Ganoderma lucidum spore oil and novel application of pharmaceutical composition comprising ganoderma lucidum spore oil

A technology of red lucidum spores and spore oil, applied in the field of ganoderma lucidum spore oil, to achieve the effect of preventing myocardial fibrosis caused by aortic valve disease

Active Publication Date: 2019-02-15
GUANGDONG LAB ANIMALS MONITORING INST +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have shown that Ganoderma lucidum extract can treat myocardial fibrosis, but there is no application of Ganoderma lucidum extract (especially oily components) in the prevention of myocardial fibrosis, especially the application of "myocardial fibrosis caused by aortic valve disease"

Method used

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  • Ganoderma lucidum spore oil and novel application of pharmaceutical composition comprising ganoderma lucidum spore oil
  • Ganoderma lucidum spore oil and novel application of pharmaceutical composition comprising ganoderma lucidum spore oil
  • Ganoderma lucidum spore oil and novel application of pharmaceutical composition comprising ganoderma lucidum spore oil

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The extraction method of the chizhi spore oil provided by the present embodiment comprises the following steps:

[0034] (1) Take 1,000 grams of commercially available red lucidum spore powder, conduct ultrasonication, mix the ultrasonicated Ganoderma lucidum spore powder, freeze 3 times with liquid nitrogen, rewarm at 30°C, and then enzymatically enzymatically with neutral protease at 50°C, pH 7.4, for 1 hour After enzymatic hydrolysis, use potassium hydroxide to neutralize the enzyme after acid inactivation.

[0035] (2) After filtering the spore powder and drying at 50°C for 10 hours, place it in an extraction kettle and use carbon dioxide supercritical extraction. The set conditions are: ①Extraction pressure is 15Mpa, temperature is 40°C, and time is 2 hours; ②Separation pressure 6Mpa, temperature 30°C; ③CO 2 The speed is 20L / h.

[0036] Using GC-MS method to measure Chizhi spore oil, Chizhi spore oil accounts for 27% of the total mass of the extract, Chizhi spore...

Embodiment 2

[0038] The following experiments are conducted to verify the efficacy of Chizhi spore oil in preventing "myocardial fibrosis caused by aortic valve disease".

[0039] 1. Experimental animals

[0040] 48 4-week-old weaned C57 mice were kept in the SPF facility of Guangdong Experimental Animal Monitoring Institute. The temperature and humidity were constant in the facility. The animals were given 12 hours of light every day, and they automatically took food and water. Experiments were conducted in an AAALAC-accredited facility.

[0041] 2. Experimental materials

[0042] (1) Chizhi spore oil: prepared according to Example 1, and stored at 4°C for future use.

[0043] (2) Superoxide dismutase (SOD), malondialdehyde (MDA) and glutathione (GSH) detection kits: purchased from Nanjing Jiancheng Bioengineering Institute;

[0044] (3) HA and LN detection kits: purchased from Shanghai Haiyan Medical Biotechnology Co., Ltd.;

[0045] (4) Other conventional consumables: isoflurane, 4-...

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Abstract

The invention discloses ganoderma lucidum spore oil and a novel application of a pharmaceutical composition comprising the ganoderma lucidum spore oil to preparing functional foods and drugs having effects of preventing myocardial fibrosis caused by aorta valvular heart diseases. The invention discloses the ganoderma lucidum spore oil and the novel application of the pharmaceutical composition comprising the ganoderma lucidum spore oil to preventing the myocardial fibrosis caused by the aorta valvular heart diseases for the first time, a novel method is provided for preventing the myocardial fibrosis caused by the aorta valvular heart diseases, the ganoderma lucidum spore oil prepared by using the preferential method in the invention and a drug prepared from the ganoderma lucidum spore oileffectively prevent fibrosis and have the effects of preventing ventricular remodeling and heart failure.

Description

technical field [0001] The invention belongs to the technical field of ganoderma lucidum spore oil, and specifically relates to the application of ganoderma spore oil and / or a pharmaceutical composition containing the ganoderma spore oil in the preparation of functional foods and medicines capable of preventing myocardial fibrosis caused by aortic valve disease. Background technique [0002] Myocardial fibrosis is induced by diseases such as hypertension, atherosclerosis, valvular disease, hyperlipidemia, and atrial fibrillation. The disease mechanism involves myofibroblast activation, increased collagen concentration, excessive deposition of extracellular matrix, and abnormal glucose and lipid metabolism. Myocardial fibrosis ultimately results in cardiac remodeling, systolic and diastolic dysfunction, and heart failure. As a progressive disease, early prevention is of great significance, but currently there is no reliable preventive method for myocardial fibrosis. In the i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/074A61K9/107A61K9/48A61P9/00A61P9/04A23L33/115A23L33/12C11B1/02C11B1/04C11B1/10
CPCA23V2002/00A61K9/107A61K9/48A61K36/074A61K2236/19A61K2236/37A23L33/115A23L33/12A61P9/00A61P9/04C11B1/025C11B1/04C11B1/104A23V2200/326
Inventor 杨丰华黄韧谭伟江王静李想黎冰林唐林志郑双陈丽君任学聪张梦雅叶永才
Owner GUANGDONG LAB ANIMALS MONITORING INST
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