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Method for extracting brain function connecting mode of migraine

A technology of brain functional connection and extraction method, applied in the field of extracting migraine brain functional connection patterns, can solve problems such as lack of biomarker signs, and achieve the effect of improving accuracy and efficiency

Inactive Publication Date: 2019-02-12
SHANGHAI MARITIME UNIVERSITY
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Problems solved by technology

And the diagnosis of migraine is based on the doctor's inquiry method, lacking clear biomarker signs

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  • Method for extracting brain function connecting mode of migraine
  • Method for extracting brain function connecting mode of migraine
  • Method for extracting brain function connecting mode of migraine

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Embodiment Construction

[0041] The present invention will be further elaborated below by describing a preferred specific embodiment in detail in conjunction with the accompanying drawings.

[0042] like figure 1 A method for extracting brain functional connection patterns of migraine is shown, and the extraction method includes the following steps:

[0043] In step 1, the resting-state fMRI data of the brains of multiple migraine patients and the resting-state fMRI data of the brains of multiple normal people are collected.

[0044] According to clinical medical diagnostic standards, the brain resting-state fMRI images of migraine patients (MP) and normal controls (NC) were collected respectively. The number of samples in each group was 35, and a total of 70 subjects were tested. During the data acquisition process, the subjects were asked to keep their brains awake and lie flat in the MRI machine. The number of time points for each subject is 160.

[0045] Step 2, preprocessing the collected rest...

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Abstract

The invention discloses a method for extracting a brain function connecting mode of migraine. The method comprises the following steps that firstly, brain resting-state functional magnetic resonance data of migraineurs and able-bodied persons are collected; then four steps of pretreatment of time horizon correction, head moving correction, standardization and smoothening are carried out on the collected data; then according to the pretreated data, each tested whole brain steady-state functional connection column vector set is acquired by using an automatic calculation mode; then clustering analysis is carried out on all tested whole brain steady-state functional connection column vector set by adopting an improved K mean value clustering algorithm; lastly, the brain function connecting mode of the migraine is extracted according to a threshold, thereby providing a basis for the subsequent further analysis. The method for extracting the brain function connecting mode of the migraine ishelpful for acquiring the brain function connecting mode of the migraine according to the dynamics.

Description

technical field [0001] The invention belongs to the technical field of medical imaging image processing, and in particular relates to a method for extracting migraine brain functional connection patterns based on dynamic functional connections. Background technique [0002] Migraine is a chronic neurological syndrome characterized by recurrent pain, often accompanied by clinical symptoms such as nausea, vomiting, light sensitivity, and noise sensitivity. The incidence of migraine is relatively high, and the symptoms seriously affect people's work efficiency and quality of life. The pathogenesis of migraine is still not completely clear. At present, there are mainly the following hypotheses: the theory of cortical spreading inhibition, the theory of trigeminal neurovascular, and the dysfunction of the central pain regulation system. And the diagnosis of migraine is based on the way of doctor's consultation, lacking clear biomarker signs. With the development of functional i...

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Application Information

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IPC IPC(8): A61B5/055A61B5/00G06K9/00G06K9/62
CPCA61B5/0033A61B5/0042A61B5/055A61B5/72G06F2218/00G06F18/23
Inventor 聂玮芳曾卫明石玉虎李颖
Owner SHANGHAI MARITIME UNIVERSITY
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