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Optical Flow Cell and Test Head Setup

A spectrometry, photodetector technology, used in measurement devices, chemical instruments and methods, color/spectral property measurement, etc.

Active Publication Date: 2021-06-01
INSTR LAB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this configuration, the path length may be adversely affected by the compression of the elastic gasket between the first and second pool sections

Method used

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  • Optical Flow Cell and Test Head Setup
  • Optical Flow Cell and Test Head Setup
  • Optical Flow Cell and Test Head Setup

Examples

Experimental program
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Embodiment Construction

[0016] Aspects of the present disclosure include variable path length optical flow cells for use in clinical analyzers such as, but not limited to, the GEM 4000 and GEM 5000 Clinical Analyzers (Instrumentation Laboratory, Inc., Bedford, MA) Optical measurement of analytes in body fluid samples in ). In one embodiment, the disclosed flow cell is closed to provide a chamber with an optical path therethrough having a path length of about 80 microns to about 90 microns for optical determination One or more analytes of the bodily fluid sample in the chamber. When the flow cell is in the closed configuration for sample analysis, the optical path length through the upper and lower portions of the flow cell is very precise because the displacement tolerance between the upper and lower portions of the flow cell is very small. When the measurement is complete, the flow cell can be opened to flush the bodily fluid sample from the sample chamber. When the flow cell is in the open config...

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Abstract

A sample cell device (100) for spectroscopic determination of an analyte in a body fluid sample, comprising a first plate part (10) made of an optically transparent material, and a first plate part (10) made of an optically transparent material and connected to the first plate part (10) ) opposite the second plate member (20). Channels (12, 22) extending into the surface of the first plate member (10) and the opposing surface of the second plate member (20) accommodate floating seals (30). A floating seal (30) surrounds a fluid chamber (50) holding a bodily fluid sample for optical measurements. The fluid chamber (50) can be opened for flushing by separating the first plate part (10) from the second plate part (20). During the measurement, by pushing the first plate part (10) onto the second plate part (20) without compressing the floating seal (30) between the first plate part (10) and the second plate part (20), to close the fluid chamber (50) to define a reproducible optical path length.

Description

technical field [0001] Aspects of the present disclosure relate to the field of spectroscopic determination of analyte content in a sample, and more particularly to the field of presenting bodily fluid samples for spectroscopic analysis in optical flow cells. Background technique [0002] In various clinical settings, it is important to measure certain chemical properties of blood, for example, the analytes hemoglobin (eg, carboxyhemoglobin, oxyhemoglobin, methemoglobin), proteins, lipids, bilirubin. These clinical environments range from routine patient visits to physician's offices, emergency rooms, or the monitoring of inpatients. The measurement of analytes in bodily fluid samples can be accomplished in a number of ways, one of which is through spectrometry. [0003] For example, spectroscopic determination of analyte levels in a bodily fluid sample, such as a blood sample, involves presenting the bodily fluid sample to a light source and analyzing the properties of the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/03B01L3/00G01N21/05G01N21/11
CPCB01L3/508B01L2200/0689B01L2300/0822G01N21/0303G01N21/05G01N33/4915G01N2021/058G01N2021/115G01N2201/0668G01N21/27G01N2201/061G01N2201/062
Inventor 布莱恩·J·博瑟约瑟夫·克里莫
Owner INSTR LAB