Novel application of Chinese pulsatilla root

A technology of pulsatilla and form, applied in the field of medicine, can solve problems that have not yet been reported on the research of pulsatilla

Inactive Publication Date: 2019-03-05
BEIJING UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its pharmacological research mainly focuses on anti-tumor, enhancing immunity, anti-oxidation, anti-inflammation, anti-trichomonas, liver protection, etc., and there is no research report on the treatment of heart failure.

Method used

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  • Novel application of Chinese pulsatilla root
  • Novel application of Chinese pulsatilla root

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] The preparation of embodiment 1 pulsatilla extract

[0017] Take Pulsatilla pulsatillae medicinal material, extract twice with 10 times the amount of water, 2.0 hours each time, filter the extract, combine the filtrates, concentrate under reduced pressure to a thick paste with a relative density of 1.48g / mL, and set aside.

Embodiment 2

[0018] The preparation of embodiment 2 pulsatilla extract

[0019] Pulsatilla pulsatillae medicinal material was ultrasonically extracted twice with 70% ethanol for 40 minutes each time, the extract was filtered, the filtrates were combined, ethanol was recovered, dried under reduced pressure, and set aside.

Embodiment 3

[0020] The preparation of embodiment 3 pulsatilla extract

[0021] Pulsatilla pulsatillae medicinal material was ultrasonically extracted twice with 70% ethanol for 40 minutes each time, the extract was filtered, concentrated under reduced pressure until it had no alcohol smell, and then extracted sequentially with petroleum ether, chloroform, ethyl acetate and n-butanol respectively to obtain Petroleum ether extract, chloroform extract, ethyl acetate extract, n-butanol extract.

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Abstract

The invention relates to an application of Chinese pulsatilla root in the preparation of drugs for treating heart failure; and the research finds that Chinese pulsatilla root can inhibit excess thickness increasing of ventricular walls, delay cardiac remodeling, improve the functions of heart, obviously reduce the expression of ANP and BNP, and relieve myocardial fibrosis.

Description

technical field [0001] The invention relates to a new application of pulsatilla, in particular to a new application of pulsatilla in treating heart failure, and belongs to the field of medicine. Background technique [0002] Pulsatilla is the dry root of the perennial herb Pulsatilla Chinensis (Bge.) Regel, which has the effects of clearing heat and detoxification, cooling blood and stopping dysentery, and is clinically used for diseases such as amoebic dysentery, bacillary dysentery and vaginal trichomonas. Its chemical composition mainly includes triterpene saponins, triterpene acids, lignans, pulsatilla, pulsatilla, pulsatilla, protopulsatin, carotin, and glycoprotein. Its pharmacological research mainly focuses on anti-tumor, enhancing immunity, anti-oxidation, anti-inflammation, anti-trichomonas, liver protection, etc. There is no research report on the treatment of heart failure by Pulsatilla pulsatillae. Contents of the invention [0003] One of the objectives of t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61P9/04
CPCA61K36/71
Inventor 王伟刘斌郭淑贞柴欣楼任莹璐张惠敏
Owner BEIJING UNIV OF CHINESE MEDICINE
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