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Bleeding-stopping healing-promoting foam dressing, and preparation method and application thereof

A foam and foam stabilizer technology, applied in the field of medicine, can solve the problems of high temperature and other conditions, failure to meet the use requirements, inconvenient use process, etc., to achieve the effect of simple process, excellent healing effect, and avoid irritation

Active Publication Date: 2019-01-29
GUANGZHOU RAINHOME PHARM&TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, liquid dressings are usually in a liquid state, have poor stability, and are inconvenient to use. The preparation method has high requirements on conditions such as temperature, which cannot meet people's use requirements.

Method used

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  • Bleeding-stopping healing-promoting foam dressing, and preparation method and application thereof
  • Bleeding-stopping healing-promoting foam dressing, and preparation method and application thereof
  • Bleeding-stopping healing-promoting foam dressing, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] The foam dressing is prepared from the following raw materials in parts by weight:

[0040] 25 parts of chitosan, 15 parts of frankincense, 15 parts of oligomeric L-lactic acid, 12 parts of Dendrobium nobile extract, 3 parts of sodium lauryl sulfate, 3 parts of sodium dodecylbenzenesulfonate, 4 parts of silicone oil, 1 part of stannous octoate, 1 part of dibutyltin, 1 part of triethanolamine, 1 part of tetrahydrofuran, 1 part of petroleum ether, 1 part of trichlorofluoromethane, 2 parts of silicone foam stabilizer, 100 parts of water;

[0041] Preparation:

[0042] (1) Mix chitosan, frankincense, oligomeric L-lactic acid and water, and stir for 5 minutes at 25°C;

[0043] (2) Add sodium lauryl sulfate, sodium dodecylbenzenesulfonate, silicone oil, stannous octoate, dibutyltin, triethanolamine, tetrahydrofuran, petroleum ether, trichlorofluoromethane and silicone foam stabilizer, place In the foaming mold, keep warm at 60°C for 15 minutes, demold and cut;

[0044] (3)...

Embodiment 2

[0046] The foam dressing is prepared from the following raw materials in parts by weight:

[0047] 20 parts of chitosan, 25 parts of frankincense, 10 parts of oligomeric L-lactic acid, 15 parts of Dendrobium nobile extract, 3 parts of sodium lauryl sulfate, 3 parts of sodium dodecylbenzenesulfonate, 4 parts of silicone oil, 1 part of stannous octoate, 1 part of dibutyltin, 1 part of triethanolamine, 1 part of triethylenediamine, 1 part of triethylamine, 1 part of tetrahydrofuran, 5 parts of silicone foam stabilizer, 100 parts of water;

[0048] Preparation:

[0049] (1) Mix chitosan, frankincense, oligomeric L-lactic acid and water, and stir for 10 minutes at 20°C;

[0050](2) Add sodium dodecylsulfate, sodium dodecylbenzenesulfonate, silicone oil, stannous octoate, dibutyltin, triethanolamine, triethylenediamine, triethylamine, tetrahydrofuran and silicone foam stabilizer, set In the foaming mold, keep warm at 55°C for 20 minutes, demold and cut;

[0051] (3) Soak in the e...

Embodiment 3

[0053] The foam dressing is prepared from the following raw materials in parts by weight:

[0054] 30 parts of chitosan, 5 parts of frankincense, 20 parts of oligomeric L-lactic acid, 10 parts of Dendrobium nobile extract, 10 parts of stearic acid, 10 parts of lecithin, 1 part of stannous octoate, 1 part of tetrahydrofuran, 1 part of petroleum ether 1 part, 1 part of trichlorofluoromethane, 2 parts of dichlorotetrafluoroethane, 1 part of silicone foam stabilizer, 200 parts of water;

[0055] Preparation:

[0056] (1) Mix chitosan, frankincense, oligomeric L-lactic acid and water, and stir for 1 min at 30°C;

[0057] (2) Add stearic acid, lecithin, stannous octoate, tetrahydrofuran, petroleum ether, trichlorofluoromethane, dichlorotetrafluoroethane and silicone foam stabilizer, place in a foaming mold, and keep warm at 65°C 10min, demoulding and cutting;

[0058] (3) Soak in the extract of Dendrobium nobile at 70° C. for 40 minutes, and dry to obtain the foam dressing.

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Abstract

The invention provides a bleeding-stopping healing-promoting foam dressing, and a preparation method and application thereof. The method comprises the following steps: (1) mixing and stirring chitosan, frankincense, L-lactic acid oligomer and water; (2) adding a surfactant, a catalyst, a foaming agent and a foam stabilizer, placing the obtained mixture in a foaming mold, and conducting heat preservation, demolding and cutting; (3) conducting immersing in a harba dendrolii nobilis extraction solution, and conducting drying to obtain the foam dressing. The foam dressing prepared by the method ofthe invention adopts an immersing way of immersing in the harba dendrolii nobilis extraction solution, and is simple in process, thus harba dendrolii nobilis is adsorbed for increasing the medicinaleffect of the foam dressing, and also the irritating property of the traditional Chinese medicine extraction solution is avoided. The foam dressing is mild in nature, and has excellent effects of stopping bleeding, diminishing inflammation and promoting healing.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a hemostatic and healing-promoting foam dressing as well as a preparation method and application thereof. Background technique [0002] Traditional wound dressings include dry gauze and oiled gauze. Dry gauze is used to cover the wound, but its ability to manage exudate is limited. Adhesive wounds may cause re-injury of new epithelial tissue; oil gauze dressings contain petroleum jelly or triglycerides to avoid wound adhesions , but the ability to promote wound healing is poor. Because the liquid secreted by the wound cannot pass through the adhesive plaster layer, traditional wound dressings are likely to cause local skin soaking, making the wound and surrounding skin whiten or even rot. Modern wound dressings avoid the disadvantages of traditional wound dressings to a large extent, not only can protect the wound comprehensively, but also can promote wound healing. [0003] CN ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/40A61L15/26A61L15/42A61L15/44A61L15/46A61K36/8984A61P31/02A61K31/722
CPCA61K31/722A61K36/324A61K36/8984A61L15/26A61L15/28A61L15/40A61L15/425A61L15/44A61L15/46A61L2300/236A61L2300/30A61L2300/404A61L2300/41A61L2300/412A61L2400/04A61P31/02C08L5/08C08L67/04A61K2300/00
Inventor 车七石刘少辉李新霞
Owner GUANGZHOU RAINHOME PHARM&TECH CO LTD
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