Two-dimension material heterojunction sensor

A two-dimensional material and heterojunction technology, applied in the field of MEMS, achieves the effects of excellent selectivity, low power consumption, and less sample consumption

Pending Publication Date: 2019-03-01
TSINGHUA UNIV
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Problems solved by technology

Micro-nano biosensors based on two-dimensional material heterojunctions have not been reported yet

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Embodiment Construction

[0024] The technical solutions of the present invention will be further described below in conjunction with the accompanying drawings and embodiments.

[0025] The present invention is described below based on examples, but the present invention is not limited to these examples.

[0026] refer to figure 1 , figure 2 , a two-dimensional material heterojunction sensor, the device structure from top to bottom is selection layer 1-1, tungsten diselenide layer 1-2, molybdenum disulfide layer 1-3, substrate 1-4; diselenide The tungsten layer 1-2 overlaps with the molybdenum disulfide layer 1-3 to form a heterojunction 1-6; the surface of the heterojunction 1-6 is modified with an antibody corresponding to the tumor marker to be tested, and the metal electrodes 1-5 are respectively connected with The molybdenum disulfide layer 1-3 is connected to the tungsten diselenide layer 1-2.

[0027] The tungsten diselenide layer 1-2 is a two-dimensional material, that is, there is only a s...

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Abstract

The invention provides a two-dimension material heterojunction sensor, and belongs to the technical field of MEMS. The sensor structurally comprises a selective layer, a tungsten diselenide layer, a molybdenum disulfide layer and a substrate from top to bottom in sequence, wherein the tungsten diselenide layer and the molybdenum disulfide layer are overlapped to form a heterojunction; the surfaceof the heterojunction is modified with an anti-body corresponding to a to-be-tested tumor marker, the sites, which are not covered with the anti-body, on the surface of the heterojunction are filled with bovine serum albumin, and the anti-body and the bovine serum albumin form the selective layer. Metal electrodes are connected with the molybdenum disulfide layer and the tungsten diselenide layerrespectively, the heterojunction formed by tungsten diselenide and molybdenum disulfide is used as the core sensitive part of the sensor, the concentration of the marker is detected by using the characteristic that the heterojunction is sensitive to protein molecules, and the sensor has an important significance for early diagnosis of cancer.

Description

technical field [0001] The invention relates to the technical field of MEMS, in particular to a two-dimensional material heterojunction sensor, which adopts the heterojunction formed by molybdenum disulfide and tungsten diselenide as the core part of the sensor, and uses its biochemical sensitive characteristics to detect the concentration of markers. Background technique [0002] Nearly 3 million people die from cancer every year in my country, and the trend is increasing year by year. Cancer has become the disease that causes the largest number of deaths in our country. An important reason for the high mortality rate of cancer is the lack of early diagnosis methods. Most patients are difficult to be detected in the early stage, which delays the best treatment time, greatly increases the difficulty of treatment, and makes many patients who could have been cured lose hope of survival. . Therefore, the early diagnosis of cancer is a major issue related to the national econo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/327
CPCG01N27/3278
Inventor 李鹏
Owner TSINGHUA UNIV
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