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Bromobutyl rubber stopper for freeze-drying additives and preparation method thereof

A technology of bromobutyl rubber and additives, which is applied in the field of polymer materials, can solve problems such as unsatisfactory performance, and achieve the effects of reducing quantity, increasing internal lubricity, and improving sealing performance

Active Publication Date: 2021-02-23
湖北辰诺医药包装科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, fields such as freeze-dried additives for microbial diagnosis have stricter requirements on the sealed packaging of pharmaceuticals, especially on the sealing and needle-punched chipping of halogenated butyl rubber stoppers. The existing halogenated butyl rubber stoppers have stricter requirements. Performance struggles to meet both requirements

Method used

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  • Bromobutyl rubber stopper for freeze-drying additives and preparation method thereof
  • Bromobutyl rubber stopper for freeze-drying additives and preparation method thereof

Examples

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preparation example Construction

[0013]This embodiment also provides a preparation method of the bromobutyl rubber stopper, including the following steps:

[0014]Ingredients → mixing → pre-forming → vulcanization → punching → cleaning and siliconization → packaging, the specific methods are as follows:

[0015](1) Prepare materials in parts by weight;

[0016](2) Under normal temperature and pressure, after adding BIIR2030 to the internal mixer for mixing for 1 to 2 minutes, adding calcined kaolin for mixing for 3 to 4 minutes, then adding talc, carbon black, PE wax, magnesium oxide and HY-2055 for mixing. Mix for 4~5min, discharge at 125~135℃ after mixing; put the rubber discharged from the internal mixer into the open mixer, pull the knife and cool the rubber twice on the open mixer, and add the oxidation Zinc and sulfur, mixing for 3~4min, mashing and mixing>6min, the temperature during the smelting process is 70~85℃, and the lower piece is cooled for 2~3min;

[0017](3) Put the cooled mixed rubber into the extruder, the e...

Embodiment 1

[0024]Example 1 of the present invention provides a bromobutyl rubber stopper, including the following components in parts by weight: 100 parts of BIIR2030, 60 parts of calcined kaolin, 14 parts of talc, 4 parts of carbon black, 0.4 parts of HY-2055 resin, 0.5 parts of sulfur, 1.4 parts of magnesium oxide, 4 parts of zinc oxide and 1 part of PE wax.

[0025]It is prepared by the following method:

[0026](1) Prepare materials in parts by weight;

[0027](2) Under normal temperature and pressure, after adding BIIR2030 to the internal mixer for mixing for 1 to 2 minutes, adding calcined kaolin for mixing for 3 to 4 minutes, then adding talc, carbon black, PE wax, magnesium oxide and HY-2055 for mixing. Mix for 4 to 5 minutes, and discharge the material at 130°C after mixing; put the rubber discharged from the internal mixer into the open mixer, pull the rubber on the open mixer 2 times, add zinc oxide and Sulfur, mixing for 3 to 4 minutes, mashing and mixing for 8 minutes, the temperature is 8...

Embodiment 2

[0033]Example 2 of the present invention provides a bromobutyl rubber stopper, including the following components in parts by weight: 100 parts of BIIR2030, 60 parts of calcined kaolin, 16 parts of talc, 5 parts of carbon black, 0.6 parts of HY-2055 resin, 0.7 parts of sulfur, 1.6 parts of magnesium oxide, 5 parts of zinc oxide and 0.6 parts of PE wax.

[0034]It is prepared by the following method:

[0035](1) Prepare materials in parts by weight;

[0036](2) Under normal temperature and pressure, after adding BIIR2030 to the internal mixer for mixing for 1 to 2 minutes, adding calcined kaolin for mixing for 3 to 4 minutes, then adding talc, carbon black, PE wax, magnesium oxide and HY-2055 for mixing. Mix for 4 to 5 minutes, and discharge at 125°C after mixing; put the rubber discharged from the internal mixer into the open mixer, pull the rubber on the open mixer 2 times, add zinc oxide and Sulfur, mixing for 3 to 4 minutes, mashing and mixing for 7 minutes, the temperature is 85°C during...

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Abstract

The invention discloses a brominated butyl rubber stopper for freeze-drying additives, which comprises the following components in parts by weight: 100 parts of BIIR2030, 60 parts of calcined kaolin, 14-16 parts of talcum powder, 0.6-1 part of PE wax, HY‑ 0.4-1.5 parts of 2055 resin, 4.1-6.6 parts of composite metal oxide, 0.5-1 part of sulfur and 4-5 parts of carbon black. The bromobutyl rubber stopper formula provided by the invention is unique, and various raw materials in the formula are used in combination according to a certain ratio, so that the vulcanization efficiency and crosslinking density of bromobutyl rubber can be kept within an appropriate range, and the Improves the sealability of vulcanized rubber and increases the internal lubricity of vulcanized rubber, thereby reducing the amount of needle-punched chips. The invention also provides a preparation method of the brominated butyl rubber stopper for freeze-drying additives.

Description

Technical field[0001]The invention relates to the technical field of polymer materials, in particular to a bromobutyl rubber stopper for freeze-drying additives and a preparation method thereof.Background technique[0002]Halogenated butyl rubber stoppers are currently one of the most widely used pharmaceutical packaging materials. They are a type of pharmaceutical packaging materials that directly contact drugs. Therefore, the pharmaceutical industry has higher requirements for the performance of halogenated butyl rubber stoppers. The sealing performance of the halogenated butyl rubber stopper and needle piercing debris will directly affect the performance of the packaged drugs. The Chinese pharmaceutical packaging material industry standard YBB00042005-2015 "halogenated butyl rubber stopper for injection", YBB00052005-2015 "sterile powder for injection" Halogenated butyl rubber stoppers in standards such as "Halogenated Butyl Rubber Stoppers" and other standards require that the sel...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L23/28C08L23/06C08K13/06C08K3/34C08K3/22C08K3/04
CPCC08K2003/222C08K2003/2296C08L23/283C08L2205/03C08L23/06C08K13/06C08K3/346C08K3/34C08K3/22C08K3/04
Inventor 郑明爱
Owner 湖北辰诺医药包装科技有限公司
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