can solve the problem that the active ingredients of sanlens are not clear enough

Active Publication Date: 2019-01-11
GUANGDONG PHARMA UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved in the present invention is to overcome the defects and deficiencies of the existing three-lens active ingredients that are not clear enough, and prove for the first time that three-lens A and three-lens C have the medicinal effect of anti-blood stasis

Method used

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  • Anti-blood stasis syndrome application of scirpusin component C in common burreed rhizome
  • Anti-blood stasis syndrome application of scirpusin component C in common burreed rhizome
  • Anti-blood stasis syndrome application of scirpusin component C in common burreed rhizome

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Experimental program
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Effect test

Embodiment 1

[0025] Example 1 compound blood circulation promoting function experiment

[0026] 1. Experimental materials

[0027] (1) Drugs: Trilens A, Trisensin B and Trisensin C were self-made in the experiment, with a purity of ≥99%.

[0028] (2) Animal: KM mouse, ♀, body weight 25±5g, provided by Guangdong Experimental Animal Center, license number: SCK (Guangdong) 2013-0002.

[0029] (3) Reagents

[0030] Epinephrine Hydrochloride Injection (Grand Medicine (China) Co., Ltd., batch number: 20170214); Bayer Aspirin Enteric-Coated Tablets (Bayer Healthcare Co., Ltd., batch number: BJ32400); Carboxymethylcellulose Sodium (CMC-Na, Sinopharm Chemicals Reagent Co., Ltd., batch number: F20110915, analytically pure); sodium chloride (Tianjin Zhiyuan Chemical Reagent Co., Ltd., batch number: 20160312, analytically pure); mouse thromboxane B2 (TXB2), endothelin 1 (ET-1), Plasminogen activator inhibitor 1 (PAI-1), fibrinogen (FIB) enzyme-linked immunoassay kit (Tianjin Anoricang Biotechnology...

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Abstract

The invention discloses application of a scirpusin component C in common burreed rhizome in synthesis of anti-blood stasis syndrome drugs. The invention first proves that the scirpusin C has an obvious anti-blood stasis drug effect, and can be used for preparing a medicine for treating the blood stasis syndrome. Pharmacological experiments prove that the scirpusin C is capable of obviously reducing the levels of thromboxane B2 (TXB2), fibrinogen (FIB), active plasminogen activator inhibitor (PAI-1) and endothelin 1 (ET-1) in serum of blood stasis model mice and improving the thymus index (TI),spleen index (SI) and hepatic index (HI) of the mice, and has high clinical application value and development prospects in the aspect of treating the blood stasis syndrome.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the anti-blood stasis application of a trigonin component (trigenin C). Background technique [0002] Sanleng is the dry tuber of Sparganium stoloni erum Buch.-Ham., a plant of the family Black Trigonaceae, which has been recorded in previous "Chinese Pharmacopoeia". Qi, eliminating stagnation and relieving pain. Sanleng can be used alone in raw products and vinegar products, and can also be combined with curcuma and astragalus to enhance the curative effect. It is mainly used in the treatment of endometriosis, uterine fibroids and other gynecological diseases, as well as liver diseases and cardiovascular and cerebrovascular diseases. and other diseases. [0003] The chemical composition of Sanleng is complex, containing flavonoids, volatile oils, phenylpropanoids, organic acids, alkaloids, anthraquinones, steroids and polypeptides. Modern pharmacological research has clarifi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/495A61P7/02
CPCA61K31/495A61P7/02
Inventor 梁生旺冀苏龙王淑美许晓丽
Owner GUANGDONG PHARMA UNIV
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