Unlock instant, AI-driven research and patent intelligence for your innovation.

A Protein Structure Prediction Method Based on Specific Fragment Crossovers

A protein structure and prediction method technology, applied in the fields of computer applications, bioinformatics, and intelligent information processing, can solve problems such as low prediction accuracy and low conformational search ability, and achieve the effects of strong search ability, improved precision, and improved accuracy

Active Publication Date: 2021-08-03
ZHEJIANG UNIV OF TECH
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to overcome the defects of low conformation search ability and low prediction accuracy of existing protein structure prediction methods, the present invention provides a protein structure prediction method based on specific fragment crossover with high conformation search ability and high prediction accuracy

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A Protein Structure Prediction Method Based on Specific Fragment Crossovers
  • A Protein Structure Prediction Method Based on Specific Fragment Crossovers
  • A Protein Structure Prediction Method Based on Specific Fragment Crossovers

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0034] The present invention will be further described below in conjunction with the accompanying drawings.

[0035] refer to figure 1 and figure 2 , a protein structure prediction method based on specific fragment crossovers, comprising the following steps:

[0036] 1) Input the query sequence, and use Psipred (http: / / bioinf.cs.ucl.ac.uk / psipred / ) to predict the secondary structure information of the query sequence;

[0037]2) Set the population size NP, the maximum number of iterations G, the crossover probability CR, the number of mutation failures M, the maximum number of mutations allowed N, the Boltzmann temperature factor KT, the input fragment library, the predicted secondary structure information, and the number of iterations g = 0;

[0038] 3) Initialize all conformations of the population, and assemble fragments for each conformation in the population until the dihedral angle of each residue in the conformation has been replaced at least once;

[0039] 4) Confo...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A protein structure prediction method based on specific fragment crossover, including the following steps: firstly predict the secondary structure information of the query sequence, and construct a fragment library; secondly, design a strategy based on specific fragment crossover, establish a fitness function for the secondary structure information, and design Crossover mutation strategy; finally, the population is updated according to the proportional fitness distribution method, and the strategy based on the design of specific fragment crossover can effectively improve the algorithm's conformational search ability and prediction accuracy, and the predicted tertiary structure has a good secondary structure. The invention provides a protein structure prediction method with high conformation search capability and high prediction accuracy.

Description

technical field [0001] The invention relates to the field of bioinformatics, intelligent information processing, computer application, and protein structure prediction, in particular to a protein structure prediction method based on specific segment crossover. Background technique [0002] Protein is an important part of life and the bearer of life activities. The basic unit of protein is amino acid. There are more than 20 common amino acids in nature. Amino acids are composed of central carbon atoms and connected amino groups, carboxyl groups, hydrogen atoms and side chains of amino acids. Amino acids are dehydrated and condensed to form peptide bonds. Amino acids linked by peptide bonds form a long chain called a protein. [0003] Protein molecules play a vital role in the process of biological and cellular chemical reactions. Their structural models and bioactive states have important implications for our understanding and cure of many diseases. Only when proteins are ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): G16B15/00G16B15/20
Inventor 张贵军马来发王小奇周晓根胡俊
Owner ZHEJIANG UNIV OF TECH